In vitro Cyclooxygenase inhibitory activity and GC-MS profiling of bioactive compounds in Bauhinia racemosa Lam.

Authors

  • Ankit Yadav S.V.K.M’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Autonomous) Affiliated to University of Mumbai, Vile Parle- West, Mumbai-400056, India https://orcid.org/0009-0000-0959-2055
  • Meenakshi Vaidya S.V. K. M’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Empowered Autonomous) Affiliated to University of Mumbai, Vile-Parle (West), Mumbai 400056, India https://orcid.org/0000-0002-5203-4785

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are a common treatment for chronic pain and inflammation. While NSAIDs have been shown to reduce inflammation and pain associated with them, they have an array of side effects. Researchers investigated the COX inhibitory action of NSAIDs. They revealed that there are two distinct COX enzymes: COX-1 and COX2. Developing COX inhibitors has remained critical for producing innovative and safe anti-inflammatory drugs. Bauhinia racemosa Lam belonging to the family Fabaceae has a wide range of medicinal properties. The plant is used to treat various diseases in traditional medicine, but there is less knowledge based on clinical efficacy as an anti-inflammatory agent. In the present study Bauhinia racemosa Lam hydroalcoholic extract were screened for COX inhibition and GC-MS analysis was done to screen phytochemicals. The results obtained were found to inhibit 89% of COX activity significantly as compared to standard drug (Diclofenac sodium). GC-MS analysis revealed a total of ten potent bioactive compounds. The samples were identified by comparing retention time and peak area to literature and interpreting mass spectra. Results observed from the study suggest that the hydroalcoholic extract of Bauhinia racemosa Lam possess anti-inflammatory activity and can be utilized as an alternate source for NSAIDs.

Keywords: COX, Bauhinia racemosa Lam, Anti-inflammatory, NSAIDs.

Keywords:

COX, Bauhinia racemosa Lam, Anti-inflammatory, NSAIDs

DOI

https://doi.org/10.22270/jddt.v14i10.6847

Author Biographies

Ankit Yadav, S.V.K.M’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Autonomous) Affiliated to University of Mumbai, Vile Parle- West, Mumbai-400056, India

S.V. K. M’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Empowered Autonomous) Affiliated to University of Mumbai, Vile-Parle (West), Mumbai 400056, India.

Meenakshi Vaidya, S.V. K. M’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Empowered Autonomous) Affiliated to University of Mumbai, Vile-Parle (West), Mumbai 400056, India

S.V. K. M’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Empowered Autonomous) Affiliated to University of Mumbai, Vile-Parle (West), Mumbai 400056, India

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Published

15-10-2024
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How to Cite

1.
Yadav A, Vaidya M. In vitro Cyclooxygenase inhibitory activity and GC-MS profiling of bioactive compounds in Bauhinia racemosa Lam. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 21];14(10):49-53. Available from: https://jddtonline.info/index.php/jddt/article/view/6847

How to Cite

1.
Yadav A, Vaidya M. In vitro Cyclooxygenase inhibitory activity and GC-MS profiling of bioactive compounds in Bauhinia racemosa Lam. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 21];14(10):49-53. Available from: https://jddtonline.info/index.php/jddt/article/view/6847