Formulation and Evaluation of Mucoadhesive Buccal Tablets of Carvedilol
Abstract
The aim of the study was to formulate and evaluate the carvedilol buccal tablets using HPMC K4M and xanthan gum as polymer. Buccal tablets of carvedilol were prepared by direct compression technique by using polymer in combination at different concentration. Drug excipient compatibility study indicates that there is no interaction between the excipient and the drug. Total seven batches were prepared and subjected to evaluation parameters. Pre-compression parameters for all batches showed excellent flow propertied of powder bled. Prepared buccal tablets were evaluated for various post compression parameters like hardness, thickness, weight variation, drug content, and friability, % swelling index, muco-adhesive strength and in vitro drug release. The harness of all batches was optimum showed good mechanical strength; thickness of tablets was uniform in all formulations the weight variation test of all the formulation was found to be within the limits of pharmacopoeial standard. % swelling index for all the batch formulation was optimum and seen to increase with increase in polymer concentration. Mucoadhesive strength was also showed acceptable results for all batch formulations which satisfy the need of mucoadhesive tablets. The in vitro dissolution profile of all the formulation showed sustained release of drug, for extended periods of time. The optimized formulation of F4 prepared with was consider as the optimized formulation with respect to drug content, % swelling index, Mucoadhesive strength and in vitro drug release pattern for 8 hrs. Formulation F4 showed highest 98.32±1.55 % drug release at the end of 8 hrs. Optimized formulation F4 was found to be stable during the stability studies for 3 month indicating good stability of the formulation.
Keywords: carvedilol, Mucoadhesive strength, Optimized formulation, buccal tablets.
Keywords:
carvedilol, Mucoadhesive strength, Optimized formulation, buccal tabletsDOI
https://doi.org/10.22270/jddt.v14i11.6876References
1. Shojaei AH, Chang RK, Guo X. Systemic drug delivery via the buccal mucosal route. J. Pharm. Technol. 2001;25(6):70-81.
2. Rojanasakul Y, Wang LY, Bhat M, Glover DD, Malanga CJ, Ma JKH. The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharm. Res. 1992;9:1029-1034. https://doi.org/10.1023/A:1015802427428
3. Tekade B. W., Jadhao U. T., Kale V. S., Thakare V. M., Chaudhari K. P., Patil V. R. Formulation Development and Evaluation of Mucoadhesive Tablet Containing Citrizine Dihydrochloride using Different Mucoadhesive Polymers. Indo American Journal of Pharmaceutical Research. 3(8):6009-6019.
4. Thakare VM, Jadhao UT, Tekade BW, Chaudhari KP, Chaudhari MB. Formulation and characterization of domperidone buccoadhesive tablet. International Journal of Pharmacy. 2014;4(1):55-60.
5. Yashavant A. Chikate, Kundan P. Chaudhari, Umesh T. Jadhao, Vinod M. Thakare, Bharat W. Tekade, Vijay R. Patil., Formulation And In-Vitro Evaluation Of Simvastatin Buccoadhesive Tablets., Asian J.of Pharma. Science & Tech., 2014;4(3); 156-163.
6. Jadhao UT, Sable SD, Dhembre GN, Ingole RD, Rathod SP, Improvement Of Solubility And Dissolution Rate of Carvedilol By Solid Dispersion Technique., EJPMR, 2021;8(4):435-441.
7. Jaiswal SB, Jadhao UT, Ali SA, Dhembre GN, "Formulation and Evaluation Of Carvedilol Nasal Microspheres" ejbps, 2024;11(10(:193-199.
8. Veuillez F, Kalia YN, Jacques Y, Deshusses J, Buri P. Factors and strategies for improving buccal absorption of peptides. Eur. J. Pharm. Biopharm. 2001;51:93-109. https://doi.org/10.1016/S0939-6411(00)00144-2
9. Metia PK, Bandyopadhyay AK. In vitro evaluation of novel mucoadhesive buccal tablet of oxytocin prepared with Diospyros peregrine fruit mucilages, Yakugaku Zasshi 2008;128:603-609. https://doi.org/10.1248/yakushi.128.603
10. Rathbone MJ, Drummond BK and Tucker IG. The oral cavity as a site for systemic drug delivery, Adv. Drug Deliv. Rev., 1994;13:1-22. https://doi.org/10.1016/0169-409X(94)90024-8
11. Hyomin Jin, Hai V. Ngo, Chulhun Park, Beom-Jin Lee, Mucoadhesive buccal tablet of leuprolide and its fatty acid conjugate: Design, in vitro evaluation and formulation strategies, International Journal of Pharmaceutics, 2023;639:122963. https://doi.org/10.1016/j.ijpharm.2023.122963
12. Neelakandana RP, Divya R., Damodharan N. Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles. Nanofabrication, 2023;8:1-12. https://doi.org/10.37819/nanofab.008.296
13. Ankarao A, Ch.babu rao, Devanna K. Formulation and evaluation of buccoadhesive bilayered tablets of carvedilol. Int J Adv Pharm Sci. 2010;1(1):71-76.
14. Velmurugan S, Deepika B, Nagaraju K, Sundar V. Formulation and in-vitro evaluation of buccal tablets of piroxicam. Int. J. Pharm. Tech. Res. 2010;2(3):1958-1968.
15. Attama AA, P.A. Akpa, L.E. Onugwu, G. Igwilo., Novel buccoadhesive delivery system of Hydrochlorothiazide formulated with ethyl cellulose-Hydroxy propyl methylcellulose interpolymer complex. Scientific Research and Essay 2008;3(6):343-47
16. Emami J, Varshosaz J, Saljoughian N., Development and Evaluation of Controlled- release buccoadhesive Verapamil hydrochloride tablets. DARU 2008;16(2):60-69.
17. Takahashi Y, Takeda C, Seto I, Kawano G, Machida Y. Formulation and evaluation of lactoferrin bioadhesive tablets. Int. J. Pharm. 2007;343:220-227. https://doi.org/10.1016/j.ijpharm.2007.05.032
18. Simpson David M, Messina John, Xie Fang, and Hale Martin. Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: A multicancer, Randomized, Double Blind, Placebo-Controlled study. Clinical Therapeutics, 2007;29:588-601. https://doi.org/10.1016/j.clinthera.2007.04.007
19. Acholu PK, Yajaman S, Jayaveera KN. Ex-vivo and in-vivo evaluation of formulated novel felodipine core in cup buccal tablets. Asian J Biomed Pharm Sci2014;4(38):35-40. https://doi.org/10.15272/ajbps.v4i38.627
20. Ceschel GC, Maffei P, Lombardi BS and Ronchi C. Design and evaluation of buccal adhesive hydrocortisone acetate (HCA) tablets. Drug Deliv. 2001;8(3):161 - 171. https://doi.org/10.1080/107175401316906937
21. Varshosaz J and Dehghan Z. Development and characterization of buccoadhesive nifedipine tablets. Eur J Pharm Biopharm. 2002;54(2): 135-141 https://doi.org/10.1016/S0939-6411(02)00078-4
Published
PDF Downloads: 52
PDF Downloads: 5
How to Cite
Issue
Section
Copyright (c) 2024 Prapti V. Walse, Sandip T. Thoke , UMESH THAWARA JADHAO, Dharmaraj A. Rathod, Gunesh D. Dhembre, Vyankates R. Kauthekar, Sayyed Asad Ali
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).