Advances in Mucoadhesive drug Delivery System: Enhancing Efficacy and Patient Compliance

Authors

  • Kiran H. Patil Department of Pharmaceutics, Prof. Ravindra Nikam Collage of Pharmacy Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India
  • Salman A. Mobin Department of Pharmaceutics, Prof. Ravindra Nikam Collage of Pharmacy Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India

Abstract

The goal of mucoadhesive drug delivery systems (MDDS) is to improve drug delivery effectiveness by adhering to the body's mucosal tissues. The material used in this approach adheres to mucosal surfaces, including those in the mouth, gastrointestinal system, nasal passages, and vaginal walls. The most important goal is to extend the medication's residence duration at the absorption site in order to improve drug absorption and provide a more regulated and prolonged release. Mucoadhesion refers to the adhesion between two materials, one of which is biological, through interfacial forces over an extended period. This characteristic provides an effective solution to challenges in traditional drug delivery systems, such as avoiding first-pass metabolism and facilitating localized delivery of biomolecules, including proteins, peptides, and oligonucleotides. It holds significant promise for delivering compounds via routes like ocular, nasal, vaginal, and buccal administration This study addresses the introduction, benefits, drawbacks, mechanisms, and theories of mucoadhesion in addition to polymer categorization, mucoadhesive dosage forms, assessment, and factors affecting mucoadhesion and several kinds of mucoadhesive dosage forms.

 Keywords:  Mucoadhesion, Theories, Mucoadhesive Dosage Form, bio adhesion

Keywords:

Mucoadhesion, Theories, Mucoadhesive Dosage Form, bio adhesion

DOI

https://doi.org/10.22270/jddt.v14i10.6836

Author Biographies

Kiran H. Patil, Department of Pharmaceutics, Prof. Ravindra Nikam Collage of Pharmacy Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India

Department of Pharmaceutics, Prof. Ravindra Nikam Collage of Pharmacy Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India

Salman A. Mobin, Department of Pharmaceutics, Prof. Ravindra Nikam Collage of Pharmacy Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India

Department of Pharmaceutics, Prof. Ravindra Nikam Collage of Pharmacy Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India

References

Alawdi S, Solanki AB. Mucoadhesive Drug Delivery Systems: A Review of Recent Developments. Journal of Scientific Research in Medical and Biological Sciences. 2021 Feb 28;2(1):50-64. https://doi.org/10.47631/jsrmbs.v2i1.213

Donnelly R, Shaikh R, Singh TR, Garland M, Woolfson Ad. Mucoadhesive drug delivery systems. Journal of Pharmacy and Bioallied Sciences. 2011 Jan 1;3(1):89. https://doi.org/10.4103/0975-7406.76478

Yermak IM, Davydova VN, Volod'ko AV. Mucoadhesive Marine Polysaccharides. Marine Drugs. 2022 Aug 15;20(8):522. https://doi.org/10.3390/md20080522

Boddupalli B, Mohammed Zulkar NK, Nath R, Banji D. Mucoadhesive drug delivery system: An overview. Journal of Advanced Pharmaceutical Technology & Research. 2010 Jan 1;1(4):381. https://doi.org/10.4103/0110-5558.76436

Rai̇ A, Rawat SS, Rathi̇ R, Rai̇Na D, Odeku OA, Si̇Ngh I. Mucoadhesive Drug Delivery Systems for Pediatric and Geriatric Patients. Fabad Journal of Pharmaceutical Sciences. 2023 Sep 13; https://doi.org/10.55262/fabadeczacilik.1279777

Sharma R, Kumar S, Malviya R, Prajapati BG, Puri D, Limmatvapirat S, et al. Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application. Journal of Drug Delivery Science and Technology. 2024 Jan 1;91:105227. https://doi.org/10.1016/j.jddst.2023.105227

Shirvan AR, Bashari A, Hemmatinejad N. New insight into the fabrication of smart mucoadhesive buccal patches as a novel controlled-drug delivery system. European Polymer Journal. 2019 Jul 8;119:541-50. https://doi.org/10.1016/j.eurpolymj.2019.07.010

Russo E, Selmin F, Baldassari S, Gennari CGM, Caviglioli G, Cilurzo F, et al. A focus on mucoadhesive polymers and their application in buccal dosage forms. Journal of Drug Delivery Science and Technology. 2015 Jun 24;32:113-25. https://doi.org/10.1016/j.jddst.2015.06.016

Cook SL, Bull SP, Methven L, Parker JK, Khutoryanskiy VV. Mucoadhesion: A food perspective. Food Hydrocolloids. 2017 Nov 1;72:281-96. https://doi.org/10.1016/j.foodhyd.2017.05.043

Nguyen S, Hiorth M. Advanced drug delivery systems for local treatment of the oral cavity. Therapeutic Delivery. 2015 May 1;6(5):595-608. https://doi.org/10.4155/tde.15.5

Kumar K, Dhawan N, Sharma H, Vaidya S, Vaidya B. Bioadhesive polymers: Novel tool for drug delivery. Artificial Cells Nanomedicine and Biotechnology. 2013 Jul 16;42(4):274-83. https://doi.org/10.3109/21691401.2013.815194

Ozakar RS, Ozakar E. Current Overview of Oral Thin Films. Turkish Journal of Pharmaceutical Sciences. 2021 Feb 1;18(1):111-21. https://doi.org/10.4274/tjps.galenos.2020.76390

Durante-Salmerón DA, Fraile-Gutiérrez I, Gil-Gonzalo R, Acosta N, Aranaz I, Alcántara AR. Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review. Catalysts. 2024 Jun 10;14(6):371. https://doi.org/10.3390/catal14060371

Chauhan V, Agrawal A, Singh UK. A Comprehensive Review on Mucoadhesive Drug Delivery. Journal of Drug Delivery and Therapeutics. 2022 Aug 15;12(4-S):199-209. https://doi.org/10.22270/jddt.v12i4-S.5610

Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery. 2020 Dec 4;20(2):101-24. https://doi.org/10.1038/s41573-020-0090-8

Prabahar K, Alanazi Z, Qushawy M. Targeted Drug Delivery System: Advantages, Carriers and Strategies. Indian Journal of Pharmaceutical Education and Research. 2021 May 17;55(2):346-53. https://doi.org/10.5530/ijper.55.2.72

Kumari L, Choudhari Y, Patel P, Gupta GD, Singh D, Rosenholm JM, et al. Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs. Life. 2023 Apr 27;13(5):1099. https://doi.org/10.3390/life13051099

Lou J, Duan H, Qin Q, Teng Z, Gan F, Zhou X, et al. Advances in Oral Drug Delivery Systems: Challenges and Opportunities. Pharmaceutics. 2023 Feb 1;15(2):484. https://doi.org/10.3390/pharmaceutics15020484

Pan Z, Zhang X, Xie W, Cui J, Wang Y, Zhang B, et al. Revisited and innovative perspectives of oral ulcer: from biological specificity to local treatment. Frontiers in Bioengineering and Biotechnology. 2024 Feb 22;12. https://doi.org/10.3389/fbioe.2024.1335377

Biswas M, Nurunnabi M, Khatun Z. Understanding Mucosal Physiology and Rationale of Formulation Design for Improved Mucosal Immunity. ACS Applied Bio Materials. 2024 May 24; https://doi.org/10.1021/acsabm.4c00395

Thompson CA, DeLaForest A, Battle MA. Patterning the gastrointestinal epithelium to confer regional-specific functions. Developmental Biology. 2018 Mar 1;435(2):97-108. https://doi.org/10.1016/j.ydbio.2018.01.006

Bej R, Haag R. Mucus-Inspired Dynamic Hydrogels: Synthesis and Future Perspectives. Journal of the American Chemical Society. 2022 Sep 8;144(44):20137-52. https://doi.org/10.1021/jacs.1c13547

Abrami M, Biasin A, Tescione F, Tierno D, Dapas B, Carbone A, et al. Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases. International Journal of Molecular Sciences. 2024 Feb 5;25(3):1933. https://doi.org/10.3390/ijms25031933

Uzundurukan A, Poncet S, Boffito DC, Micheau P. Acoustic airway clearance devices: A systematic review of experimental and numerical studies. Biomedical Engineering Advances. 2024 Sep 1;100134. https://doi.org/10.1016/j.bea.2024.100134

Widdicombe JH, Wine JJ. Airway Gland Structure and Function. Physiological Reviews. 2015 Sep 3;95(4):1241-319. https://doi.org/10.1152/physrev.00039.2014

Meldrum OW, Yakubov GE. Journey of dietary fiber along the gastrointestinal tract: role of physical interactions, mucus, and biochemical transformations. Critical Reviews in Food Science and Nutrition. 2024 Aug 14;1-29. https://doi.org/10.1080/10408398.2024.2390556

Ali J, Baboota S, Khar R, Md S, Sahni J, Singh G, et al. Mucoadhesive microspheres as a controlled drug delivery system for gastroretention. Systematic Reviews in Pharmacy. 2012 Jan 1;3(1):4. https://doi.org/10.4103/0975-8453.107130

Jawadi Z, Yang C, Haidar ZS, Maria PLS, Massa S. Bio-Inspired Muco-Adhesive Polymers for Drug Delivery Applications. Polymers. 2022 Dec 13;14(24):5459. https://doi.org/10.3390/polym14245459

Carvalho FC, Bruschi ML, Evangelista RC, Gremião MPD. Mucoadhesive drug delivery systems. Brazilian Journal of Pharmaceutical Sciences. 2010 Mar 1;46(1):1-17. https://doi.org/10.1590/S1984-82502010000100002

Yermak IM, Davydova VN, Volod'ko AV. Mucoadhesive Marine Polysaccharides. Marine Drugs. 2022 Aug 15;20(8):522. https://doi.org/10.3390/md20080522

Vigani B, Rossi S, Sandri G, Bonferoni MC, Caramella CM. Mucoadhesive polymers in substance-based medical devices: functional ingredients or what else? Frontiers in Drug Safety and Regulation. 2023 Aug 4;3. https://doi.org/10.3389/fdsfr.2023.1227763

Jurado LA, Espinosa-Marzal RM. Insight into the Electrical Double Layer of an Ionic Liquid on Graphene. Scientific Reports. 2017 Jun 19;7(1). https://doi.org/10.1038/s41598-017-04576-x

Vasquez-Martínez N, Guillen D, Moreno-Mendieta SA, Sanchez S, Rodríguez-Sanoja R. The Role of Mucoadhesion and Mucopenetration in the Immune Response Induced by Polymer-Based Mucosal Adjuvants. Polymers. 2023 Mar 24;15(7):1615. https://doi.org/10.3390/polym15071615

Donnelly R, Shaikh R, Singh TR, Garland M, Woolfson Ad. Mucoadhesive drug delivery systems. Journal of Pharmacy and Bioallied Sciences. 2011 Jan 1;3(1):89. https://doi.org/10.4103/0975-7406.76478

Bal-Ozturk A, Cecen B, Avci-Adali M, Topkaya SN, Alarcin E, Yasayan G, et al. Tissue adhesives: From research to clinical translation. Nano Today. 2020 Dec 20;36:101049. https://doi.org/10.1016/j.nantod.2020.101049

Namazi H. Polymers in our daily life. Bioimpacts. 2017 Jun 16;7(2):73-4. https://doi.org/10.15171/bi.2017.09

Campanale N, Massarelli N, Savino N, Locaputo N, Uricchio N. A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health. International Journal of Environmental Research and Public Health. 2020 Feb 13;17(4):1212. https://doi.org/10.3390/ijerph17041212

Balla E, Daniilidis V, Karlioti G, Kalamas T, Stefanidou M, Bikiaris ND, et al. Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties-From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications. Polymers. 2021 May 31;13(11):1822. https://doi.org/10.3390/polym13111822

Dhakar RC, Maurya SD, Aggarwal S, Kumar G, Tilak VK, Design and evaluation of SRM microspheres of metformin hydrochloride, Pharmacie Globale (IJCP), 2010; 1(1):1-5

Alawdi S, Solanki AB. Mucoadhesive Drug Delivery Systems: A Review of Recent Developments. Journal of Scientific Research in Medical and Biological Sciences. 2021 Feb 28;2(1):50-64. https://doi.org/10.47631/jsrmbs.v2i1.213

Kumar R, Islam T, Nurunnabi M. Mucoadhesive carriers for oral drug delivery. Journal of Controlled Release. 2022 Sep 30;351:504-59. https://doi.org/10.1016/j.jconrel.2022.09.024

Dhakar RC, Maurya SD, Tilak VK, Gupta AK, A review on factors affecting the design of nasal drug delivery system, International journal of drug delivery, 2011;3(2):194

Ritu Mg, Mohd I, Sunny S, Neeraj G. A clinical perspective on mucoadhesive buccal drug delivery systems. Journal of Biomedical Research. 2014 Jan 1;28(2):81. https://doi.org/10.7555/JBR.27.20120136

Dubashynskaya NV, Skorik YA. Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives. International Journal of Molecular Sciences. 2022 Oct 26;23(21):12980. https://doi.org/10.3390/ijms232112980

Karki S, Kim H, Na SJ, Shin D, Jo K, Lee J. Thin films as an emerging platform for drug delivery. Asian Journal of Pharmaceutical Sciences. 2016 Jun 6;11(5):559-74. https://doi.org/10.1016/j.ajps.2016.05.004

Rossi SS, Sandri G, Caramella CM. Buccal Delivery Systems for Peptides. American Journal of Drug Delivery. 2005 Jan 1;3(4):215-25. https://doi.org/10.2165/00137696-200503040-00002

Shipp L, Liu F, Kerai-Varsani L, Okwuosa TC. Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches. Journal of Controlled Release. 2022 Nov 18;352:1071-92. https://doi.org/10.1016/j.jconrel.2022.10.058

Yun GA, Choi SU, Park KH, Rhee YS, Lee BJ, Lee JH. Pharmaceutical Devices for Oral Cavity-based Local and Systemic Drug Delivery. Journal of Pharmaceutical Investigation. 2010 May 15;40(spc):113-8. https://doi.org/10.4333/KPS.2010.40.S.113

Oluwasina O, Ezenwosu IV, Ogidi CO, Oyetayo VO. Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms. AMB Express. 2019 Feb 4;9(1). https://doi.org/10.1186/s13568-019-0744-2

Algin-Yapar E. Nasal Inserts for Drug Delivery: An Overview. Tropical Journal of Pharmaceutical Research. 2014 May 27;13(3):459. https://doi.org/10.4314/tjpr.v13i3.22

Pandey M, Choudhury H, Abdul-Aziz A, Bhattamisra SK, Gorain B, Carine T, et al. Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update. Polymers. 2020 Dec 23;13(1):26. https://doi.org/10.3390/polym13010026

DeLima CS, Varca JPRO, Alves VM, Nogueira KM, Cruz CPC, Rial-Hermida MI, et al. Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer. Gels. 2022 Sep 15;8(9):587. https://doi.org/10.3390/gels8090587

Ezike TC, Okpala US, Onoja UL, Nwike CP, Ezeako EC, Okpara OJ, et al. Advances in drug delivery systems, challenges and future directions. Heliyon. 2023 Jun 1;9(6):e17488. https://doi.org/10.1016/j.heliyon.2023.e17488

Hanafy NAN, Leporatti S, El-Kemary MA. Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System. Applied Sciences. 2019 Feb 26;9(5):825. https://doi.org/10.3390/app9050825

Zhao K, Xie Y, Lin X, Xu W. The Mucoadhesive Nanoparticle-Based Delivery System in the Development of Mucosal Vaccines. International Journal of Nanomedicine. 2022 Sep 1;Volume 17:4579-98. https://doi.org/10.2147/IJN.S359118

Published

15-10-2024
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How to Cite

1.
Patil KH, Mobin SA. Advances in Mucoadhesive drug Delivery System: Enhancing Efficacy and Patient Compliance. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 21];14(10):166-74. Available from: https://jddtonline.info/index.php/jddt/article/view/6836

How to Cite

1.
Patil KH, Mobin SA. Advances in Mucoadhesive drug Delivery System: Enhancing Efficacy and Patient Compliance. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 21];14(10):166-74. Available from: https://jddtonline.info/index.php/jddt/article/view/6836