Formulation, Development and Evaluation of Pulsatile Tablets of Etoricoxib

Authors

  • Rahul S. Radke Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India
  • Bharat B. Dhore Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India
  • Ramesh R. Pagore Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India
  • Kailash R. Biyani Anuradha College of Pharmacy, Cikhli Dist. Buldhana, MS, India

Abstract

Aim: This research aimed to develop a pulsatile drug delivery system (PDDS) for etoricoxib, selective COX-2 inhibitor analgesic, to address the limitations of conventional formulations by releasing the drug at specific intervals aligned with the circadian rhythm of pain.

Method: Core tablets containing Etoricoxib were prepared by direct compression with varied concentrations of croscarmellose sodium as a superdisintegrant. The optimized core tablets were coated using hydrophilic (HPMC K4M) and hydrophobic (ethyl cellulose) polymers in different ratios to create press-coated pulsatile tablets with varying lag times. Physical properties hardness, thickness, friability, and disintegration, drug content uniformity, and in vitro release were evaluated.

Results: The core tablets exhibited rapid drug release, with batch C3 showing 98.61% release within 60 minutes. Press-coated formulations with different polymer ratios exhibited varying lag times, with batch F3 achieving the optimal balance—providing a 4-hour lag time and 96.6% drug release over 8 hours. Stability studies confirmed the physical and chemical stability of the optimized formulation (F3) over 6 months under accelerated conditions.

Conclusion: The developed press-coated pulsatile tablets of etoricoxib successfully achieved a controlled lag time and sustained drug release profile, making them suitable for chronopharmacological management of pain.

Keywords: Etoricoxib, Pulsatile Drug Delivery System, Chronopharmacology, Press-Coated Tablets. etc

Keywords:

Etoricoxib, Pulsatile Drug Delivery System, Chronopharmacology, Press-Coated Tablets

DOI

https://doi.org/10.22270/jddt.v14i11.6890

Author Biographies

Rahul S. Radke, Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India

Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India

Bharat B. Dhore , Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India

Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India

Ramesh R. Pagore , Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India

Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldhana, MS, India

Kailash R. Biyani , Anuradha College of Pharmacy, Cikhli Dist. Buldhana, MS, India

Anuradha College of Pharmacy, Cikhli Dist. Buldhana, MS, India

References

1. Gandhi BR, Mundada AS, Gandhi PP. Chronopharmaceutics: As a clinically relevant drug delivery system. Drug Deliv. 2011;18(1):1–18. https://doi.org/10.3109/10717544.2010.509358

2. Maroni A, Zema L, Del Curto MD, Loreti G, Gazzaniga A. Oral pulsatile delivery: Rationale and chronopharmaceutical formulations. Int J Pharm. 2010;398:1–8. https://doi.org/10.1016/j.ijpharm.2010.07.026

3. Smolensky MH, Peppas NA. Chronobiology, drug delivery, and chronotherapeutics. Adv Drug Deliv Rev. 2007;59:828–51. https://doi.org/10.1016/j.addr.2007.07.001

4. Venkataswamy R, Nallaguntla L. Review article on pulsatile drug delivery system. Asian J Pharm Clin Res. 2021;14(6):48–59. https://doi.org/10.22159/ajpcr.2021.v14i6.41476

5. Jagdale SC, Suryawanshi VM, Pandya SV, Kuchekar BS, Chabukswar AR. Development of press-coated, floating-pulsatile drug delivery of lisinopril. Sci Pharm. 2014;82(2):423–40. https://doi.org/10.3797/scipharm.1301-27

6. Rane AB, Gattani SG, Kadam VD, Tekade AR. Formulation and evaluation of press-coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers. Chem Pharm Bull. 2009;57(11):1213–7. https://doi.org/10.1248/cpb.57.1213

7. Rohini RS. Formulation and evaluation of pulsatile drug delivery system of Pregabalin. Pharm Anal Acta. 2016;7:508. https://doi.org/10.4172/2153-2435.1000508

8. Dabhi C, Randale S, Belgamwar V, Gattani S, Tekade A. Predictable pulsatile release of etoricoxib hydrochloride for chronotherapeutics of arthritis. Drug Deliv. 2010;17(5):273–81. https://doi.org/10.3109/10717541003706240

9. Ghimire M, McInnes FJ, Watson DG, Mullen AB, Stevens HN. In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: A pharmacoscintigraphic study in the beagle dog. Eur J Pharm Biopharm. 2007;67:515–23. https://doi.org/10.1016/j.ejpb.2007.03.002

10. Sawale AV, Jajoo VS, Deshmukh AA. Formulation and evaluation of pulsatile drug delivery system for the treatment of arthritic pain. Res J Sci Technol. 2024;16(3):193–2. https://doi.org/10.52711/2349-2988.2024.00029

11. Ashwini MS, Ahmed GM. Design and evaluation of pulsatile drug delivery of losartan potassium. J Pharm Sci. 2013;12(2):119–23. https://doi.org/10.3329/dujps.v12i2.17610

12. Ishrath A, Devadas V, Ahmed MM. Formulation, development, and characterization of Diltiazem Pulsin Cap for pulsatile drug delivery. Pharm Tech Res. 2019;9(5). https://doi.org/10.46624/ajptr.2019.v9.i5.009

13. Saııgalli ME, Maroni A, Busetti C, Zema L, Giordano F, Gazzaniga A. In vitro and in vivo evaluation of oral systems for time and site-specific delivery of drugs (Chronotopic® technology). Boll Chim Farmaceutico. 1999;138:68–73.

Published

15-11-2024
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How to Cite

1.
Radke RS, Dhore BB, Pagore RR, Biyani KR. Formulation, Development and Evaluation of Pulsatile Tablets of Etoricoxib. J. Drug Delivery Ther. [Internet]. 2024 Nov. 15 [cited 2024 Dec. 6];14(11):89-94. Available from: https://jddtonline.info/index.php/jddt/article/view/6890

How to Cite

1.
Radke RS, Dhore BB, Pagore RR, Biyani KR. Formulation, Development and Evaluation of Pulsatile Tablets of Etoricoxib. J. Drug Delivery Ther. [Internet]. 2024 Nov. 15 [cited 2024 Dec. 6];14(11):89-94. Available from: https://jddtonline.info/index.php/jddt/article/view/6890