Histopathological Changes in Ovarian Tissues of Rats Underwent Ovarian Ischemia-Reperfusion Injury
Abstract
This study investigates histopathological changes in ovarian tissues of rats subjected to ischemia-reperfusion (I/R) injury, a condition where restored blood flow causes cellular stress and potential damage. Rats were divided into three groups: control, ischemia, and ischemia-reperfusion. Histological analysis revealed that ischemic ovaries exhibited increased follicular degeneration, atretic follicles, and inflammatory infiltration. The ischemia-reperfusion group showed even more pronounced damage, including disrupted cellular structures and severe vascular congestion. These findings highlight the exacerbated tissue damage caused by reperfusion, underscoring the complex impact of I/R injury on ovarian tissue integrity.
Keywords: ovary, ischemia, reperfusion, histology
Keywords:
ovary, ischemia, reperfusionDOI
https://doi.org/10.22270/jddt.v14i11.6887References
1. Huang, Ci et al. "A review of ovary torsion.Tzu-chi medical journal vol. 29,3 (2017): 143-147. https://doi.org/10.4103/tcmj.tcmj_55_17 PMid:28974907 PMCid:PMC5615993
2. Cass, Darrell L. "Ovarian torsion." Seminars in pediatric surgery vol. 14,2 (2005): 86-92. https://doi.org/10.1053/j.sempedsurg.2005.01.003 PMid:15846564
3. Ashwal, Eran et al. "Presentation, Diagnosis, and Treatment of Ovarian Torsion in Premenarchal Girls." Journal of pediatric and adolescent gynecology vol. 28,6 (2015): 526-9. https://doi.org/10.1016/j.jpag.2015.03.010 PMid:26168769
4. Houry, D, and J T Abbott. "Ovarian torsion: a fifteen-year review." Annals of emergency medicine vol. 38,2 (2001): 156-9. https://doi.org/10.1067/mem.2001.114303 PMid:11468611
5. Novoa, Maria et al. "Ovarian torsion: can we save the ovary?." Archives of gynecology and obstetrics vol. 304,1 (2021): 191-195. https://doi.org/10.1007/s00404-021-06008-8 PMid:33638663
6. Sims, Morgan J et al. "Pediatric Ovarian Torsion: Should You Go With the Flow?." Pediatric emergency care vol. 38,6 (2022): e1332-e1335. https://doi.org/10.1097/PEC.0000000000002679 PMid:35639437
7. Aşır F, Oğlak SC, Ağaçayak E, Alabalık U. Homeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm delivery. Perinatal Journal 2023;31(3):213-218 https://doi.org/10.59215/prn.23.0313006
8. Durgun, C, and F Aşır. "Daidzein alleviated the pathologies in intestinal tissue against ischemia-reperfusion." European review for medical and pharmacological sciences vol. 27,4 (2023): 1487-1493. https://doi.org/10.26355/eurrev_202302_31389
9. Aşır F, Ozgokçe F. Momordica charantia reduced ovarian ischemia-reperfusion injury by suppressing APAF-1 expression. European Review for Medical & Pharmacological Sciences, 2023, 27.6.
10. Asir F , Deveci E, Gökalp E, et al. The Effect of Momordica charantia on Ovarian Ischemia-Reperfusion. Journal of Biosciences and Medicines, 2021, 9.12: 8-14.
11. Aktaş A, et al. Granulocyte colony stimulating factor (GCSF) protected in ovarian tissues against ischemia-reperfusion injury. Journal of Drug Delivery and Therapeutics, 2022, 12.4: 26-30. https://doi.org/10.22270/jddt.v12i4.5538
12. Peker N, Deger U, Aşır F. Investigation of the effects of carvacrol on experimental ischemia/reperfusion model of rat ovaries by immunohistochemistry. Anal Quant Cytopathol Histopathol, 2021, 42.6: 197-204.
13. Hortu I, Ilgen O, Sahin C, Akdemir A, Yigitturk G, Erbas O. Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study. J Obstet Gynaecol. 2020; 40(8): 1148-1154. https://doi.org/10.1080/01443615.2019.1701639 PMid:31955629
14. Melekoglu R, Ciftci O, Eraslan S, Alan S, Basak N. The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries. Biomed Res Int. 2018; 2018(1): 1-7. 96. https://doi.org/10.1155/2018/5421308 PMid:29862276 PMCid:PMC5976983
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Copyright (c) 2024 Esranur Atiç , Muhyiddin Sancar , Mehmet Uğur Karabat , Şehmus Kaplan , Fırat Aşır, Murat Akkuş
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