Composition and Drug Release Characteristics of Bi-layered and Multi-layered Tablets: A Comprehensive Review
Abstract
Multilayer and Bilayer tablets are winning popularity over single-layer tablets because of their controlled release advantages. Since each layer of API must be compatible with the others and with excipients to extend the effects of the medication or drugs and improve patient compliance, technology for creating multilayers and bilayers is less widespread than that for single-layer tablets. Hydrophilic polymers are more frequently employed in the formulation of biliary and multilayer tablets as both medication carriers and release barriers. But the ratio of using polymer is different from each other in the drug barrier layer and carrier layer that can make alteration by a researcher to develop a difference in the release rate of different APIs in a single unit of the tablet. With a larger surface area and a faster rate of drug release over time, multilayer and biliary tablets can help mitigate the non-linearity and drug interactions that arise with diffusion-controlled matrix devices. This review article covers the different techniques used to create biliary and multilayered tablets as well as the challenges associated with their formulation.
Keywords: Multi-layer tablets, Bi-layer tablets, Drug release, Tablet manufacturing
Keywords:
Multi-layer tablets, Bi-layer tablets, Drug release, Tablet manufacturingDOI
https://doi.org/10.22270/jddt.v15i1.6936References
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