PROTECTIVE EFFECT OF A TRADITIONAL MEDICINE, RUTIN, AGAINST LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA IN MICE
Abstract
Lipopolysaccharide (LPS) is a main causative agent of septic shock. In this study we investigated the possible effects of Rutin (RT) against LPS-induced endotoxemia model in vivo to determine whether RT could rescue mice from ensuing death after their exposure to LPS. To further understand the role of RT, the responses of cytokines were also assessed in serum isolated from blood collected at 0, 1.5, 3, 6, and 12h after LPS administration of the mice. In the study, RT showed suppressive effects on TNF-α, IL-6, and IL-1β production by LPS- challenged mice. Furthermore, RT protected mice by improving host survival against LPS challenge. The present ï¬ndings reinforce the potential of RT, a natural compound as drug candidate for prevention of sepsis progression.
Keywords: Rutin, lipopolysaccharide, cytokine, sepsis, mice
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