Innovative Formulation and Evaluation of Phytosomal Nanoparticles from Ixora Coccinea Linn and its Pharmacological Screening

Keywords: Phytosomes, Nanoparticles, Solvent evaporation method, nvitro anti-inflammatory activity

Abstract

The use of herbal extracts in pharmaceutical formulations has gained significant attention due to their therapeutic potential and minimum side effects and shows pharmacological profiles as anti-inflammatory, anticancer, and antimicrobial. Thus, the intent of the current study was to develop a potential drug carrier system phytosomal nanoparticle using an extract of the plant “Ixora coccinea”. The extract of Ixora coccinea was prepared by using the maceration method and it is incorporated into Phytosome nanoparticles by using the solvent evaporation method. The impact of various process parameters and material attributes on the average particle size and drug entrapment efficacy. Extract loaded Phytosomal nanoparticles were characterized by particle size determination, Zeta potential, FTIR, and UV spectroscopy. The pharmacological screening consolidated antimicrobial activity was carried out by the well diffusion method, wherein it was performed against Gram Positive (B. Cerus, NCIM-2703) and Gram Negative (E. coli, NCIM 2832) bacteria strains. Which resulted in showing phytosomal nanoparticles show good activity than the extract. The anti-inflammatory activity was carried out by the protein denaturation method, which concluded that Ixora Coccinea phytosomal nanoparticles show better activity. Therefore, it results in moderate anti-inflammatory activity as compared to standard Diclofenac sodium.

Keywords: Phytosome nanoparticles, Solvent evaporation method, Invitro anti-inflammatory activity.

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Author Biographies

Shreyash Patil, R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

Swarali Patil, R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

Smita P. Kamalakar, R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

Suraj Patil, R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

Sujitkumar Patil, R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

Sulaxmi Patil, R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

R. L. Tawde Foundation’s Sarojini College of Pharmacy, Kolhapur, Maharashtra, India 416013

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Published
2024-08-15
How to Cite
1.
Patil S, Patil S, Kamalakar SP, Patil S, Patil S, Patil S. Innovative Formulation and Evaluation of Phytosomal Nanoparticles from Ixora Coccinea Linn and its Pharmacological Screening. JDDT [Internet]. 15Aug.2024 [cited 8Sep.2024];14(8):110-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6757