NATURAL PRODUCTS USED AS ANTI-CANCER AGENTS
Abstract
In the present time Natural products are considered to be symbols of protection in comparison to the synthetic product that are regarded as unsafe to human life and environment. Although a large number of synthetic drugs are being added to the world of present pharmacopoeia, but still no system of medicine in the world has been able to solve all the health problems, which include diseases like Cancer. Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, derived from epipodophyllotoxin, and paclitaxel (taxol). Several promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, and some agents which failed in earlier clinical studies are stimulating renewed interest. Therefore the search for innovative therapeutic constituents from plants is genuine and urgent. In India, there is an ocean of knowledge about medicinal plants and rich medicinal flora, but still only a few pearls have been searched as therapeutic agents.
Key words: Cancer, Anti-cancer agents, Natural Plant
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References
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35. Xu L, Lao LX, Ge A, Yu S, Li J, Mansky PJ, Chinese herbal medicine for cancer pain, Integrative Cancer Therapies, 2007, 6(3), 208-34.
36. Gonzales GF, Valerio LG, Medicinal plants from Peru: a review of plants as potential agents against cancer, Anti-Cancer Agents in Medicinal Chemistry, 2006, 6(5), 429-44.
37. Hu KW, Li QW, Zuo MH, Sun T, Jiang M, Clinical observation on the combined treatment of 57 cases of non-small cell lung cancer using argon-helium cryosurgery and Chinese herbal medicine, Chinese journal of integrative medicine, 2007, 13(3), 224-7.
38. Wang F, Gao Y, Gao L, Xing T, Study on the electrochemical behavior of the anticancer herbal drug berberine and its analytical application, Journal of the Chinese Chemical Society, 2011, 58(4), 450-6.
39. Patil JB, Kim J, Jayaprakasha GK, Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway, European journal of pharmacology, 2010, 645(1), 70-8.
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2. Nirmala MJ, Samundeeswari A, Sankar PD, Natural plant resources in anti-cancer therapy-A review, Research in Plant Biology, 2011, 1(3), 23-31
3. Sarangi MK, Padhi S, Plants with potential anticancer activities-a Review, International Journal of Phytomedicine, 2014, 6(1), 01.
4. Dholwani KK, Saluja AK, Gupta AR, Shah DR, A review on plant-derived natural products and their analogs with anti-tumor activity, Indian journal of pharmacology, 2008, 40(2), 49.
5. Ghersi D, Wilcken N, Simes RJ, A systematic review of taxane-containing regimens for metastatic breast cancer, British journal of cancer, 2005, 93(3), 293-301.
6. Bailey KM, Wojtkowiak JW, Hashim AI, Gillies RJ, Targeting the metabolic microenvironment of tumors, Advances in pharmacology, 2012, 65:63.
7. Nema R, Khare S, Jain P, Pradhan A, Gupta A, Singh D, Natural products potential and scope for modern cancer research, American journal of plant sciences, 2013, 4, 1270-1277
8. Tsukagoshi S, Hashimoto Y, Fujii G, Kobayashi H, Nomoto K, Orita K. Krestin (Psk), Cancer treatment reviews, 1984, 11(2), 131-55.
9. Agarwal D, Ranawat MS, Chauhan CS, Kamble R, Formulation And Charecterisation Of Colon Targeted pH Dependent Microspheres Of Capecitabine For Colorectal Cancer, Journal of Drug Delivery and Therapeutics. 2013; 3(6):215-222
10. de Aquino PF, Nunez EL, Sánchez A, Panno R, de Oliveira B, Ayres AF, Nogueira FC, Domont GB, Carvalho PC, Unraveling the gastric cancer proteomic landscape with isobaric markers, America, 2013, 42(2), 261-84.
11. Cragg GM, Newman DJ, Plants as a source of anti-cancer agents, Journal of ethnopharmacology, 2005, 100(1), 72-9.
12. Leveque D, Jehl F, Molecular pharmacokinetics of catharanthus (vinca) alkaloids, The Journal of Clinical Pharmacology, 2007, 47(5), 579-88.
13. Aapro MS, Conte P, Gonzalez EE, Trillet-Lenoir V, Oral vinorelbine, Drugs, 2007, 67(5), 657-67.
14. Yun-San Yip A, Yuen-Yuen Ong E, Chow LW, Vinflunine: clinical perspectives of an emerging anticancer agent, Expert opinion on investigational drugs, 2008,17(4), 583-91.
15. Shoeb M. Montamine, a unique dimeric indole alkaloid, from the seeds of Centaurea Montana (Asteraceae), and its in-vitro cytotoxic activity against the CaCo2 colon cancer cells, Tetrahedron, 2006, 62, 72-77.
16. Thomson M, Ali M, Current Cancer Drug Targets, 2003, 3(1), 67-81
17. Kingston DGI, The shape of things to come: structural and synthetic studies of taxol and related compounds, Photochemistry, 2007, 68 (14), 1844-1854.
18. Hait WN, Rubin E, Alli E, Goodin S, Tubulin targeting agents, Update on cancer therapeutics, 2007, 2(1), 1-8.
19. Lorence A, Medina-Bolivar F, Nessler CL, Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots, Plant Cell Reports, 2004, 22(6), 437-41.
20. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O, Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle, Frontiers in aging neuroscience, 2014, 6:245.
21. Kang JH, Song KH, Woo JK, Park MH, Rhee MH, Choi C, Oh SH, Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells, Plant Foods for Human Nutrition, 2011, 66(3):298-305.
22. Chik WW, Amid A, Jamal P, Purification and cytotoxicity assay of tomato (Lycopersicon esculentum) leaves methanol extract as potential anti-cancer agent, Journal of Applied Sciences, 2010, 10(24), 3283-8.
23. Waheed Roomi M, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M, In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549, Experimental lung research, 2006, 32(9), 441-53.
24. Pastore RL, Fratellone P, Potential health benefits of green tea (Camellia sinensis): a narrative review. Explore, 2006, 2(6), 531-9.
25. Hide M, Francis DM, Grattan C, Hakimi J, Kochan JP, Greaves MW, Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria, New England Journal of Medicine, 1993, 328(22), 1599-604.
26. Dubey KK, Ray AR, Behera BK, Production of demethylated colchicine through microbial transformation and scale-up process development, Process Biochemistry, 2008, 43(3), 251-7.
27. Son YO, Kim J, Lim JC, Chung Y, Chung GH, Lee JC, Ripe fruits of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells, Food and Chemical Toxicology, 2003, 41(10), 1421-8..
28. Molavi O, Ma Z, Mahmud A, Alshamsan A, Samuel J, Lai R, Kwon GS, Lavasanifar A, Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors, International journal of pharmaceutics, 2008, 347(1), 118-27.
29. Bernard SA, Olayinka OA, Search for a novel antioxidant, anti-inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace, Journal of Medicinal Plants Research, 2010, 4(25), 2821-6.
30. Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB, Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?, Journal of the national cancer institute, 2008, 100(11), 773-83.
31. Ye B, Aponte M, Dai Y, Li L, Ho MC, Vitonis A, Edwards D, Huang TN, Cramer DW, Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence, Cancer letters, 2007, 251(1), 43-52.
32. Thomson P, Naylor MA, Everett SA, Stratford MR, Lewis G, Hill S, Patel KB, Wardman P, Davis PD, Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4, Molecular cancer therapeutics, 2006, 5(11), 2886-94.
33. Ley CD, Horsman MR, Kristjansen PE, Early effects of combretastatin-A4 disodium phosphate on tumor perfusion and interstitial fluid pressure, Neoplasia, 2007, 9(2), 108-12.
34. Hazra B, Sarma MD, Sanyal U, Separation methods of quinonoid constituents of plants used in Oriental traditional medicines, Journal of Chromatography B, 2004, 812(1), 259-75.
35. Xu L, Lao LX, Ge A, Yu S, Li J, Mansky PJ, Chinese herbal medicine for cancer pain, Integrative Cancer Therapies, 2007, 6(3), 208-34.
36. Gonzales GF, Valerio LG, Medicinal plants from Peru: a review of plants as potential agents against cancer, Anti-Cancer Agents in Medicinal Chemistry, 2006, 6(5), 429-44.
37. Hu KW, Li QW, Zuo MH, Sun T, Jiang M, Clinical observation on the combined treatment of 57 cases of non-small cell lung cancer using argon-helium cryosurgery and Chinese herbal medicine, Chinese journal of integrative medicine, 2007, 13(3), 224-7.
38. Wang F, Gao Y, Gao L, Xing T, Study on the electrochemical behavior of the anticancer herbal drug berberine and its analytical application, Journal of the Chinese Chemical Society, 2011, 58(4), 450-6.
39. Patil JB, Kim J, Jayaprakasha GK, Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway, European journal of pharmacology, 2010, 645(1), 70-8.
40. Kokate CK., purohit AP, Gokhale SB, Pharmacognosy. 39th ed. Maharashtra: Nirali prakashan; 2007. P. 215, 221, 349, 385, 395, 360, 381, 415, 424, 450, 484, 511, 515, 534.
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Zishan M, Saidurrahman S, Anayatullah A, Azeemuddin A, Ahmad Z, Hussain M. NATURAL PRODUCTS USED AS ANTI-CANCER AGENTS. JDDT [Internet]. 14May2017 [cited 15May2024];7(3):11-8. Available from: https://jddtonline.info/index.php/jddt/article/view/1443
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