DRUG UTILIZATION PATTERN AND ADVERSE DRUG REACTION MONITORING IN URINARY TRACT INFECTION PATIENTS IN A TERTIARY CARE HOSPITAL

  • Eima Fatima Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India
  • Arifa Anwar Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research and HAHC Hospital, Jamia Hamdard, New Delhi-110062, India
  • Mridu Dudeja Department of Microbiology, Hamdard Institute of Medical Sciences and Research and HAHC Hospital, Jamia Hamdard, New Delhi-110062, India
  • Mohd. Akhtar Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India
  • Abul Kalam Najmi Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

Abstract

Background: Urinary tract infection is a key public health issue causing morbidity, especially in women population. This problem is further aggravated in pregnant women. Aims:This study was designed to evaluate the drug prescribing behaviour and adverse drug reaction monitoring in urinary tract infection patients in a tertiary care hospital. Materials and Methods:The present study was prospective, observational and carried out for four months, and done to assess the drug utilization pattern, adverse drug reactions (ADRs) and to identify the bacterial pathogens associated with UTI and their susceptibility to antibiotics.Results:A total of 327 female patients were evaluated, out of which 248 (75.84%) cases were symptomatic. The study reflected maximum of 50.46% UTI in the age group 21-30 years. Pathogens isolated after a urine culture were of both Gram positive 131 (40.07%) and Gram negative 196 (59.93%) type. The maximum incidence (45.80 %) occurred in last trimester of pregnancy. The most frequently prescribed antibiotic to the pregnant patients in our study was Nitrofurantoin, whereas Amoxicillin with Clavulanic acid was most frequently used in non pregnant cases. Most common ADRs reported with almost all classes of antibiotics was nausea and vomiting followed by vaginal irritation, skin rash and photosensitivity.Conclusion:To ensure appropriate therapy, current knowledge of the pathogenic organism and their antibiotic susceptibility pattern is mandatory, especially in cases of UTI with pregnancy.

Keywords: Drug utilization pattern,Adverse Drug Reactions, Urinary Tract Infection, Renal Pharmacology

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Author Biographies

Eima Fatima, Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

 

Arifa Anwar, Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research and HAHC Hospital, Jamia Hamdard, New Delhi-110062, India

Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research and HAHC Hospital, Jamia Hamdard, New Delhi-110062, India

Mridu Dudeja, Department of Microbiology, Hamdard Institute of Medical Sciences and Research and HAHC Hospital, Jamia Hamdard, New Delhi-110062, India
Department of Microbiology, Hamdard Institute of Medical Sciences and Research and HAHC Hospital, Jamia Hamdard, New Delhi-110062, India
Mohd. Akhtar, Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

Abul Kalam Najmi, Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

Department of Pharmacology, Faculty of Pharmacy,Jamia Hamdard, New Delhi-110062, India

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1.
Fatima E, Anwar A, Dudeja M, Akhtar M, Najmi A. DRUG UTILIZATION PATTERN AND ADVERSE DRUG REACTION MONITORING IN URINARY TRACT INFECTION PATIENTS IN A TERTIARY CARE HOSPITAL. JDDT [Internet]. 15Nov.2015 [cited 30Mar.2020];5(6):23-0. Available from: http://jddtonline.info/index.php/jddt/article/view/1103