A Novel Treatment for Scabies with Herbal Formulation: A Clinical Safety Assessment Study

Authors

  • Arjumand Shah Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India
  • Arif Habib Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India
  • Arsheed Iqbal Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India
  • Huma Rafiq Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India
  • Irfat Ara Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India
  • Nighat Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India
  • Bashrat Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Abstract

Introduction: Scabies, known as Jarb in Unani medicine, is a parasitic infection caused by the mite Sarcoptes scabiei var. Hominis. It is characterized by intense itching, particularly noted by patients at night. In India, this disease affects over three million people, manifesting as papular or vesicular eruptions accompanied by pruritus. Unani physicians have developed comprehensive treatments for scabies, considering its causative factors and various types.

Methods: This study was conducted as an open-label, single-arm clinical trial involving 75 patients diagnosed with scabies with male female ration of 1:2.7. The primary objective was to assess the efficacy and safety of a compound Unani formulation. The test group received a Compound Unani formulation Irtifal Shahtra (Fumaria indica Pugsley) at a dose of 5 grams twice daily, Marham Kharish Jadeed (Lawsonia inermis) for topical application twice daily, and Aab-e-Barg-e-Neem (a decoction of Neem leaves) for washing the affected areas before applying Marham twice daily, for a duration of 15 days. Both subjective and objective parameters were evaluated before and after the treatment period.

Results: In this study, 94% patients reported a significant reduction in itching after using unani formulation for Scabies. Only 5% patients had mild itching at the end of the study. Regarding cure of the lesions, the reduction in mean values from before to after treatment indicates an improvement in skin lesions. P-value less than 0.05 indicate that the results are statistically significant. Objective parameters such as the skin scraping test, demonstrated a significant reduction (p<0.001). Importantly, no adverse effects were observed with the treatment regimen, further highlighting its effectiveness in alleviating scabies symptoms.

Conclusion: This study highlights the safe and effective utilization of Unani formulations in treating one of the most distressing skin disease scabies, without any adverse effects.

Keywords: Scabies, Jarb, Itrifal shahtra, Barg neem, Marham Kharish Jadeed, Classical Pharmacopoeial formulations. 

Keywords:

Scabies, Jarb, Itrifal shahtra, Barg neem, Marham Kharish Jadeed, Classical Pharmacopoeial formulations

DOI

https://doi.org/10.22270/jddt.v15i1.6953

Author Biographies

Arjumand Shah , Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Arif Habib, Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Arsheed Iqbal, Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Huma Rafiq, Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Irfat Ara, Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Nighat, Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Bashrat, Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

Regional Research Institute of Unani Medicine, Deptt. of AYUSH, Naseembagh campus, University of Kashmir, India

References

1. Ali M S, Alam M, Jamal A. Clinical evaluation of the efficacy of the poly herbal unani formulation in scabies. India journal of traditional knowledge vol 5(2), 2006, PP 222-223

2. Ali Mehtab S,Alam m,&Jamal M,et al.Clinical Evaluation of the efficacy of polyherbal unani formulation in scabies. Indian journal of traditional knowledge 2006 Vol.5(2), pp 220-223.

3. Azdajic M.D, Beslic I, Gasic A et al. Increased Scabies incidence at the beginning of 21st century. What do reports from Europe and world show. Life 2022, 12 (10) 2022. https://doi.org/10.3390/life12101598 PMid:36295033 PMCid:PMC9604680

4. Arzani MA (1924): Tibbe-e-Akbar.J.S.Sardar Sant Singh and sons,Lahore,vol-2,PP273-274.

5. Dagne H. Dessie A. Destaw Prevalence and associated factors of scabies among school children in District northwest

6. Hossain ASMT, Handbook of dermatology and venereology, AITBS publishes and distributors medical publishers, 2006 pp.

7. Ibni Sina, Alkanoon - fit -tib (Tibbi-e- islami ka encyclopedia) vol 2( translated by Syed Hussain Kantoori, Lahor) 1912, 361-364

8. Kouotou EA, Defo D, Sieleunou I, Ndikontar Kwinji R, Mukwelle K, Essama J, et al. La Gale Humaine : Profil Sociodémographique, Distribution Lésionnelle et Types de Lésions. Health Sci Dis. 2013;14 (3). [Google Scholar]

9. Mastan A, Abid M, Anjum A et al. blood purifier: Unani concept of treatment in Unani system of medicine for various disorders. International journal of biological sciences. 6(2) : 105-110

10. Matthewman J, Manego R. Z,et al. A randomized controlled trial comparing the effectiveness of individual verses household treatment for scabies in Lambarene Gabon.PLOS Negl Trop Dis 14 (6).e 0008423 https://doi.org/10.1371/journal.pntd.0008423 PMid:32589632 PMCid:PMC7347237

11. Mohammad A, Alzohairy. Therapeutics role of Azadirachta indica (neem) and their active constituents in diseases prevention and treatment evidence based complementary and alternative medicine 2016, 1-11. https://doi.org/10.1155/2016/7382506 PMid:27034694 PMCid:PMC4791507

12. Mohashine BM, Michiko N, Seishi M, Tsutomu S. antibacterial effects of crude Azadirachta indiac neem bark extract on streptococcus sorbrinus, paediatric dental journal. 9097; 7(1) :61-64.

13. Nafees A, Shar-e- Asbab, translated by Kabir ud-din M (Islamic bazar Nool-ul-Moor, Hyderabad), 1950;3:1211-1213

14. Nair PA, Vora R V, Et al.A study of clinical profile and quality of life in patients with scabies at arural tertiary care centre.Journal of clinical and diagnostic research .10(10) WC 01-WC 05.

15. Oktarina C,Surya D et al.Association between nutritional status and scabies infestation in a boarding school in Indonesia:a cross sectional study .Iranian Journa of dermatology 2021:24:280-285.

16. Rahman J, Farooqi A.H, Sultana A et al. Clinical efficacy of a herbo-mineral formulation in scabies: an open -label randomized controlled study. Oriental pharmacy and experimental med.

17. Sharma K Joshi N, Goyal C. critical review of Ayurvedic Varnya herbes and their tyrocinase inhibition effect, ancient science of life. 2015; 35(1): 18-25 https://doi.org/10.4103/0257-7941.165627 PMid:26600663 PMCid:PMC4623628

18. Tabri, Abul hasan Ali (780-850 AD), Al-Moalijatull Buqratiya,Vol II,(urdu Translation done by Central Council for Research in Unani Medicine),1997,164icine.vol-15:173-181:2015.

19. Nasir A, Fatma G, Siddiqui ma. concept and management of scabies (jarb) in unani system of medicine.

20. Marina A, Menaldi SL, Novianto E, Widaty S. Efficacy of 5% permethrin-2% fusidic acid cream compared to 5% permethrin-placebo in the treatment of impetiginized scabies. The Journal of Infection in Developing Countries. 2022 Jun 30;16(06):1045-54. https://doi.org/10.3855/jidc.15205 PMid:35797300

21. Jowkar FA, Jamshidzadeh A, Yazdi AM, Pasalar M. The effects of fumaria parviflora L extract on chronic hand eczema: a randomized double-blind placebo controlled clinical trial. Iranian Red Crescent Medical Journal. 2011 Nov;13(11):824.

22. Shivaprasad HN, Kharya MD, Rana AC, Mohan S. Preliminary Immunomodulatory Activities of the Aqueous Extract of Terminalia chebula. Pharmaceutical Biology. 2006 Jan 1; 44(1):32-4. https://doi.org/10.1080/13880200500530542

23. Abood WN. Immunomodulatory and anti-inflammatory effects of bioactive compounds of Cassia angustifolia Vahl. leaf extract. Plant Science Today. 2024 Apr 14;11(2). https://doi.org/10.14719/pst.3159

24. Ram MS, Neetu D, Yogesh B, Anju B, Dipti P, Pauline T, Sharma SK, Sarada SK, Ilavazhagan G, Kumar D, Selvamurthy W. Cyto-protective and immunomodulating properties of Amla (Emblica officinalis) on lymphocytes: an in-vitro study. Journal of ethnopharmacology. 2002 Jun 1;81(1):5-10. https://doi.org/10.1016/S0378-8741(01)00421-4 PMid:12020921

25. Arokiaraj MC, Menesson E. Novel anti-inflammatory and immunomodulation effects of Rose on the endothelium in normal and hypoxic invitro conditions. Angiologia e Cirurgia Vascular. 2019;15(4):238-48.

Published

15-01-2025
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How to Cite

1.
Shah A, Habib A, Iqbal A, Rafiq H, Ara I, Nighat D, et al. A Novel Treatment for Scabies with Herbal Formulation: A Clinical Safety Assessment Study. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 16];15(1):59-66. Available from: https://jddtonline.info/index.php/jddt/article/view/6953

How to Cite

1.
Shah A, Habib A, Iqbal A, Rafiq H, Ara I, Nighat D, et al. A Novel Treatment for Scabies with Herbal Formulation: A Clinical Safety Assessment Study. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 16];15(1):59-66. Available from: https://jddtonline.info/index.php/jddt/article/view/6953

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