Formulation And Evaluation of Betulinic Acid Loaded Transdermal Patches
Abstract
Many disorders, including cardiovascular diseases, Parkinson's disease, Alzheimer's disease, fungal diseases, depression, anxiety, and Attention Deficit Hyperactivity Disorder (ADHD), skin cancer, female sexual dysfunction, post-menopausal bone loss, and urine incontinence, can now be treated with transdermal delivery systems. A naturally occurring pentacyclic triterpenoid, betulinic acid possesses antiretroviral, antimalarial, and anti-inflammatory qualities. More recently, it has been shown to have anticancer potential through topoisomerase inhibition. The goal of the current study was to create transdermal patches with a controlled release action that included several polymers and an anti-inflammatory medication, such as betulinic acid..The solvent evaporation approach was successfully used to create the betulinic acid transdermal patch. Betulinic acid transdermal patches for transdermal medication administration were assessed. A calibration curve was acquired, a transdermal film was made, and the drug's bioavailability constraints were addressed.
Keywords: Controlled DDS, Transdermal DDS, Betulinic acid, Transdermal Patch, solvent evaporation method.
Keywords:
Controlled DDS, Transdermal DDS, Betulinic acid, Transdermal Patch, Solvent evaporation methodDOI
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Copyright (c) 2025 Manmeet Kumar , Prashanta Bose , Amar Pal Singh , Ajeet Pal Singh

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