Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime
The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine.
Keywords: N-Benzyl piperidin 4-one oxime, meristamatic cells, mitotic index.
2. Pandiarajan K.; Sabapathy Mohan R.T.; Krishnakumar, R. Indian J. Chem. 1987, 26B, 624.
3. Pandiarajan K.; Sekar R.; Anantharaman, R.; Ramalingam, V. Indian J. Chem.1991, 30B, 490.
4. Fiskesjo G., The Allium test-an alternative in environmental studies, the relative toxicity of metal. Mutation Res. 1988, 197:243-260.
5. Shweta SS, Tapadiya GG, Lamale JJ, Khadabadi SS. Phytochemical screening and antioxidant, antimitotic and antiproliferative activities of Trichodesma indicum shoot. Ancient Sci Life 2014:34:113
6. Badria F.A.R., Houssein W.E., Zaghloul M.G., Halim A.F., Antimitotic activity of gossypol and gossypolone. Pharmaceutical Biol., 2001, 39:120 – 126
7. Fisun K and Rasgele P. G. “Genotoxic effects of Raxil on root tips and anthers of Allium cepa L.” Caryologia. 2009, 62:1, 1-9.
8. Helsel Z.R. Pesticide use in world agriculture. In: Stout, B. A, Energy in World agriculture, Elsevier, New York. 1987. 2, 179-195.
9. Abhang R.Y, Jogiekar PP, Kulkarni P H. Preliminary on the effect of T.cordifolia.on mitosis, Ancient sci 1991; 1:27.
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