Mini-review: Combination and Co-delivery in Cancer Treatment Efficacy

  • Shuosheng Zhang College of traditional Chinese medicine, Shanxi University of Traditional Chinese Medicine, No. 121 of University Street, 030619, Jinzhong, Shanxi, China


The mini-review focuses on the cancer therapy treatment efficacy as enhanced through combination and co-delivery methods. The focus is on nano-delivery methods and how in spite of the challenges in developing co-delivery, their potential is analyzed across different clinical fields.

Keywords: Cancer therapy, combination, co-delivery, nano-delivery, nano micelles, nanoscale, nanoparticles


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Author Biography

Shuosheng Zhang, College of traditional Chinese medicine, Shanxi University of Traditional Chinese Medicine, No. 121 of University Street, 030619, Jinzhong, Shanxi, China

College of traditional Chinese medicine, Shanxi University of Traditional Chinese Medicine, No. 121 of University Street, 030619, Jinzhong, Shanxi, China


1. Kang C., Qin J., Osei W. & Hu K. Age-dependent Mitochondrial Targeting Of Protein Kinase C Epsilon In Cardioprotection. The FASEB Journal (2017).
2. Han R., Sun Y., Kang C., Sun H. & Wei W. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. Journal of Drug Targeting 2017; 25:140-148.
3. Duan Y., et al. Bioactivity evaluation-based ultra high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry and novel distinction of multi-subchemome compatibility recognition strategy with Astragali Radix-Fructus Corni herb-pair as a case study. J Pharm Biomed Anal 2016; 129:514-534.
4. Sun Y., et al. Co-delivery of dual-drugs with nanoparticle to overcome multidrug resistance. European Journal of BioMedical Research 2016; 2:12-18.
5. Ai R., et al. Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Nat Commun 2018; 9:1921.
6. Fan S., et al. Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis. Bioinformatics 2016; 32:1773-1778.
7. Liu F., Sun Y. & Kang C. Controlling Amphiphilic Functional Block Copolymers’ Self-Assembly: From Structure to Size. (2016).
8. Song L., et al. Crocetin inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells. Cellular Physiology and Biochemistry 2016; 40:443-452.
9. Sun Y., Kang C., Liu F. & Song L. Delivery of antipsychotics with nanoparticles. Drug Development Research 77, 393-399 (2016).
10. Kang C., et al. Delivery of nanoparticles for treatment of brain tumor. Current Drug Metabolism 2016; 17:745-754.
11. Xue X., et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking. PeerJ 2016; 4:e2757.
12. Hersch S.J., et al. Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli. MBio 2013; 4:e00180-00113.
13. Shuhong X., et al. Dynamic expression of AQP4 in early stageof ischemia/reperfusion rats and cerebral edema. Chinese Pharmacological Bulletin 2016; 32:1433-1441.
14. Peng J., et al. Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability. Cellular Physiology and Biochemistry 2018; 47:784-799.
15. Yang, Z., et al. Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation. Journal of Controlled Release 2016; 243:160-171.
16. Kang C., Hernandez V.A. & Hu K. Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 2017; 1864:1537-1544.
17. Waller A.P., et al. GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 2013; 1832:121-127.
18. Li Q., et al. Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors. PeerJ 2018; 6:e4206.
19. Chen, Y., et al. Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors. PeerJ 2016; 4:e2140.
20. Kang C. & Hu K. Impact of hypoxia in the expression and regulation of the TASK-1 potassium channel in cardiac myocytes. The FASEB Journal 2016; 30:lb598-lb598.
21. Kang C. Ion channels, protein kinase C and caveolae in cardioprotection, (The Ohio State University, 2015).
22. Yung B.C., et al. Lipid nanoparticles composed of quaternary amine–tertiary amine cationic lipid combination (QTsome) for therapeutic delivery of AntimiR-21 for lung cancer. Molecular pharmaceutics 2016; 13:653-662.
23. Cheng X., et al. Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer. Pharmaceutical research 2017; 34:310-320.
24. Fan S. & Chi W. Methods for genome-wide DNA methylation analysis in human cancer. Brief Funct Genomics 2016; 15:432-442.
25. Kang C. & Hu K. Modulation of the two-pore domain potassium channel TASK-1 by caveolin-3. The FASEB Journal 2015; 29:845.814.
26. Qiao H., et al. Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease. Drug Delivery 2017; 24:233-242.
27. Qiao H., et al. Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer. Journal of drug targeting 2018; 26:75-85.
28. Kang C., Sun Y., Wang,M. & Cheng X. Nanosized camptothecin conjugates for single and combined drug delivery. European Journal of BioMedical Research 2016; 2:8-14.
29. Liu F., Sun Y., Kang C. & Zhu H. Pegylated Drug Delivery Systems: From Design to Biomedical Applications. Nano LIFE 2016; 6:1642002.
30. Sun Y., Kang C., Yao Z., Liu F. & Zhou Y. Peptide-Based Ligand for Active Delivery of Liposomal Doxorubicin. Nano Life 2016; 6:1642004.
31. Fan S., Huang K., Ai R., Wang M. & Wang W. Predicting CpG methylation levels by integrating Infinium HumanMethylation450 BeadChip array data. Genomics 2016; 107:132-137.
32. Kang C., Qin J., Osei W. & Hu K. Regulation of protein kinase C-epsilon and its age-dependence. Biochemical and Biophysical Research Communications 2017; 482:1201-1206.
33. Sun Y., et al. RGD Peptide‐Based Target Drug Delivery of Doxorubicin Nanomedicine. Drug development research 2017; 78:283-291.
34. Kang C. & Hu K. Role of caveolin-3 in adenosine-induced increase in mitochondrial PKCε. The FASEB Journal 2013; 27:1191.1197-1191.1197.
35. Cheng X. & Lee R.J. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev 2016; 99:129-137.
36. Sun Y. & Kang C. Self-Assembly of Peptides into Hydrogel. Journal of Organic & Inorganic Chemistry 2016; 2:5.
37. Yao Z., Sun Y. & Kang C. Structure and self-assembly of multicolored Naphthalene Diimides Semiconductor. Nano LIFE 2016; 6:1642007.
38. Cheng X., et al. T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas. Molecular pharmaceutics 2018; 15:4722-4732.
39. Zhong X., Sun Y., Kang C. & Wan G. The theory of dielectrophoresis and its applications on medical and materials research. European Journal of BioMedical Research 2017; 2:7-11.
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How to Cite
Zhang S. Mini-review: Combination and Co-delivery in Cancer Treatment Efficacy. JDDT [Internet]. 15Nov.2018 [cited 24Feb.2020];8(6):261-4. Available from: