Formulation And Evaluation of Betulinic Acid Loaded Transdermal Patches

Authors

  • Harmanjit Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
  • Prashanta Bose Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
  • Amar Pal Singh Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0000-0003-0027-2869
  • Ajeet Pal Singh Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India. https://orcid.org/0000-0002-1212-5770

Abstract

Many disorders, including cardiovascular diseases, Parkinson's disease, Alzheimer's disease, fungal diseases, depression, anxiety, and Attention Deficit Hyperactivity Disorder (ADHD), skin cancer, female sexual dysfunction, post-menopausal bone loss, and urine incontinence, can now be treated with transdermal delivery systems. A naturally occurring pentacyclic triterpenoid, betulinic acid possesses antiretroviral, antimalarial, and anti-inflammatory qualities. More recently, it has been shown to have anticancer potential through topoisomerase inhibition. The goal of the current study was to create transdermal patches with a controlled release action that included several polymers and an anti-inflammatory medication, such as betulinic acid..The solvent evaporation approach was successfully used to create the betulinic acid transdermal patch. Betulinic acid transdermal patches for transdermal medication administration were assessed. A calibration curve was acquired, a transdermal film was made, and the drug's bioavailability constraints were addressed.

 Keywords: Controlled DDS, Transdermal DDS, Betulinic acid, Transdermal Patch, solvent evaporation method.

Keywords:

Controlled DDS, Transdermal DDS, Betulinic acid, Transdermal Patch, Solvent evaporation method

DOI

https://doi.org/10.22270/jddt.v15i1.6951

Author Biographies

Harmanjit Singh, Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Prashanta Bose , Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Amar Pal Singh , Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Ajeet Pal Singh , Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

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Published

15-01-2025
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How to Cite

1.
Singh H, Bose P, Singh AP, Singh AP. Formulation And Evaluation of Betulinic Acid Loaded Transdermal Patches. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 16];15(1):52-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6951

How to Cite

1.
Singh H, Bose P, Singh AP, Singh AP. Formulation And Evaluation of Betulinic Acid Loaded Transdermal Patches. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 16];15(1):52-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6951

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