Synthesis, characterization of 2-substituted benzimidazole derivatives and evaluation of antimicrobial activity

  • M Shahnaz Shivalik College of Pharmacy, Nangal, Punjab, India
  • Parminder Kaur Shivalik College of Pharmacy, Nangal, Punjab, India
  • J Parkash Shivalik College of Pharmacy, Nangal, Punjab, India
  • DN Parsad Shivalik College of Pharmacy, Nangal, Punjab, India

Abstract

Benzimidazole has attracted a great deal of importance due to their interesting chemistry and wide utility. Benzimidazole has wide range of uses and applications and is produced in great quantities throughout the world. The current research work was aim to evaluate the in vitro antifungal activity of series of benzimidazole derivatives. A series of benzimidazole derivatives were synthesized by reacting the various amine derivatives of o phenylene diame with carbon disulphide in presence of Potassium hydroxide. All the bis derivatives were characterized by IR, 1H NMR and chromatography method (TLC). The antibacterial activity was evaluated by their MIC and zone of inhibition of synthesized compounds by taking ciprofloxacin as reference standard. The microbiological assay revealed that the compounds show promising antibacterial activity.


Keywords: Ciprofloxacin, Benzimidazole, antibacterial activity.

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Author Biographies

M Shahnaz, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

Parminder Kaur, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

J Parkash, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

DN Parsad, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

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How to Cite
Shahnaz, M., Kaur, P., Parkash, J., & Parsad, D. (2018). Synthesis, characterization of 2-substituted benzimidazole derivatives and evaluation of antimicrobial activity. Journal of Drug Delivery and Therapeutics, 8(5), 460-464. https://doi.org/10.22270/jddt.v8i5.1909