Physicochemical and Microbiological Assays for Quality Evaluation of a Brand of Mentha piperita Tisanes in Costa Rica Market: Employment of the Central American Technical Regulation

  • Juan José Mora Román Industrial Pharmacy Departament, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Natalia Agüero Brenes Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Camila Angulo Morales Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Jose Castro Solís Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Gabriela Hidalgo Carrillo Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Gómez Mónica van Hoof Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Arlene Loría Gutiérrez Pharmacology, Toxicology and Pharmacodependence Departament, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.
  • Jeimy Blanco Barrantes Laboratory of Pharmaceutical Analysis and Assessment (LAYAFA), Universidad de Costa Rica, San José, Costa Rica.

Abstract

Mentha piperita is a natural hybrid of water mint (Mentha aquatica) and spearmint (Mentha spicata L.), that are consumed as tisanes. For that reason, the present work evaluated physicochemical and microbiological aspects for the quality control of a commercial brand of Mentha piperita herbal tea distributed in Costa Rica, using assays established by the Central American Technical Regulation (RTCA) 11.03.56.09 (Pharmaceutical products. Natural medicinal products for human use. Quality verification), and determined if they have uniformity for different batches of this brand. To verify the quality of three batches of this product, the following assays were done: Labeling requirements, organoleptic, minimum fill, foreign organic matter, loss on drying, total ash, acid-insoluble ash, lead and arsenic limits, microbial enumerations and specific microorganisms (E. coli and Salmonella sp.) assays. As conclusion, the batches were in compliance for all the assays, except for labeling test, since information corresponding to the primary (batch number and expiration date) and secondary packaging (qualitative-quantitative composition of active ingredients interactions and adverse effects) were not presented. Furthermore, one of the batches did not have information about the employment, contraindications and warnings. Also, the manufacturing company maintained a good reproducibility between one batch and another, and the improvements that can be made are in the product labeling and better controls in its filling.


Keywords: Natural product, Mentha piperita, quality control, tisane, pharmacopoeia, Central American Technical Regulation.

Keywords: Mentha piperita

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Author Biographies

Juan José Mora Román, Industrial Pharmacy Departament, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Industrial Pharmacy Departament, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Natalia Agüero Brenes, Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Camila Angulo Morales, Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Jose Castro Solís, Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Gabriela Hidalgo Carrillo, Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Gómez Mónica van Hoof, Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Pharmacy Student, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Arlene Loría Gutiérrez, Pharmacology, Toxicology and Pharmacodependence Departament, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Pharmacology, Toxicology and Pharmacodependence Departament, Faculty of Pharmacy, Universidad de Costa Rica, San José, Costa Rica.

Jeimy Blanco Barrantes, Laboratory of Pharmaceutical Analysis and Assessment (LAYAFA), Universidad de Costa Rica, San José, Costa Rica.

Laboratory of Pharmaceutical Analysis and Assessment (LAYAFA), Universidad de Costa Rica, San José, Costa Rica.

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Mora Román, J. J., Agüero Brenes, N., Angulo Morales, C., Castro Solís, J., Hidalgo Carrillo, G., van Hoof, G. M., Loría Gutiérrez, A., & Blanco Barrantes, J. (2018). Physicochemical and Microbiological Assays for Quality Evaluation of a Brand of Mentha piperita Tisanes in Costa Rica Market: Employment of the Central American Technical Regulation. Journal of Drug Delivery and Therapeutics, 8(5), 329-337. https://doi.org/10.22270/jddt.v8i5.1878