A Review of Polymyxin-B Dosage for Patients with Renal Impairment

Authors

Abstract

Since polymyxin B has a restricted therapeutic range and increased danger of both neurological damage and kidney damage, it is no longer the first choice for treating emerging gram-negative bacteria with multiple antibiotic resistance. The optimal dose schedule for patients with renal impairment regarding polymyxin B, it is provided as a chemically active formulation and primarily removed via methods other than kidney, is still up for debate. Similar to colistin, polymyxin-B effectively combats gram-negative aerobic bacterium that is resistant to several drugs such as Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli that produces carbapenemase, and Klebsiella pneumoniae. As a result, polymyxins cause cell apoptosis by inducing pan-caspase activation through many routes in a manner that is dependent on time and concentration. One of the most frequent and undesirable side effects of polymyxins is the development of AKI. A great deal of pharmacokinetic studies that have been published to far concur that creatinine clearance affects polymyxin B clearance; nevertheless, there is ongoing debate on the extent of this influence

Keywords: Polymyxin-B, kidney damage, gram-negative bacterial infection, creatinine clearance.

Keywords:

Polymyxin-B, kidney damage, gram-negative bacterial infection, creatinine clearance

DOI

https://doi.org/10.22270/jddt.v14i10.6810

Author Biographies

S Abdul Kadhar, Pharm -D Intern, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore

Pharm -D Intern, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore

S Parthasarathy, Pharm -D Intern, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore

Pharm -D Intern, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore

Karthick Murugesan, Assistant Professor, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore

Assistant Professor, Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore

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15-10-2024
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Abdul Kadhar S, Parthasarathy S, Murugesan K. A Review of Polymyxin-B Dosage for Patients with Renal Impairment. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 21];14(10):116-22. Available from: https://jddtonline.info/index.php/jddt/article/view/6810

How to Cite

1.
Abdul Kadhar S, Parthasarathy S, Murugesan K. A Review of Polymyxin-B Dosage for Patients with Renal Impairment. J. Drug Delivery Ther. [Internet]. 2024 Oct. 15 [cited 2025 Jan. 21];14(10):116-22. Available from: https://jddtonline.info/index.php/jddt/article/view/6810