ANTIDIABETIC ACTIVITY OF BAUHINIA VARIEGATA EXTRACTS IN ALLOXAN-INDUCED DIABETIC RATS

  • Himanshu Gurjar Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India-211007
  • Himanshu Pandey Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India-211007
  • Amita Verma Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottam University of Agriculture, Technology and Sciences, Allahabad, India-211007
  • Raghuveer Irchhaiya Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India
  • Prem Prakash Singh Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India

Abstract

Bauhinia variegata commonly known as kachnar tree and is cultivated throughout India. literature survey revealed that the leaf of Bauhinia variegata is traditionally used as an astringent in diabetes. flowers are laxative.the present study was undertaken to evaluate the antidiabetic activity of ethanol extract of leaf of  Bauhinia variegata extract was evaluated using albino wister rat i.e.alloxan induced diabetes in albino wister rat by glucometer method, with 50 mg/kg,100 mg/kg and 200 mg/kg and higher doses showed significant value represent at table no and figure 1,2,3,4 respectively with different successive extract and show the significant p value.

Keyword: Bauhinia Variegata, Ethanolic Extract, Antidiabetic, Alloxan, Albino Wister Rat

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Author Biographies

Himanshu Gurjar, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India-211007

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of  Agriculture, Technology and  Sciences, Allahabad, India-211007

Himanshu Pandey, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India-211007

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottam University of  Agriculture, Technology and  Sciences, Allahabad, India-211007

Amita Verma, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottam University of Agriculture, Technology and Sciences, Allahabad, India-211007

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottam University of  Agriculture, Technology and  Sciences, Allahabad, India-211007

Raghuveer Irchhaiya, Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India
Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India
Prem Prakash Singh, Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India
Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India

References

1. National Diabetes Data Group Diabetes in America, 2nd edition. Bethesda, M.D. National Institutes of Health, National Institute of Diabetes Goodman and Gillman, “The Pharmacological basis of therapeutics”, Mcgrow hills publication, 2001, 11, 1679-1714.
2. Canadian Diabetes Association (CDA), “Can. J. diabetes”, 2003; 27(Suppl 2):S1-152.
3. American Diabetes Association (ADA)., “Diabetes Care”, 2005; 28(SI):S4-36.
4. Khan A. Irfan, Khanum Atiya “Herbal therapy for Diabetes”, Ukaaz publication, Hyderabad, 2005; 1(1):122-38.
5. Khandelwal KR, “Practical Pharmacognosy”, Nirali Prakashan, 149-155.
6. Kirtikar and Basu., “Indian Medicinal Plants”, 2000; 6:93-95.
7. Kumar D, ParchaV, Maithani A and Dhulia I: Effect and evaluation of Antihyperlipidemic activity of fractions of total methanol extract of Bauhinia Variegata (Linn.) leaves on Triton WR-1339 (Tyloxapol) induced hyperlipidemic rats. Int J Res Pharm Sci 2011; 2(4):493-497.
8. Marasani A, Kavitha N Ch, Babu MS; Antistress/Adaptogenic Activity of Bauhinia variegata Against Different Stress Paradigms. International journal of Pharmaceutical & biological archives 2013; 4(5):956 – 964.
9. Pandey AK, Mishra A, Sharma AK, Saxena SK, Ajit S, Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities. Hindawi publishing corporation biomed research international 2013; Article ID 915436, page no.10.
10. Ghaisas MM, Shaikh SA, Deshpande AD: Evaluation of immunomodulatory activity of ethanolic extract of the stem bark of Bauhinia variegata Linn. Int. J. of Green Pharmacy 2009; 70-74.
11. Pathak S, Sahu G, Jain S.K: Hepatoprotective activity of ethanolic extract of Bauhinia Variegata leaves. Pharmacologyonline 2011; 3:721-728.
12. Chourasiya A, Upadhaya A, Shukla RN, Isolation of quercetin- from leaves of Azadirachta Indica and anti-diabetic study of the crude extracts. Journal of pharmaceutical and biomedical science 2012; December 25(25):179-181.
13. Bansal V, Malviya S, Malaviya D, Sharma PK, Phytochemical, Pharmacological Profile and Commercial Utility of Tropically Distributed Plant Bauhinia Variegata. Global Journal of Pharmacology; 2014; 8(2):198.
14. Ali Esmail Al-Snafi: The Pharmacological Importance of Bauhinia Variegata. A Review International Journal of Pharma Sciences and Research (IJPSR); 2013; 4(12):160-164.
15. Ansari SH, “Essential of Pharmacognosy”, Birla Publication, 2005; 1:591-592.
16. Mukharjee PK., “Evaluation of Indian Traditional medicine”, J. Drug Information, USA, 2001; 35:631-640.
17. Kokate CK, Purohit AP, Gokhale SB, Pharmacognosy, 2010; Sixth edition: 1.2-1.5.
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Gurjar H, Pandey H, Verma A, Irchhaiya R, Singh P. ANTIDIABETIC ACTIVITY OF BAUHINIA VARIEGATA EXTRACTS IN ALLOXAN-INDUCED DIABETIC RATS. JDDT [Internet]. 14Jan.2018 [cited 8Dec.2021];8(1):29-2. Available from: http://jddtonline.info/index.php/jddt/article/view/1548