Therapeutical and medicinal properties of Neem (Azadirachta indica) in context of Unani system of medicine: a review study

  • Haider Ali Quraishi P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.
  • Naquibul Islam Professor and HOD Moalijat (Unani Medicine), Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.
  • Arsheed Iqbal P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.
  • Shabir Ahmad Bhat P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar
  • Jameel Ahmed P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.
  • Syed Sabahat Ashraf P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.
  • Qamar Alam Khan Clinical Registrar, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi

Abstract

Neem is very important medicinal plant which is used to treat different diseases in Unani System of Medicine as well as traditional system of medicine (Ayurveda, Homeopathic Chines and European “Materia Medica”). The use of traditional medicine and medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. In the last century, approximately 130 pharmaceutical products have been discovered based on the information obtained from the traditional scientist and physician. The importance of the neem tree has been recognized by the US National Academy of Sciences, which publish a report in 1992 entiteled ‘Neem- a tree for solving global problems’. The scientific name of neem, Azadirachta indica, is derived from the Persian, Azad means “Free” dirakht means “tree” I-Hindi means “of Indian Origin” .Hence it literally means “the free tree of India”. The Chemical principles from natural sources have become much simpler and have contributed significantly to the development of new drugs from medicinal plants and because of these facts the domain market for plant derived chemicals, pharmaceuticals, fragrances, flavor’s, and color ingredients, alone exceeds several billion dollars per year. The present review highlights a Unani medicine literature as well as scientific on taxonomical, botanical, and pharmacological discussion on Neem.


Keywords: Neem, Azadirachta indica, Unani Medicine, Nim.

Downloads

Download data is not yet available.

Author Biographies

Haider Ali Quraishi, P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

Naquibul Islam, Professor and HOD Moalijat (Unani Medicine), Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

Professor and HOD Moalijat (Unani Medicine), Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

Arsheed Iqbal, P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

Shabir Ahmad Bhat, P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar

P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar

Jameel Ahmed, P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

Syed Sabahat Ashraf, P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

P.G. (M.D) Scholar Unani Medicine, Regional Regional Research Institute of Unani Medicine, University of Kashmir, Srinagar.

Qamar Alam Khan, Clinical Registrar, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi

Clinical Registrar, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi

References

1. Ghani NH, “Khazainul Advia”. Idara Kitabul Shifa; New Delhi: YNM; 988-996.
2. Sheerazi A, Tohgatul Monineen wa Makhzam-ul-Advia (Persian), Idara Kitabul Shifa; New Delhi: 1917; 780-781.
3. Sharif M, Riyazul Advia, Matba Mustafa Musrafa Mohd. Hussain Khan, Idara Kitabul Shifa,New Delhi: YNM; 413- 414.
4. Kabeeruddin M. “Makhzen ul Mufredat”. Ejaz Publishing House; New Delhi: YNM; 219.
5. Hakeem MA, Bustanul Mufradat, (Reprinted recently) Idara-e-Tarraqqi Urdu Publication, Lucknow: 1311; 341.
6. Kareem, Noor, Mukhzanul Advia, Ejaz Publishing House; New Delhi: 1888; 1: 186.
7. Ghulam, HS, Ganjeena-e Tib Mumtazia, Matba Mumtazia, Agra: 1888; 365-366.
8. Ali, MS, Aneesul Atibba, Shame Jahan Raunaq Fiza Gulshan, Lahore: 1875; 251-252.
9. Anonymous, Wealth of India, C.S.I.R., New Delhi: 1985; I: 506.
10. Manjunath BL, The wealth of India, CSIR, New Delhi: 1948; I:140.
11. Chopra RN., Chopra, I. C, Handa, K. L. and Kapur, L. D. (eds), Indigenous Drugs of India, U.N. Dhur and Sons, Kolkata: 1958; 51-595.
12. Haider AK, Majmaul Behrin, Tibbi publishing House, Nawal Kishore, Lucknow: 1905;174.
13. Dymock W., Warden, C.J.H. and Hooper, D, Pharmacographia Indica, The Institute of Health and Tibbi Research (Republished under the auspices of Hamdard National Foundation), Pakistan: 1890; 1: 322.
14. Nadkarni AK, “Indian Materia Medica with Ayurvedic, Unani Tibbi,Siddha, Allopathic, Homeopathic, Naturopathic and Home remedies”.Vol.1st .Bombay: Popular Parkashan Private Ltd. 2009; 776.
15. Rojanapo W, Suwanno S, Somaree R, Glinsukon T, Thebtaranonth Y., Screening of Antioxidants from some Thia vegetables and herbs. J Sci Thailand 1985; 11: 177– 188.
16. Pillai NR. and Santhakumari G, Planta Medica, 1984; 50,143,146.
17. Okpanyi SN. and Ezeukwu, G.C, Plata Medica, 1981; 34.
18. Kurokawa Y., Tekeda, T., Ogihara, Y., Shimazu, M., and Takai, M, Chem Pharama. Bull., 1988; 36, 2654.
19. Schmutterer H, The Neem Tree: Source of Unique Natural Products for Integrated Pest Management, Medicine, Industry and Other Purposes, VCH, Weinheim, Germany: 1995; 1- 696.
20. Shimazu M., Sudo, T. and Nomura, T., Parentschrift , J.P. Chem., 1985; 103: 650,404.
21. Vander JM., Vander Sluis, W.G., De Silva, K. T. D. and Labadei, R.P, J. Ethnopharmocology, 1991; 35, 41.
22. Singh D, Unani Dravya Gun Vigyan, Nirnay Sagar Press, Mumbai: 1949; 304.
23. Kirtikar, K. R. and Basu, B. D., in Medicinal Plants (eds Blatter, E., Cains, J. F., Mhaskar, K. S.), Vivek Vihar, New Delhi: 1975; 536.
24. Perry LM. and Metzgher, J, Medicinal Plants of East and South East Asia, M.I.T. Press, London. 1895; 260-261.
25. Watt G, A Dictuinary of the Economic Products of India vol 5, Cosmopublication, Delhi: 1972; 241.
26. Iffat A, Siddiqui BS, Faizi S, Siddiqui S., Structurally novel diterpenoid constituent from the stem bark of Azadirachta indica (meliaceae). J Chem Soc Perkin Tran. 1989; 2: 343-345.
27. Jones I, Ley SV, Denholm AA, Lovell H, Wood A, Sinden RE., Sexual development of malaria parasites is inhibited in-vitro by the neem extract azadirachtin, and its semisynthetic analogs. FEMS Microbiol Lett. 1994; 120: 267–273.
28. Lavie D., Levy, E.C. and Jain, M.K, J Tetrahedron, 1971; 27: 3927.
29. Kraus, W., in The Neem Tree: Source of Unique Natural Products for Integrated Pest Management, Medicine, Industry and Purposes (ed. Schmutterer, H.), 1995; 35-88.
30. Ara 1., Siddiqui, B. S., Faizi, A. and Siddiqui, S, J Fitoterapia,1992; 63: 118.
31. Siddiqui, S.Siddiqui, B. S., Mahmood, T. and Faizi, S, J. Nat. Prod., Journal of Phytochemistry 1991; 30: 1615.
32. Narayana CR. and Lyer, K.N, Indian Journal of Chemistry, 1967; 5: 460.
33. Rochanakij S, Thebtaranonth Y, Yenjal CH, Yuthavong Y., Nimbolide, a constituent of Azadirachta indica inhibits Plasmodium falciparum in culture. Southeast Asian J Trop Med Public Health, 1985 : 16: 66–72
34. Ara 1, Siddiqui. B.S., Faizi, S., and Siddiqui, S, J. Nat Prod., 1990; 53: 816.
35. Balandirin MF., Lee, S. M. and Klocke, J. A, J. Agric. Food. Chem., 1988; 36: 1048.
36. Sharma VN, Saksena KP, Sodium nimbidinate in vitro studty of its spermicidal action, Indian J. Med Res, 1959; 13: 1038.
37. Siddiqui S., Siddiqui, B.S. and Ghiasuddin and Faizi, S, J. Nat. Prod., 1991; 54: 408.
38. Gaikwad, B.R., Mayelvagnan, T., Vyas, B.A. and Bhat, S.V, J Phytochemistry, 1990; 29:3963.
39. Ara I, Z. siddiqui, B.S., and Siddiqui, S, J Phytochemistry, 1990; 29:911.
40. Ara I, Siddiqui BS, Faizi S, Siddiqui S, Structurally novel diterpenoid constituents from the stem bark of Azadirachta indica(meliaceae). J Chem Soc Perkin Trans, 1989; 2: 343–345.
41. Ara I., Siddiqui, B.S., Faizi, A. and Siddiqui, S, J Fitoterapia, 1989; 60: 519.
42. Lavie D., Jain, M.K. and Shpan Gavrieliyh, S.R., J Chem. Commun, 1967; 910.
43. Banerji R., Misra, G. and Nigam, S.K, J Phytochemistry, 1987; 26:2644.
44. Ara I, Siddiqui, B.S., Faizi, S., and Siddiqui, S, J Phytochemistry, 1989; 28:1177.
45. Ara I, Siddiqui, B.S., Faizi, S. and Siddiqui,. S, J. Nat. Prod.,1988; 51:1054.
46. Rojatkar SR., Bhat, V.S., Kulkarni, M.M., Joshi, V.S. and Nagasampagi, B.A, Phytochemistry, 1989; 28,203.
47. Majumdar PL., Maiti, D. C., Kraus, W., and Bokel, M, J Phytochemistry, 1987; 26: 3021.
48. Henderson R., Mc Crindle, R., Overton, K. H., Mebra, A, Tetrahedron Lett., 1964; 3969.
49. Siddiqui S., Siddiqui, S.B., Faizi, S. and Mahmood, T,J Hetercycles, 1986; 24: 3163.
50. Mukherjee S, Garg S, Talwar GP. Early post implantation contraceptive effects of a purified fraction of neem (Azadirachta indica) seeds, given orally in rats: possible mechanisms involved. J Ethnopharmacol. 1999; 67(3):287-96.
51. Lakshmi SU. and Pattabiraman, T. N, Ind. J. of Biochem., 1967; 4: 181.
52. Dixit VP., Sinha, R. and Tank, R, J. Ethnopharmocology, 1986; 17-95.
53. Hawary EI, Z.M. and Kholief, T.S, Archives J Pharmacol. Res., 1990; 13(1):108-3963.
54. Chattopadhya RN, Mita, S. K. and Chattopadhya, R.R, Fitoterapia., 64(4), J Pharmacology,1993; 25(2): 99-100.
55. Mukherjee S, Lohiya NK, Pal R, Sharma MG, Talwar GP, Purified neem (Azadirachta indica) seed extracts (Praneem) abrogate pregnancy in primates. Contraception, 1996; 53(6): 375-8.
56. Tandon SK, Chandra, S., Gupta, S., Trioathi, H. C. and Lal, J.,J Fitoterapia, 1990; 61, 75.
57. Khanna, N., Goswami, M., Sen, P. and Ray, A, Indian J. Exp. Biol., 1995; Nov., 33(11): 848-850.
58. Vanugopal PV and Venugopal, T.V, Indian J. of Pharmacology, 1993; 26 (2): 141-143.
59. Lal R, Ghandhi, M., Shankaranaranyanan, A., Mathur, V.S. Sharma, P.L., J Fitoterapia, 1988; 23, 53.
60. Prakash AO, Tewari RK, Mathur R, Nonhormonal post-coital contraceptive action of neem oil in rats. J Ethnopharmacol, 1988; 23(1):53-9.
61. Prakash AO, Tewari RK, Mathur R, Nonhormonal post-coital contraceptive action of neem oil in rats. J Ethnopharmacol, 1991; 28, 163.
62. Sinha KC, Riar SS, Tiwary RS, Dhawan AK, Bardhan J, Thomas P, Kain AK, Jain RK, Neem oil as a vaginal contraceptive. Indian J Med Res, 1984; 79:131-6.
63. Tewari RK., Mathur, R. and Prakash, A. O, International Research Communication System of Medical Science, 1986; 14: 1005.
64. Brar SS., Devakumar, C., Sawheny, R.C., Ilavazhagan, G., Bardhan, J., Kain, A.K.,Thomas, P., Singh, R., Singh. B. and Rajinder parshad., J Contraception, 1990; 42-470.
65. Brar SS, Devakumar, C., Sawhney, R.C., llavazhagan, G., Brdhan, G., Bardhan, J., Kain, A.K., Thomas, P., Singh, R., Singh.B. and Rajinder Pajinder Parshad., J Contraception, 1991; 44-319.
66. Upadhyay SN, Kaushic, C. and Talwar, G.P, Proc. R. Soc. London and Biol. Sci. England, 1990; 175-9.
67. Upadhyay SN, Dhawan S, Talwar GP, Antifertility effects of neem (Azadirachta indica) oil in male rats by single intra-vas administration: an alternate approach to vasectomy. J Androl, 1993; 14(4):275-81.
68. Bardhan J, Riar SS, Sawhney RC, Kain AK, Thomas P, Ilavazhagan G. Neem oil--a fertility controlling agent in rhesus monkey. Indian J Physiol Pharmacol. 1991; 35(4):278-80.
69. Garg S, Taluja V, Upadhyay SN, Talwar GP, Studies on the contraceptive efficacy of Praneem poly herbal cream. Contraception, 1993; 48(6): 591-6.
70. Koley KM. Lal J. and Tandan, S.K, J Fitoterapia, 1994; 6-66, 524-528.
71. Chattopadhyay, R.R., Chattopadhyay, R.N. and Maitra, S.K, Indian Journal of Pharmacology, 1992; 25 (2): 99-100.
72. Garg GP., Nigam, S.K. and Ogle, C.W, Planta Medica, 1993; 59 (3): 215-217.
73. Koley KM. and Lal, J, Indian J. Physiol. Pharmacol., 1994; Jul., 38(3):323-325.
74. Vandernat, J.M., kierz, J.P.A.M., Vann Dijkm H., Desilva, K.T.D. and Labadie, R.P, J. Ethnopharmocology, 1987;19: 125.
75. Prakash, AO., Mishra, A., Mehta, H. and Mathur, R, Nonhormonal post-coital contraceptive action of neem oil in rats. J Ethnopharmacol,1991; 62, 99.
76. Singh, P. P., Jinnarkr A.K. Reddi, G.S., and Singh, K.V, Fitoterapia, 1987; 58: 235.
77. Gandhi, M., Lal, R., Sankaranarayanan, A., Banerje, C.K. and Sharma, P.L, J. Ethnopharmacology, 1989; 23-39.
Statistics
876 Views | 744 Downloads
How to Cite
1.
Quraishi HA, Islam N, Iqbal A, Bhat SA, Ahmed J, Ashraf SS, Khan QA. Therapeutical and medicinal properties of Neem (Azadirachta indica) in context of Unani system of medicine: a review study. JDDT [Internet]. 15Dec.2018 [cited 27Jan.2023];8(6-s):394-9. Available from: http://jddtonline.info/index.php/jddt/article/view/2141