A Review on Floating Tablet
Abstract
Floating drug delivery systems (FDDS) are designed with a lower bulk density than gastric fluids, enabling them to remain buoyant in the stomach for extended periods without affecting the gastric emptying rate. While floating on the stomach's contents, these systems release medication in a controlled and sustained manner. Once the drug is fully released, the system disintegrates or is emptied from the stomach. This mechanism increases the Gastric Residence Time (GRT), leading to improved control over fluctuations in plasma drug concentration. To achieve this, FDDS must possess sufficient structural integrity to form a cohesive gel barrier and release the drug gradually while maintaining a density lower than that of gastric fluids. These systems are typically developed using effervescent and non-effervescent approaches that rely on buoyancy mechanisms. Such methodologies are particularly beneficial for delivering drugs with a narrow therapeutic window. Our review aims to provide detailed insights into the pharmaceutical principles guiding the design, classification, and preparation of FDDS. It also explores factors influencing their performance, their advantages, applications, limitations, and potential future advancements in this innovative drug delivery system.
Keywords: Floating drug delivery system, Polymer, Gastroretentive system, Prolonged Gastric Retention, Controlled Drug Release.
Keywords:
Floating drug delivery system, Polymer, Gastroretentive system, Prolonged Gastric Retention, Controlled Drug ReleaseDOI
https://doi.org/10.22270/jddt.v15i2.7015References
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