DEVELOPMENT OF CLARITHROMYCIN GASTRORETENTIVE MICROSPHERES

  • Priya Jain IPS Academy College of Pharmacy, Indore (M.P.) 452012, India
  • Dinesh Kumar Jain IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

Abstract

Gastroretentive microspheres of clarithromycin were prepared on the principle of cation induced gelification using sodium alginate and pectin. These microspheres were investigated for micromeritic properties, drug entrapment, mucoadhesion and drug release properties. Microspheres were found to be discrete, spherical and free flowing. Microspheres were found to adhere to gastric mucosa with high affinity and showed controlled drug release.

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Author Biographies

Priya Jain, IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

Dinesh Kumar Jain, IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

IPS Academy College of Pharmacy, Indore (M.P.) 452012, India

References

1. Rajaonarivony M, Vauthier C, Couarraze G, Development of a new drug carrier made from sodium alginate, JPS, 1993, 82, 912–917.
2. Tripathi GK, Formulation and evaluation pH stimuli sensitive multiparticulate delivery system of Clarithromycin for the treatment Of Helicobacter pylori, IJPTR, 2013, 5, 7-16.
3. Lehr CM, Bouwstra JA, Schacht EH, Junginger HE, In vitro evaluation of mucoadhesive properties of chitosan and some other polymers, IJP, 1992, 78, 43-48.
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How to Cite
Jain, P., & Jain, D. (2017). DEVELOPMENT OF CLARITHROMYCIN GASTRORETENTIVE MICROSPHERES. Journal of Drug Delivery and Therapeutics, 7(7), 81-83. https://doi.org/10.22270/jddt.v7i7.1594