TY - JOUR AU - Farhani Samat AU - Nurul Baharum AU - Nor Muzaid AU - Sharifah Syed Ghazali AU - Sharmilee Ramanathan AU - Nuraini Dolbasir AU - Noor Rafizah Aziz PY - 2021/11/15 Y2 - 2024/03/29 TI - Retrospective Audit on Cloxacillin Prescription in Primary Health Care Facilities in Kuala Selangor, Malaysia JF - Journal of Drug Delivery and Therapeutics JA - JDDT VL - 11 IS - 6 SE - Research DO - 10.22270/jddt.v11i6.5110 UR - https://jddtonline.info/index.php/jddt/article/view/5110 AB - Introduction: Cloxacillin is the second most prescribed antibiotic for skin and soft tissue infection in Malaysia. A similar pattern was seen in Kuala Selangor, in which our district demonstrated that the Defined Daily Dose (DDD) of Cloxacillin is high (3.0-8.7) compared to the recommended value from World Health Organization (WHO). However, resistant patterns for Cloxacillin are alarming. This study focuses on appropriate use of Cloxacillin to prevent further antimicrobial resistance. Methodology: This is a retrospective cross-sectional audit, conducted in seven public health clinics in Kuala Selangor district from January 2020 to March 2020. All Cloxacillin prescriptions within this duration were selected. Audit format was adapted from the antimicrobial stewardship protocol (AMS). Appropriate Cloxacillin use is based on accuracy of diagnosis, indication of antibiotic, correct usage (pharmacological name, dose, frequency and duration). Results: A total of 259 prescriptions were collected. Majority were for age 40 years old, 48.6% (n=126) and male, 63.7% (n=165). Cloxacillin was prescribed most for infection of the skin and subcutaneous tissue 64.1% (n=166). Diagnosis was accurate in 63.7% (n=165). Those accurate diagnosis, had correct indication 79.4% (131/165); correct usage 51.5% (85/165); correct name 69.7% (115/165); correct frequency 55.2% (91/165); correct dose 55.8% (92/165), and correct duration 47.3% (78/165). Appropriate Cloxacillin use was 41.8% (69/165). Conclusion: Measures to improve appropriate Cloxacillin use and adherence to the National Antibiotic Guideline (NAG) and Antimicrobial Stewardship (AMS) protocol is crucial.Keywords: Cloxacillin, Skin and soft tissue infection, Malaysia, antimicrobial resistance ER -