IN-VIVO ANTIOXIDANT EFFECT OF ABROMA AUGUSTA IN DIABETES INDUCED OXIDATIVE STRESS
Abstract
The present study was aimed to investigate the In-vivo antioxidant activity of roots of Abroma augusta in streptozotocin-nicotinamide induced Type-II diabetes. The extraction (Hot continuous extraction process) was carried out with solvents of different polarity. Commercially available Vit-E (100 mg/kg b.w.) was used as a standard drug. In-vivo antioxidant activity of plant extracts (250 mg/kg b.w.) was assessed by measuring SOD, CAT and LPO in the blood of Type-II diabetic animals. The results of the study revealed the significant effect on SOD, CAT and LPO level in animals treated with petroleum ether extract (p<0.0001) followed by aqueous extract (p<0.001) of A. augusta significantly as compared to diabetic control. The results of the study suggested the antioxidant activity of plant extract which prevents from oxidative stress and provide protection to vital tissues like liver, kidney, heart etc.
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