PROTECTIVE EFFECT OF A TRADITIONAL MEDICINE, RUTIN, AGAINST LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA IN MICE
Abstract
Lipopolysaccharide (LPS) is a main causative agent of septic shock. In this study we investigated the possible effects of Rutin (RT) against LPS-induced endotoxemia model in vivo to determine whether RT could rescue mice from ensuing death after their exposure to LPS. To further understand the role of RT, the responses of cytokines were also assessed in serum isolated from blood collected at 0, 1.5, 3, 6, and 12h after LPS administration of the mice. In the study, RT showed suppressive effects on TNF-α, IL-6, and IL-1β production by LPS- challenged mice. Furthermore, RT protected mice by improving host survival against LPS challenge. The present ï¬ndings reinforce the potential of RT, a natural compound as drug candidate for prevention of sepsis progression.
Keywords: Rutin, lipopolysaccharide, cytokine, sepsis, mice
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References
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27. Remus JL, Dantzer R. Inflammation Models of Depression in Rodents: Relevance to Psychotropic Drug Discovery. Int J Neuropsychopharmacol. 2016; 19(9): pyw028.
2. Ren Y, Xie Y, Jiang G, Fan J, Yeung J, Li W, Tam PK, Savill J. Apoptotic cells protect mice against lipopolysaccharide-induced shock. J Immunol. 2008; 180(7):4978-85.
3. Namas R, Ghuma A, Hermus L, R Zamora, DO Okonkwo, TR Billiar, et al. The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: Current state and emerging prospects. Libyan J. Med. 2009; 4:97–103.
4. Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, et al. Bacterial lipopolysaccharide activates nuclear factor- B through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 1999; 274: 7611–7614.
5. Van der Watt E, Pretorius JC. "Purification and identification of active antibacterial components in Carpobrotusedulis L." Journal of Ethnopharmacology. 2001; 76 (1):87–91.
6. Kurisawa M, Chung JE, Uyama H, Kobayashi S. Enzymatic synthesis and antioxidant properties of poly (rutin). Biomacromolecules 2003; 4:1394–1399
7. Choi SJ, Lee SN, Kim K, Joo da H, Shin S, Lee J, et al. Biological effects of rutin on skin aging. Int J Mol Med. 2016; 38 (1):357-63.
8. Lu N, Ding Y, Yang Z, Gao P. Effects of rutin on the redox reactions of hemoglobin International Journal of Biological Macromolecules 2016, 89:175-180
9. The Natural Health Benefits of Rutin https://jonbarron.org/herbal-library/nutraceuticals/rutin
10. Sharma S, Ali A, Ali J, Sahni JK, Baboota S. Rutin: therapeutic potential and recent advances in drug delivery. Expert Opin Investig Drugs. 2013; 22(8):1063-79.
11. Ueno T, Ikeda T, Ikeda K, Taniuchi H, Suda S, Yeung MY, Matsuno N.. HMGB-1 as a useful prognostic biomarker in sepsis-induced organ failure in patients undergoing PMX-DHP. J Surg Res 2011;171:183e90
12. Bone RC: The sepsis syndrome: Definition and general approach to management. Clin Chest Med 1996, 17:175-181.
13. Astiz ME, Rackow EC: Septic shock. Lancet 1998, 351:1501-1505.
14. Fairweather D, Rose NR: Inflammatory heart disease: a role for cytokines. Lupus 2005; 14:646-651.
15. Parrillo JE, Parker MM, Nathanson C, Suffredini AF, Danner RL, Cunnion RE, et al. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann. Intern. Med. 1990; 113:227–242.
16. Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420:885–891.
17. Benjamim CF, Hogaboam CM, Kunkel SL. The chronic consequences of severe sepsis. J. Leukocyte Biol. 2004; 75:408–412.
18. Soares MBP, Bellintani MC, Ribeiro IM, Tomassini TCB, Santos RR. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids puriï¬ed from Physalis angulata L. Eur J Pharmacol 2003; 459:107–12.
19. Tsiotou AG, Sakorafas GH, Anagnostopoulos G, Bramis J. Septic shock; current pathogenic concepts from a clinical perspective. Med Sci Monit 2005; 11:76–85.
20. Lamontagne F, Meade M, Ondiveeran HK, Lesur O, Robichaud AR. Nitric oxide donors in sepsis: a systematic review of clinical and in vivo preclinical data. Shock 2008; 30:653–9.
21. Rios-Santos F, Benjamim CF, Zavery D, Ferreira SH, Cunha Fde Q. A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. Shock 2003; 19: 61– 65.
22. Enomoto N, Takei Y, Hirose M, Kitamura T, Ikejima K, Sato N. Protective effect of thalidomide on endotoxin-induced liver injury. Alcohol Clin. Exp. Res. 2003; 27: 2S– 6S.
23. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004; 202:145–156.
24. Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005; 41:2502–2512.
25. Giebelen IA, van Westerloo DJ, LaRosa GJ, de Vos AF, van der Poll T. Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung. Shock 2007; 28:700–703.
26. Kielian T, McMahon M, Bearden ED. , Baldwin AC, Drew PD, Esen N.S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Δ12,14- prostaglandin J2 (15d-PGJ2). J Neurochem. 2004 Sep; 90(5): 1163–1172.
27. Remus JL, Dantzer R. Inflammation Models of Depression in Rodents: Relevance to Psychotropic Drug Discovery. Int J Neuropsychopharmacol. 2016; 19(9): pyw028.
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1.
Soromou L, Sylla M, Keyra M, Sidime Y. PROTECTIVE EFFECT OF A TRADITIONAL MEDICINE, RUTIN, AGAINST LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA IN MICE. JDDT [Internet]. 24Jan.2018 [cited 20May2024];8(1):108-13. Available from: https://jddtonline.info/index.php/jddt/article/view/1675
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