Histopathological Changes in Ovarian Tissues of Rats Underwent Ovarian Ischemia-Reperfusion Injury
Abstract
This study investigates histopathological changes in ovarian tissues of rats subjected to ischemia-reperfusion (I/R) injury, a condition where restored blood flow causes cellular stress and potential damage. Rats were divided into three groups: control, ischemia, and ischemia-reperfusion. Histological analysis revealed that ischemic ovaries exhibited increased follicular degeneration, atretic follicles, and inflammatory infiltration. The ischemia-reperfusion group showed even more pronounced damage, including disrupted cellular structures and severe vascular congestion. These findings highlight the exacerbated tissue damage caused by reperfusion, underscoring the complex impact of I/R injury on ovarian tissue integrity.
Keywords: ovary, ischemia, reperfusion, histology
Keywords:
ovary, ischemia, reperfusionDOI
https://doi.org/10.22270/jddt.v14i11.6887References
1. Huang, Ci et al. "A review of ovary torsion.Tzu-chi medical journal vol. 29,3 (2017): 143-147. https://doi.org/10.4103/tcmj.tcmj_55_17 PMid:28974907 PMCid:PMC5615993
2. Cass, Darrell L. "Ovarian torsion." Seminars in pediatric surgery vol. 14,2 (2005): 86-92. https://doi.org/10.1053/j.sempedsurg.2005.01.003 PMid:15846564
3. Ashwal, Eran et al. "Presentation, Diagnosis, and Treatment of Ovarian Torsion in Premenarchal Girls." Journal of pediatric and adolescent gynecology vol. 28,6 (2015): 526-9. https://doi.org/10.1016/j.jpag.2015.03.010 PMid:26168769
4. Houry, D, and J T Abbott. "Ovarian torsion: a fifteen-year review." Annals of emergency medicine vol. 38,2 (2001): 156-9. https://doi.org/10.1067/mem.2001.114303 PMid:11468611
5. Novoa, Maria et al. "Ovarian torsion: can we save the ovary?." Archives of gynecology and obstetrics vol. 304,1 (2021): 191-195. https://doi.org/10.1007/s00404-021-06008-8 PMid:33638663
6. Sims, Morgan J et al. "Pediatric Ovarian Torsion: Should You Go With the Flow?." Pediatric emergency care vol. 38,6 (2022): e1332-e1335. https://doi.org/10.1097/PEC.0000000000002679 PMid:35639437
7. Aşır F, Oğlak SC, Ağaçayak E, Alabalık U. Homeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm delivery. Perinatal Journal 2023;31(3):213-218 https://doi.org/10.59215/prn.23.0313006
8. Durgun, C, and F Aşır. "Daidzein alleviated the pathologies in intestinal tissue against ischemia-reperfusion." European review for medical and pharmacological sciences vol. 27,4 (2023): 1487-1493. https://doi.org/10.26355/eurrev_202302_31389
9. Aşır F, Ozgokçe F. Momordica charantia reduced ovarian ischemia-reperfusion injury by suppressing APAF-1 expression. European Review for Medical & Pharmacological Sciences, 2023, 27.6.
10. Asir F , Deveci E, Gökalp E, et al. The Effect of Momordica charantia on Ovarian Ischemia-Reperfusion. Journal of Biosciences and Medicines, 2021, 9.12: 8-14.
11. Aktaş A, et al. Granulocyte colony stimulating factor (GCSF) protected in ovarian tissues against ischemia-reperfusion injury. Journal of Drug Delivery and Therapeutics, 2022, 12.4: 26-30. https://doi.org/10.22270/jddt.v12i4.5538
12. Peker N, Deger U, Aşır F. Investigation of the effects of carvacrol on experimental ischemia/reperfusion model of rat ovaries by immunohistochemistry. Anal Quant Cytopathol Histopathol, 2021, 42.6: 197-204.
13. Hortu I, Ilgen O, Sahin C, Akdemir A, Yigitturk G, Erbas O. Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study. J Obstet Gynaecol. 2020; 40(8): 1148-1154. https://doi.org/10.1080/01443615.2019.1701639 PMid:31955629
14. Melekoglu R, Ciftci O, Eraslan S, Alan S, Basak N. The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries. Biomed Res Int. 2018; 2018(1): 1-7. 96. https://doi.org/10.1155/2018/5421308 PMid:29862276 PMCid:PMC5976983
Published
PDF Downloads: 34
PDF Downloads: 3
How to Cite
Issue
Section
Copyright (c) 2024 Esranur Atiç , Muhyiddin Sancar , Mehmet Uğur Karabat , Şehmus Kaplan , Fırat Aşır, Murat Akkuş
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).