Combination Therapy of SGLT 2 Inhibitors and GLP 1 Receptor Agonists for Glycaemic Management through Weight Reduction

Authors

  • Vinod Kumar Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India. https://orcid.org/0009-0000-7299-7688
  • Amulya V B Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India. https://orcid.org/0009-0009-9956-2380
  • Manjari Sharma Assistant Professor, Institution of Pharmaceutical Science, PES University, Bangalore, Karnataka, India.
  • Saikrupa B V Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India. https://orcid.org/0000-0002-3770-8358

Abstract

A great deal of anti-diabetic drugs leads to weight gain, which could contribute to obesity and possibly both diabetes and obesity. Glucose-lowering medications that contain sodium-glucose co-transporter 2 (SGLT2) inhibitors work by preventing the kidneys from reabsorbing glucose and sodium, which causes glycosuria and lowers plasma glucose levels. Consequently, its effects include decreases in HbA1c, blood glucose levels, and blood pressure along with decline in body weight and adiposity. Consistently, people on medications that inhibit SGLT2 tend to lose weight, but this weight loss is only modest since opposing regulatory processes work to keep the body's weight constant. This has driven researchers to investigate the use of SGLT2 inhibitors in combination with other drugs that work by reducing appetite, such as glucagon-like peptide 1 receptor agonists (GLP1RAs). In a retrospective study at the Wolver Hampton Diabetes Centre, researchers evaluated the effectiveness of combination therapy using GLP-1 agonists and SGLT-2 inhibitors in the management of diabetes and obesity. Patients on the combined regimen showed statistically significant improvements in clinical measures like body weight reduction, glycated hemoglobin (HbA1c) reduction, lower BMI, and reduced insulin dose. Such combinations, which include SGLT2 inhibitors, are intriguing because of the bodyweight effects and the indications of protection of cardiovascular and renal problems. These results imply that combination therapy using GLP-1 agonists and SGLT-2 inhibitors offers individuals with diabetes and obesity a promising treatment choice

Keywords:  Diabetes Mellitus, obesity, SGLT 2 inhibitors, GLP 1 receptor agonist.

Keywords:

Diabetes Mellitus, obesity, SGLT 2 inhibitors, GLP 1 receptor agonist

DOI

https://doi.org/10.22270/jddt.v15i1.6914

Author Biographies

Vinod Kumar , Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India.

Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India.

Amulya V B , Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India.

Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India.

Manjari Sharma , Assistant Professor, Institution of Pharmaceutical Science, PES University, Bangalore, Karnataka, India.

Assistant Professor, Institution of Pharmaceutical Science, PES University, Bangalore, Karnataka, India. 

Saikrupa B V , Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India.

Pharm D, Institution of Pharmaceutical Science (Formerly PES College of Pharmacy), Bangalore, Karnataka, India.

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Published

15-01-2025
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How to Cite

1.
Kumar V, Amulya VB, Sharma M, Saikrupa BV. Combination Therapy of SGLT 2 Inhibitors and GLP 1 Receptor Agonists for Glycaemic Management through Weight Reduction. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 7];15(1):142-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6914

How to Cite

1.
Kumar V, Amulya VB, Sharma M, Saikrupa BV. Combination Therapy of SGLT 2 Inhibitors and GLP 1 Receptor Agonists for Glycaemic Management through Weight Reduction. J. Drug Delivery Ther. [Internet]. 2025 Jan. 15 [cited 2025 Feb. 7];15(1):142-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6914