Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime

  • K. Sundaresan Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India
  • M. Thangavel Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India
  • K. Tharini Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

Abstract

The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine.


Keywords: N-Benzyl piperidin 4-one oxime, meristamatic cells, mitotic index.

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Author Biographies

K. Sundaresan, Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

M. Thangavel, Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

K. Tharini, Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

Dept of Chemistry, Govt Arts College, Trichy-22, Tamil Nadu, India

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How to Cite
Sundaresan, K., Thangavel, M., & Tharini, K. (2019). Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime. Journal of Drug Delivery and Therapeutics, 9(1), 233-236. https://doi.org/10.22270/jddt.v9i1.2228