PROTECTIVE EFFECT OF A TRADITIONAL MEDICINE, RUTIN, AGAINST LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA IN MICE

  • Lanan Wassy Soromou Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée
  • Morlaye Kindia Sylla Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée
  • Mohamed Keyra Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée
  • Youssouf Sidime Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Abstract

Lipopolysaccharide (LPS) is a main causative agent of septic shock. In this study we investigated the possible effects of Rutin (RT) against LPS-induced endotoxemia model in vivo to determine whether RT could rescue mice from ensuing death after their exposure to LPS. To further understand the role of RT, the responses of cytokines were also assessed in serum isolated from blood collected at 0, 1.5, 3, 6, and 12h after LPS administration of the mice. In the study, RT showed suppressive effects on TNF-α, IL-6, and IL-1β production by LPS- challenged mice. Furthermore, RT protected mice by improving host survival against LPS challenge. The present ï¬ndings reinforce the potential of RT, a natural compound as drug candidate for prevention of sepsis progression.

Keywords: Rutin, lipopolysaccharide, cytokine, sepsis, mice

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Author Biographies

Lanan Wassy Soromou, Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Morlaye Kindia Sylla, Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Mohamed Keyra, Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Youssouf Sidime, Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

Institut supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, République de Guinée

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1.
Soromou L, Sylla M, Keyra M, Sidime Y. PROTECTIVE EFFECT OF A TRADITIONAL MEDICINE, RUTIN, AGAINST LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA IN MICE. JDDT [Internet]. 24Jan.2018 [cited 18Jan.2021];8(1):108-13. Available from: http://jddtonline.info/index.php/jddt/article/view/1675