Biological Activities and Mechanisms of Actions of Bioactive Compounds (BACS) Identified in Pure and Ternary Blends of Cocoyam, Soya Bean and Bambara Groundnut Flour Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique: A Review

Authors

  • Henry Chukwuemeka Uro-Chukwu Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria https://orcid.org/0000-0001-7561-4160
  • Franklyn Chidiebere Uro-Chukwu Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria
  • Frances Chidinma Uro-Chukwu Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria

Abstract

Background: functional foods contain bioactive compounds (BACS) and can be sourced from both animals and plants like cocoyam (CY), soya bean (SB) and bambara groundnut (BGN). previous studies have reported various bacs in each of these plants but literature is scanty on the types and amount, of bacs in such flour blends and formulations. when in combinations as blend, anti-oxidant, interactions occur, resulting in either potentiation, additive, synergistic or antagonistic effect, depending on several various variables. their in-vivo bioactivities which are due to various structural features of the BACS, can be antioxidant, anti-inflammatory, hypocholestrolaemic, antimicrobial and anti-diabetic activities. in this review the various bacs identified by gas chromotagraphy (GC)-mass spectrometry (MS) technique in the various formulations of CY-SB-BGN flour blends were researched for their biological activities and reported mechanisms of actions.

Methodology: a google search of a study on bacs identified using gc-ms in cy-sb-bgn flour blend was conducted and one paper was identified. the bacs reported in the study was noted and literature search of the various biological activities of such compounds and their mechanisms of actions were conducted. the results were documented and discussed.

Results and Discussion: the study revealed that thiadiazole, stilbene, aziridine, thiourea, amphetamine/phenylethylene, artemisinin, monoterpenoids, naphthalenes, i,4-diazpanes, phenols and flavanoids were the identified bacs in cy-sb-bgn flour blend formulations with both the pure and ternary blends showing different family classifications of compounds and different types of compounds in one family class. the biological activities and mechanisms of actions included antimicrobial, antioxidant, antiinflammatory and antidiabetic activities with reported mechanisms of actions for each of these invivo activities.

Conclusion: there are bacs in cy-sb-bgn formulations which are reported from studies to possess anti-microbial, anti-inflammatory, anti-oxidant and anti-diabetic properties invivo, with very established mechanisms of actions, making the use of such plant foods in disease management scientific, hence the recommendation of such plant foods use as adjunct in chronic disease management. 

Keywords: Bioactive compounds, Plant foods, Cocoyam, Soya Bean, Bambara Groundnut

Keywords:

Bioactive compounds, mechanisms, plant foods

DOI

https://doi.org/10.22270/jddt.v15i1.6973

Author Biographies

Henry Chukwuemeka Uro-Chukwu , Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria

Department of Medical Biochemistry, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria

 

Franklyn Chidiebere Uro-Chukwu , Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria

Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria

Frances Chidinma Uro-Chukwu, Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria

Institute of Nutrition, Nutraceuticals & Public Health Research & Development, Nigeria

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Uro-Chukwu HC, Uro-Chukwu FC, Uro-Chukwu FC. Biological Activities and Mechanisms of Actions of Bioactive Compounds (BACS) Identified in Pure and Ternary Blends of Cocoyam, Soya Bean and Bambara Groundnut Flour Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique: A Review. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 7];15(1):177-86. Available from: https://jddtonline.info/index.php/jddt/article/view/6973

How to Cite

1.
Uro-Chukwu HC, Uro-Chukwu FC, Uro-Chukwu FC. Biological Activities and Mechanisms of Actions of Bioactive Compounds (BACS) Identified in Pure and Ternary Blends of Cocoyam, Soya Bean and Bambara Groundnut Flour Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique: A Review. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 7];15(1):177-86. Available from: https://jddtonline.info/index.php/jddt/article/view/6973