Advances in Mucoadhesive drug Delivery System: Enhancing Efficacy and Patient Compliance
Abstract
The goal of mucoadhesive drug delivery systems (MDDS) is to improve drug delivery effectiveness by adhering to the body's mucosal tissues. The material used in this approach adheres to mucosal surfaces, including those in the mouth, gastrointestinal system, nasal passages, and vaginal walls. The most important goal is to extend the medication's residence duration at the absorption site in order to improve drug absorption and provide a more regulated and prolonged release. Mucoadhesion refers to the adhesion between two materials, one of which is biological, through interfacial forces over an extended period. This characteristic provides an effective solution to challenges in traditional drug delivery systems, such as avoiding first-pass metabolism and facilitating localized delivery of biomolecules, including proteins, peptides, and oligonucleotides. It holds significant promise for delivering compounds via routes like ocular, nasal, vaginal, and buccal administration This study addresses the introduction, benefits, drawbacks, mechanisms, and theories of mucoadhesion in addition to polymer categorization, mucoadhesive dosage forms, assessment, and factors affecting mucoadhesion and several kinds of mucoadhesive dosage forms.
Keywords: Mucoadhesion, Theories, Mucoadhesive Dosage Form, bio adhesion
Keywords:
Mucoadhesion, Theories, Mucoadhesive Dosage Form, bio adhesionDOI
https://doi.org/10.22270/jddt.v14i10.6836References
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