Mini Review: Modulating cytotoxicity effects in Cancer Drug Delivery

  • Hao Wu 1School of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China 2 Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China 3 Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210023, P. R. China 4 State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

Abstract

A review of cytotoxicity associated with cancer treatments as presented in literature was discussed. In all the studies, the research is aware of the cytotoxic effects of the cancer drug and the delivery form such as nanotechnology-based delivery. The scope of the review was limited to showing 1) the need for modulating cytotoxicity and 2) how cytotoxicity has been controlled in actual studies on treatment plans in vivo and in vitro.


Keywords: Cytotoxicity, in vivo, in vitro, nanotechnology, nanoparticles, apoptosis

Downloads

Download data is not yet available.

Author Biography

Hao Wu, 1School of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China 2 Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China 3 Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210023, P. R. China 4 State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

1School of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

2  Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

3 Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210023, P. R. China

4 State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

References

1. Kang, C., Qin, J., Osei, W. & Hu, K. Age-dependent Mitochondrial Targeting Of Protein Kinase C Epsilon In Cardioprotection. The FASEB Journal (2017).
2. Han, R., Sun, Y., Kang, C., Sun, H. & Wei, W. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. Journal of Drug Targeting 2017; 25:140-148.
3. Sun, Y., et al. Co-delivery of dual-drugs with nanoparticle to overcome multidrug resistance. European Journal of BioMedical Research 2016; 2:12-18.
4. Liu, F., Sun, Y. & Kang, C. Controlling Amphiphilic Functional Block Copolymers’ Self-Assembly: From Structure to Size. (2016).
5. Song, L., et al. Crocetin inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells. Cellular Physiology and Biochemistry 2016; 40:443-452.
6. Sun, Y., Kang, C., Liu, F. & Song, L. Delivery of antipsychotics with nanoparticles. Drug Development Research 2016; 77:393-399.
7. Kang, C., et al. Delivery of nanoparticles for treatment of brain tumor. Current Drug Metabolism 2016; 17:745-754.
8. Xue, X., et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking. PeerJ 2016; 4:e2757.
9. Shuhong, X., et al. Dynamic expression of AQP4 in early stageof ischemia/reperfusion rats and cerebral edema. Chinese Pharmacological Bulletin 2016; 32:1433-1441.
10. Peng, J., et al. Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability. Cellular Physiology and Biochemistry 2018; 47:784-799.
11. Yang, Z., et al. Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation. Journal of Controlled Release 2016; 243:160-171.
12. Kang, C., Hernandez, V.A. & Hu, K. Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 2017; 1864:1537-1544.
13. Waller, A.P., et al. GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 2013; 1832:121-127.
14. Li, Q., et al. Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors. PeerJ 2018; 6:e4206.
15. Chen, Y., et al. Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors. PeerJ 2016; 4:e2140.
16. Kang, C. & Hu, K. Impact of hypoxia in the expression and regulation of the TASK-1 potassium channel in cardiac myocytes. The FASEB Journal 2016; 30:lb598-lb598.
17. Kang, C. Ion channels, protein kinase C and caveolae in cardioprotection, (The Ohio State University, 2015).
18. Yung, B.C., et al. Lipid nanoparticles composed of quaternary amine–tertiary amine cationic lipid combination (QTsome) for therapeutic delivery of AntimiR-21 for lung cancer. Molecular pharmaceutics 2016; 13:653-662.
19. Cheng, X., et al. Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer. Pharmaceutical research 2017; 34:310-320.
20. Kang, C. & Hu, K. Modulation of the two-pore domain potassium channel TASK-1 by caveolin-3. The FASEB Journal 2015; 29:845.814.
21. Kang, C., Sun, Y., Wang, M. & Cheng, X. Nanosized camptothecin conjugates for single and combined drug delivery. European Journal of BioMedical Research 2016; 2:8-14.
22. Qiao, H., et al. Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease. Drug Delivery 2017; 24:233-242.
23. Liu, F., Sun, Y., Kang, C. & Zhu, H. Pegylated Drug Delivery Systems: From Design to Biomedical Applications. Nano LIFE 2016; 6:1642002.
24. Sun, Y., Kang, C., Yao, Z., Liu, F. & Zhou, Y. Peptide-Based Ligand for Active Delivery of Liposomal Doxorubicin. Nano Life 2016; 6:1642004.
25. Qiao, H., et al. Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer. Journal of drug targeting 2018; 26:75-85.
26. Kang, C., Qin, J., Osei, W. & Hu, K. Regulation of protein kinase C-epsilon and its age-dependence. Biochemical and Biophysical Research Communications 2017; 482:1201-1206.
27. Sun, Y., et al. RGD Peptide‐Based Target Drug Delivery of Doxorubicin Nanomedicine. Drug development research 2017; 78:283-291.
28. Kang, C. & Hu, K. Role of caveolin-3 in adenosine-induced increase in mitochondrial PKCε. The FASEB Journal 2013; 27:1191.1197-1191.1197.
29. Cheng, X. & Lee, R.J. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev 2016; 99:129-137.
30. Sun, Y. & Kang, C. Self-Assembly of Peptides into Hydrogel. Journal of Organic & Inorganic Chemistry 2016; 2:5.
31. Yao, Z., Sun, Y. & Kang, C. Structure and self-assembly of multicolored Naphthalene Diimides Semiconductor. Nano LIFE 2016; 6:1642007.
32. Cheng, X., et al. T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas. Molecular pharmaceutics 2018; 15:4722-4732.
33. Zhong, X., Sun, Y., Kang, C. & Wan, G. The theory of dielectrophoresis and its applications on medical and materials research. European Journal of BioMedical Research 2017; 2:7-11.
Statistics
23 Views | 24 Downloads
How to Cite
Wu, H. (2018). Mini Review: Modulating cytotoxicity effects in Cancer Drug Delivery. Journal of Drug Delivery and Therapeutics, 8(6), 272-274. https://doi.org/10.22270/jddt.v8i6.2054