Preparation and Characterization of Prednisolone Containing Nanoparticles for Treatment of Colon Disorder
Abstract
The point of flow research work is planning and portrayal of prednisolone containing nanoparticles by spray drying process using regular, semi engineered and manufactured polymers for treatment of colon problem. The pre-arranged Nanoparticles were assessed for Surface morphology, Medication entanglement effectiveness, differential filtering colorimetry, molecule size, Fourier change infrared spectroscopy, in-vitro drug release and X-beam diffraction studies. The pre-arranged Nanoparticles are smooth in surface and showing circular shape. The normal molecule sizes of the nanoparticles were tracked down in the scope of 523 nm to 901 nm. The medication exemplification effectiveness (EE) of the steroid containing nanoparticles were tracked down in the scope of 82.21%to 89.30%. Here the medication encapsulation efficiency of arranged nanoparticles were expanded with expansion in the fixation of the polymer. The X-beam diffractogram of drug has shown trademark serious top between the 2ө of 19.67 and 30 because of its translucent nature. Where as in the event of medication free Nanoparticles, no extreme pinnacles connected with drug. In drug stacked Nanoparticles peaks were saw between 2ө of 29.67 and 49. The in-vitro drug discharge information of the multitude of definitions were viewed as zero request and shown supported discharge over a time of 24hour.The FTIR Spectra of Nanoparticles detailing are contrasted and the spectra of unadulterated medication, there is no much deviation in the spectra's and not noticed any medication and polymer communications. The brief time frame dependability investigation of streamlined plan has done and exposed to sedate epitome effectiveness and In-vitro drug release studies, where results shown that there is no huge change in the detailing.
Keywords: Polymer, Steroids, FTIR, X-Ray, Prednisolone.
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Srujana S, Anjamma M, Alimuddin, Singh B, Dhakar RC, Natarajan S, Hechhu R. A Comprehensive Study on the Synthesis and Characterization of TiO2 Nanoparticles Using Aloe vera Plant Extract and Their Photocatalytic Activity against MB Dye. Adsorption Science & Technology. 2022;2022 https://doi.org/10.1155/2022/7244006
Udupa N, Mutalik S. "Recent trends in Novel drug delivery" Published by Prism Books Pvt.Ltd 2014.
Singh A, Sharma A, Pooja, Anju. Novel approaches for colon targeted drug delivery system, Int J of Res and Development in Pharmacy and Life Sciences. February - March, 2014;3(2):877-886.
Patel A, Bhatt N, Patel KR, Patel N.M,.Patel MR. Colon targeted drug delivery system: review system JPSBR: 2011;1(1):37-49). https://doi.org/10.4103/0975-8453.83431
Subashini Rajaram, Senthil Rajan Dharmalingam, Santhose Rani A, Sapthasri R, Varsha D, Vinodhini V, Prednisolone Encapsulated Superparamagnetic Iron Oxide Nanoparticles For Target Drug Delivery - Design And Quantification. Asian J Pharm Clin Res, 2019;12(11):126-131. https://doi.org/10.22159/ajpcr.2019.v12i11.35439
Nilesh M. Mahajan et al. Design and development of mesalamine loaded PLGA nanoparticles.,Journal of Pharmacy Research 2011;4(4):1263-1266.
Sharma N, Harikumar H.L. Formulation and evaluation of enteric coated Nanoparticales of Ketofprofen using natural polymers for colon drug delivery, Int J Pharm Pharm Sci, Vol 6, Suppl 2, 886-892.
Georgia Michailidou , nina maria ainali , eleftheria xanthopoulou , stavroula nanaki margaritis kostoglou , emmanuel n. koukaras and dimitrios n. bikiaris, effect of poly(vinyl alcohol) on nanoencapsulation of budesonide in chitosan nanoparticles via ionic gelation and its improved bioavailability. polymers 2020;12:1101; https://doi.org/10.3390/polym12051101 PMid:32408557 PMCid:PMC7285374
Liu Y, Zhou H. Budesonide loaded guar gum Nanoparticales for colon delivery: preparation, charecterizationand in vitro/in vivo evaluation. Int j of mol sci. 2015;16:2693- 2704. https://doi.org/10.3390/ijms16022693 PMid:25629228 PMCid:PMC4346859
Bihind SR, Nair R. Formulation and evaluation of coated Nanoparticales for colon targeting. J of Applied Phrm sci. 2013;3(8):68-74.
Mazumder R, Allamneni Y, Firdous SM, Parya H, Chowdhury AD. Formulation, development and in-vitro release effects of ethyl cellulose coated pectin Nanoparticales for colon targeting. Asian J of Phrm and clinical res.2013;6(5):138-144.
Prajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar RC, Dendrimers in drug delivery, diagnosis and therapy: basics and potential applications, Journal of Drug Delivery and Therapeutics. 2016;6(1):67-92 https://doi.org/10.22270/jddt.v6i1.1190
Shukla S, Jain D, Verma K. Formulation and in vitro characterization of alginate Nanoparticales loaded with diloxanide furoate for colon-specific drug delivery. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian JPharm. 2014 Aug 27;4(4).
Woong Park C, Jung Lee H, Won Oh D, Hyun Kang J, Soo Han C, Wook Kim D. Preparation and in vitro/in vivo evaluation of PLGA Nanoparticales containing norquetiapine for long-acting injection. Drug Design, Development and Therapy 2018;12:711-719. https://doi.org/10.2147/DDDT.S151437 PMid:29670329 PMCid:PMC5896679
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