Formulation and Evaluation of Liposomal Cream Containing Tolnaftate

Authors

  • Darshini D* Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka
  • Likhita B Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka
  • Mohitha Y B Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka
  • Aruna Kumari V Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka
  • M Hema Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka
  • Ahasanuzzaman Assistant Professor, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Abstract

The current study’s objective was to formulate and evaluate a liposomal cream containing tolnaftate in order to improve the drug’s bioavailability. Tolnaftate is a drug having low permeability which results in decreased drug absorption and so is the bioavailability. To overcome these problems tolnaftate is incorporated in liposomes. Liposome vesicular drug delivery system was preferred due to its greater solubility, permeability and bioavailability. It carries a substantial amount of drug which increased the drug’s penetration. The liposomes were prepared using a variety of phospholipids, specifically soy lecithin and egg phosphatidylcholine in varying ratios. Liposomes were prepared by ethanol injection method and evaluated for morphology, percentage practical yield, percentage entrapment efficiency, drug content and in-vitro drug release study. The formulation with the best result according to the evaluation parameters was F2 with greater percentage drug entrapment, drug content and in-vitro drug release was considered to be optimized formulation and this F2 formulation was further evaluated by SEM, DSC and XRD. Liposomal cream was formulated using the optimized formulation. Spreadability, Viscocity, pH measurement and in-vitro drug release were evaluated for liposomal cream. Formulation F2 and optimized liposomal cream formulation showed in-vitro drug release of 92.44% and 77.48% respectively at the end of 8th hour.

Keywords: Tolnaftate, liposomes, SEM, DSC, XRD

Keywords:

Tolnaftate, liposomes, SEM, DSC, XRD

DOI

https://doi.org/10.22270/jddt.v15i1.6944

Author Biographies

Darshini D*, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Likhita B, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Mohitha Y B, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Aruna Kumari V, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

M Hema, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Ahasanuzzaman, Assistant Professor, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Assistant Professor, Department of Pharmaceutics, Spurthy College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

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Published

15-01-2025
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How to Cite

1.
Darshini D, Likhita B, Mohitha YB, Aruna Kumari V, Hema M, Ahasanuzzaman D. Formulation and Evaluation of Liposomal Cream Containing Tolnaftate. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 16];15(1):13-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6944

How to Cite

1.
Darshini D, Likhita B, Mohitha YB, Aruna Kumari V, Hema M, Ahasanuzzaman D. Formulation and Evaluation of Liposomal Cream Containing Tolnaftate. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 16];15(1):13-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6944