CONTROLLED DRUG RELEASE OF GRAFTED PECTIN
Modification of Pectin as natural polymer was accepted as new bio adhesive polymer, which was grafted with Maleic anhydride as vinylic monomore and insertion by using ceric ion it, was substituted with amino drugs produced amide polymer which do not lose their biological properties. This design carries controlled delivery which could release the entrapped drug over an extended period of time due to its slow digesting nature. The prepared adhesive drug polymer was characterized by FTIR, 1H-NMR spectroscopes, thermo gravimetric analysis TGA and DSC were careful. Physical properties of prepared polymer was quiet, Biological activity was studied for adhesive drug polymer, this new adhesive drug biological polymers were applied on different infected mice and wounds, It gave outstanding results and compliance mice infected with a full recovery by a short period of time. The prepared drug copolymer was analyzed in different pH values at 37 0C in vitro study and controlled drug release was messured through three days. The rate of hydrolysis in basic medium was found higher than acidic medium. It was concluded that modified drug release with extended drug action via slow release and in vivo performance was renowned to be talented.
Keywords: Pectin, controlled delivery, adhesive drug polymers, Graft Copolymer
2- Susheel K., Sabaa M.W., “Polysaccharide Based Graft Copolymers”, 1Bahra University, India, 2Faculty of Science Cairo University, Egypt, 2013.
3- Vijay K. Thakur and Manju K. Thakur, “Handbook of Polymers for Pharmaceutical Technologies”, Volume 2, Washington State University, USA, 2015.
4- Rohini, Neeraj A., Anupam J., and Alok M., “Polymeric Prodrugs: Recent Achievements and General Strategies”, J Antivir Antiretrovir 2013; S15:1-12.
5- Zhang Y., Chan H.F., and Leong K.W., “Advanced materials and processing for drug delivery: the past and the future, Advanced drug”, delivery reviews, 65 p.p 104-120, 2013.
6- Lehár J., Krueger A.S., Avery W., Heilbut A.M., Johansen L.M., Price E.R., Rickles R.J., Short Iii G.F., Staunton J.E., Jin X., “Synergistic drug combinations tend to improve therapeutically relevant selectivity”, Nature biotechnology, 2009; 27:659-666.
7- Wan-Wan Y. and Erik P.f, “Reservoir-Based Polymer Drug Delivery Systems”, Journal of Laboratory Automation, 17(1) 50–58, 2012.
8- Ndidi C. Ngwuluka, Nelson A. Ochekpe and Okezie I. Aruoma, “Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery”, polymers, 2014; 6:1312-1332.
9- Ololade O., “Natural Polymers Industry Techniques and Applications”, University of Lagos, Nigeria, Springer International Publishing Switzerland, p 63, 2016.
10- Ridley B.L., O'Neill MA, and Mohnen D, Pectin: structure, biosynthesis, and oligogalacturonide-related signaling. Phytochemistry, 2001; 57(6):929-67.
11- Fischer R.L. and A.B. Bennett, Role of Cell Wall Hydrolases in Fruit Ripening. Annual Review of Plant Physiology and Plant Molecular Biology, 1991; 42:675-703.
12- Mort A.J., F. Qiu, and N.O. Maness, Determination of the pattern of methyl esterification in pectin. Distribution of contiguous nonesterified residues. Carbohydr Res, 1993; 247:21-35.
13- Ralet M.C., et al., Mapping sugar beet pectin acetylation pattern. Phytochemistry, 2005; 66(15):1832-43.
14- Levigne S., M.C. Ralet, and J.F. Thibault, Characterisation of pectins extracted from fresh sugar beet under different conditions using an experimental design. Carbohydr Polymers, 2002; 49(2).
15- Rolin C., Commercial Pectin Preparations, in Pectin and Their Manipulation, G.B. Seymour and J.P. Knox, Editors. 2002. p. 222-239.
16- Rahul V. M., Olobayo O. K., Martins O. E., Bill K., (Physical, thermal and sorption profile of starch obtained from tacca leontopetaloides), Starch - Stärke, 2005; 57(2):55-61.
17- Dumitiu S. (Polysaccharides-structural diversity and functional versatility), 2nd ed , Library of Congress, New York, (2005).
18- Roper H., (Applications of starch and its derivatives), Carbohydr Eur. 1996; 15:14-21.
19- Vilivalam V.D., Illum L., Iqbal K., (Starch capsules: an alternative system for oral drug delivery), Pharm. Sci. Technol. Today, 2000; 3(2):64- 69.
20- Milojevic S., Newton J.M., Cummings J.H., Gibson G.R., Botham R.L., Ring S.G.,Stockham M.,Allwood M.C. , (Amylose as a coating for drug delivery to the colon: preparation and in vitro evaluation using 5-aminosalicylic acid pellets), J. Control. Release. 1996; 38:75-84.
21- Désévaux C., Dubreuil P., Lenaerts V., Girard C., (Tissue reaction and biodegradation of implanted cross-linked high amylose starch in rats), J. Biomed. Mater. Res. 2002; 63(6):772-779.
22- Mulhbacher J., Ispas-Szabo P., Lenaerts V., Mateescu M.A., (Cross-linked high amylose starch derivatives as matrices for controlled release of high drug loadings), J. Control. Rel, 2001; 76:51-58.
23- Nabais T., Brouillet F., Kyriacos S., Mroueh M., Amores da Silva P.,Bataille B., Chebli C., Cartilier L.,( High-amylose carboxymethyl starch matrices for oral sustained drug-release: in vitro and in vivo evaluation), Eur. J. Pharm. Biopharm, 2007; 65:371-378.
24- Teramoto N., Motoyama T., Yosomiya R.,Shibata M. ,(Synthesis, thermal properties, and biodegradability of propyl-etherified starch,) Eur. Polym. J., 2003; 39:255-261.
25- Araújo M.A., Cunha A., Mota M., (Enzymatic degradation of starch-based thermoplastic compounds used in protheses: identification of the degradation products in solution,) Biomaterials, 2004; 25(13):2687-2693.
26- Zhang J.F., Sun X.Z., (Mechanical properties of PLA/starch composites compatibilized by maleic anhydride), Biomacr- omolecules, 2004; 5(4):1446-1451.
27- Pareta R., Edirisinghe M.J., (A novel method for the preparation of starch films and coatings), Carbohydr. Polym, 2006; 63:425-431.
28- Burr R.C., Fanta G.F., Doane W.M., Russell C.R., (Graft copolymers of starch and mixtures of acrylamide and acrylic acid), Journal of Applied Polymer Science, 1976; 20:3201-3204.
29- Trimnell D., Stout E.I., (Grafting acrylic acid onto starch and poly (vinyl alcohol) by photolysis), J. Appl. Polym. Sci., 1980; 25(10):2431-2434.
30- Park I.H., Song S.Y., Song B.K., (Gratf polymerization of acrylic acid onto corn starch in aqueous isopropanol solution), Macro. Mat. Eng., 1999; 267(1):20-26.
31- Mohammad S., (Synthesis of starch-g-poly (acrylic acid-co-2- hydroxy ethyl methacrylate) as a potential pH-sensitive hydrogel- based drug delivery system), Turk J Chem, 2011; 35:723-733.
32- Deepak P., Reena S., (Synthesis and characterization of graft copolymers of methacrylic acid onto gelatinized potato starch using chromic acid initiator in presence of air), Adv. Mat. Let., 2012; 3(2):136-142.
33- Armitage P, (2005) Statistical methods in medical research in blank well scientific Publication,USA(1971) Claremunt, M, A. Garcia, Conception Lapez and Jose Elguero, ARKIVOC (vii),91.
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