CONTROLLED DRUG RELEASE OF GRAFTED PECTIN
Modification of Pectin as natural polymer was accepted as new bio adhesive polymer, which was grafted with Maleic anhydride as vinylic monomore and insertion by using ceric ion it, was substituted with amino drugs produced amide polymer which do not lose their biological properties. This design carries controlled delivery which could release the entrapped drug over an extended period of time due to its slow digesting nature. The prepared adhesive drug polymer was characterized by FTIR, 1H-NMR spectroscopes, thermo gravimetric analysis TGA and DSC were careful. Physical properties of prepared polymer was quiet, Biological activity was studied for adhesive drug polymer, this new adhesive drug biological polymers were applied on different infected mice and wounds, It gave outstanding results and compliance mice infected with a full recovery by a short period of time. The prepared drug copolymer was analyzed in different pH values at 37 0C in vitro study and controlled drug release was messured through three days. The rate of hydrolysis in basic medium was found higher than acidic medium. It was concluded that modified drug release with extended drug action via slow release and in vivo performance was renowned to be talented.
Keywords: Pectin, controlled delivery, adhesive drug polymers, Graft Copolymer
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