Formulation and evaluation of in situ herbal gel containing aqueous and methanolic extract of fruits of Quercus infectoria Oliv. for vaginal application
Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the development of innovative vaginal formulation technology that fulfills certain criteria such as desirable product dispersion throughout the vagina, retention for intended intervals, and adequate release of drug. These features can be achieved by the use of bioadhesive based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of an antifungal drug to formulated In-situ gel. Quercus infectoria is medicinally important plant grown wildly in India and is useful in the treatment of fungal and microbial infection by tribal’s of India. The plant is used by tribal women to treat vaginal infection as mentioned in folk-lore. Therefore, the present plant as selected to formulate in-situ herbal gel using Quercus infectoria as active ingredients for the treatment of vaginal infection.
Keywords: Herbal Gels, Quercus infectoria, bioadhesive, vaginal drug delivery
2. Jain S.K., Jain N.K., Gupta Y., Jain A., Jain D. and Chaurasia M. Mucoadhesive chitosan microspheres for non-invasive and improved nasal delivery of insulin. International Journal of Pharmaceutics. 2007; 64:498–504.
3. William R. Vaginal Microbicide Formulation Workshop. Virginia: Contraceptive Research and Development Program Arlington. 1998.
4. Merabet J., Thompson D., Saul Levinson R.. Advancing vaginal drug delivery. Expert Opin Drug Deliv. 2005; 2:769–77.
5. Kottakkal AVS. Indian Medicinal Plants. 4. Orient Longman Ltd. 1995.
6. Bhattacharjee SK. Handbook of Medicinal Plants. India: Pointer Publishers. 2001.
7. Evans WC Pharmacopoeial and related drugs of biological origin. London: WB Saunders Co. Ltd. 1996.
8. Wiart C. and Kumar A. Practical Handbook of Pharmacognosy. Malaysia: Pearson Education Malaysia Sdn Bhd. 2001.
9. Ikram M. and Nowshad F. Constituents of Quercus infectoria. Planta Med 1977; 31:286–287.
10. Hwang J.K., Kong T.W., Baek, N.I. and Pyun Y.R. alpha-Glycosidase inhibitory activity of hexagalloylglucose from the galls of Quercus infectoria. Planta Med 2000; 66:273–274.
11. Kaur G., Hamid H., Ali A., Alam M.S. and Athar M. Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoria. J Ethnopharmacol 2004; 90:285–292.
12. Kaur G., Athar M. and Alam M.S. Quercus infectoria galls possess antioxidant activity and abrogates oxidative stress-induced functional alterations in murine macrophages. Chem Biol Interact 2008; 171:272–282.
13. Sawangjaroen N., Sawangjaroen K. and Poonpanang P. Effects of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall on caecal amoebiasis in mice. J Ethnopharmacol 2004; 91:357–360.
14. Chusri S. and Voravuthikunchai S.P. Quercus infectoria: a candidate for control of methicillin-resistant Staphylococcus aureus infections. Phytother Res 2008; 22, doi: 10:1002 ⁄ ptr.2377..
15. Dwivedi S. Status survey of medicinal plants wealth of Malwa region of Madhya Pradesh with special reference to conservation of vulnerable and endangered species, J. Econ. Taxon. Bot., 2009; 33(2):443-452.
16. Saeida N, Hasmah A, Amilah WN. Potential use of Quercus infectoria galls extracts against urinary tract pathogenic bacteria. Int J. of Res. In Pharmacology & Pharmacotherapeutics, 2014; 3(3):184-191.
17. Patel P. and Papel P. Formulation and evaluation of clindamycin HCL in situ gel for vaginal application. Int J Pharm Investig.; 2015; 5(1):50–56.
18. Masoudi M, Miraj S, Rafieian-Kopaei M. Comparison of the Effects of Myrtus Communis L, Berberis Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis. J Clin Diagn Res. 2016; 10(3):QC04-7.
19. Rençber S, Karavana SY, Şenyiğit ZA, Eraç B, Limoncu MH and Baloğlu E. Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation. Pharm Dev Technol., 2017; 22(4):551-561
20. Bhinge SD, Bhutkar MA, Randive DS, Wadkar GH, Todkar SS, Kakade PM and Kadam PM Formulation development and evaluation of antimicrobial polyherbal gel. Ann Pharm Fr. 2017; 75(5):349-358.
21. Khanbabaee K, van Ree T. Tannins: Classification and definition. Nat Prod Rep. 2001; 18:641–9.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).