DESIGN AND IN VITRO EVALUATION OF FAST DISSOLVING FILMS CONTAINING HP ß CD INCLUSION COMPLEXES OF LAMOTRIGINE

  • H Doddayya Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
  • Shrishailgouda S Patil Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
  • G Ramya Sree Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
  • H Waseem Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
  • RH Udupi Department of Pharmaceutical Chemistry, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka

Abstract

Objectives: The objectives of the present study is to design and evaluate fast dissolving films of lamotrigine using HP ß CD inclusion complexes with an aim to achieve rapid drug release thereby controlling the seizures in the shortest possible time.

Design: Inclusion complexes of lamotrigine were prepared with hydroxypropyl β cyclodextrin (HP β CD) employing different methods to improve the solubility and mask the bitter taste of the drug. Fast dissolving films were prepared by incorporating the developed inclusion complexes and using hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) as film forming agents and other suitable excipients by solvent casting method.

Results: Inclusion complexes prepared by ultrasonication method resulted in better solubility and dissolution rate compared to other methods studied. The fast dissolving films prepared using inclusion complexes were found to be transparent and smooth in texture. The thickness, drug content, % moisture absorption and moisture loss, folding endurance and weight variation was found to be uniform. In vitro release profiles were inversely proportional to the polymer and directly proportional to superdisintegrant and plasticizer concentration. Optimized formulations (F8 and F12) were subjected for fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) which revealed the absence of any chemical interactions between the excipients of the formulation. The formulations were found to be stable without any significant changes during the stability studies carried out as per the ICH guidelines.

Conclusion: The study revealed the successful development of fast dissolving films of lamotrigine with promising results thereby suggesting the possible use of the developed films in the rapid management of epileptic seizures.

Keywords: Fast dissolving films; epilepsy; lamotrigine; inclusion complex; HPMC; PVA; physico-chemical characterization.

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Author Biographies

H Doddayya, Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
Shrishailgouda S Patil, Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
G Ramya Sree, Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
H Waseem, Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka
Department of Pharmaceutics, N.E.T Pharmacy College, Navodaya Nagar,
Raichur, Karnataka
RH Udupi, Department of Pharmaceutical Chemistry, N.E.T Pharmacy College, Navodaya Nagar, Raichur, Karnataka

Department of Pharmaceutical Chemistry, N.E.T Pharmacy College, Navodaya Nagar,   
Raichur, Karnataka

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1.
Doddayya H, Patil S, Ramya Sree G, Waseem H, Udupi R. DESIGN AND IN VITRO EVALUATION OF FAST DISSOLVING FILMS CONTAINING HP ß CD INCLUSION COMPLEXES OF LAMOTRIGINE. JDDT [Internet]. 15Nov.2014 [cited 7Jul.2020];4(6):99-06. Available from: http://jddtonline.info/index.php/jddt/article/view/1004