The Neuropharmacological Properties of Malkangni (Celastrus paniculatus Willd.): Insights from Unani Medicine and Pharmacological Research: A Review
Abstract
Malkangni, also known as Celastrus paniculatus Willd., is a herb widely used in the Unani system of medicine for its neuropharmacological properties. The seeds and oil of Malkangni have therapeutic benefits, including enhancing memory and cognitive functions. Malkangni exhibits a range of pharmacological activities, including neuroprotective, analgesic, anti-inflammatory, and antioxidant effects. It has shown potential to improve learning and memory, sedation, and anti-convulsive properties and treat conditions such as leprosy, rheumatism, diarrhea, and arthritis. The diverse pharmacological activities of Malkangni suggest its potential in treating various health conditions. This review aims to describe the medicinal properties and therapeutic applications of Malkangni through the perspective of Unani medicine and its phytochemical and pharmacological studies.
Keywords: Malkangni, Celastrus paniculatus, Unani medicine, traditional medicine, natural medicine
Downloads
References
Khan Azam. Muhit-i-Azam, vol 4. (Urdu translation by Central Council for Research in Unani Medicine), Ministry of AYUSH, Family Welfare and Health, Govt of India, New Delhi, 2018; 512-15.
Khare CP. Indian medicinal plants: an illustrated dictionary. Springer, Berlin/Heidelberg, 2007; 1-775. https://doi.org/10.1007/978-0-387-70638-2_1779
Ghani Najmul. Idara Kitab al-Shifa, New Delhi, 2011; 1211: 1212.
Kirtikara KR and Basu BD. Indian Medicinal Plants, Periodical Experts Book Egancy, Delhi. 2012; 1: 575-577.
Anonymous. National Formulary of Unani Medicine, Central Council for Research in Unani Medicine, Ministry of AYUSH, Family Welfare and Health, Govt of India, New Delhi, 2006; 197.
Kalam MA, Khanday S, Salim S, Nida K, Ahmad. A Malkangni (celastrus paniculatus willd.): neuropharmacological properties in perspective of unani medicine and pharmacological studies-a review, World Journal of Pharmacy and Pharmaceutical Sciences, 2011; 08(02):381-391.
Choudhary Arpita, Soni Pooja. Pharmacological Activities of Celastrus paniculata Wild: A Review, International Journal of Pharmaceutical Sciences Review and Research, 2021; 139-144. https://doi.org/10.47583/ijpsrr.2021.v69i01.021
Ketakee D, Nanda W S . Celastrus paniculatus: Medicinal and pharmacological properties: A review, International Journal of Development Research, 2015; 5(09):5526-31.
Anonymous. National Formulary of Unani Medicine, Central Council for Research in Unani Medicine, Ministry of AYUSH, Family Welfare and Health, Govt. of India, New Delhi, part-VI. 2011; 21,26, 64,78, 79,90,92,93.
Anonymous. National Formulary of Unani Medicine, vol. 1, part-2. Central Council for Research in Unani Medicine, Ministry of AYUSH, Family Welfare and Health, Govt of India, New Delhi, 2007; 44.
Anonymous. National Formulary of Unani Medicine, Part-V. Central Council for Research in Unani Medicine, Ministry of AYUSH, Family Welfare and Health, Govt of India, New Delhi, 2008; 84, 128, 151.
Anonymous. National Formulary of Unani Medicine, Central Council for Research in Unani Medicine, Ministry of AYUSH, Family Welfare and Health, Govt of India, New Delhi, 2006; 197.
Tu YQ, Wu TX, Li ZZ, Zhen T, Chen YZ. Sesquiterpene polyol esters from Celastrus paniculatus. Magn Reson Chem 2005;7: 650-5.
K, Webster HK, Nanavati DD. Chemistry and pharmacology of Celastrus paniculatus wild against plasmodium falciparum in vitro. Phytother Res 1989;4: 136-9. https://doi.org/10.1002/ptr.2650030405
Sengupta A, Bhargava HN. Chemical investigation of the seed of Celastrus paniculatus. J Sci Food Agric 1970;18: 628-31. https://doi.org/10.1002/jsfa.2740211207
Denhertog JR, Kruk C, Nanavati DD, Sukh Dev. Stereochemistry of malkanguniol and stereo structures of some other related polyalcohols from Celastrus paniculatus wild. Tetrahedron Lett 1974;26: 2219-22. https://doi.org/10.1016/S0040-4039(01)92217-8
Henry TA. The plant alkaloids. 4th edition. Jand A Churchill Ltd; London; 1949.
Ramadan MF. Celastrus paniculatus oil. Fruit oils: Chemistry and functionality. Springer Cham; 2019. https://doi.org/10.1007/978-3-030-12473-1
Basu NK, Pabrai PR. A chemical investigation of Celastrus paniculatus wild. J Pharm Sci 1946;9: 272-3. https://doi.org/10.1002/jps.3030350906 PMid:21002906
Gamlath CB, Gunatilaka AAL, Tejuka Y, Kikuchi T, Balasubramaniam S. Qunine-methide, phenolic and related triterpenoids of plants of celastraceae: further evidence for the structure of Celastranhydride. Phytochemistry 1990;10 :3189-92. https://doi.org/10.1016/0031-9422(90)80182-G
Chopra and Khanna. Conservation of some useful medicinal plants of Hardwar district in Uttaranchal state. Medicinal plants: Conservation and Cultivation; 2007: 147-66.
Parotta JA. Healing plants of peninsular India. CFBI, New York; 2001. https://doi.org/10.1079/9780851995014.0000
Jadeja BA, Odera NK, Gajera MR. Plants used in traditional phytotherapy for hair care in Gujarat, India, Jodhpur, Scientific Publications; 2006. p. 258-68.
Patil HM, Bhaskar VV. Medicinal uses of plants by tribal medicine men of Nandurbar District in Maharashtra. Nat Prod Rad 2006;2: 125-30.
Bhosale SV, Ghule VP, Aundhe DJ, Jagtap SD. Ethanomedical knowledge of plants used by tribal people of Purandhar in Maharashtra, India. Ethanobot Leaflets 2006;13: 1353-61.
Patil RH, Prakash K, Maheshwari VL. Hypolipidemic effect of Celastrus paniculatus on experimentally induced hyper cholesterolemic wistar rats. Indian J Clin Biochem 2010;4: 405-10. https://doi.org/10.1007/s12291-010-0050-x PMid:21966115 PMCid:PMC2994564
M. bhanumaty, s.b. chandrasekar, phyto-pharmacology of c.paniculatus.ISSN 0975.
Sumathi, T., Chandrasekar, S., Varadharajan, M., Ramachandran S., Manogaran S., Arunachalam, V. and Krishnamoorthi, R. Oxidative stress in brains of male rats intoxicated with Aluminium and Neuromodulating effect of Celastrus paniculatus alcoholic seed extract. Asian J. Pharm. Clin. Res. 2013;6(3): 80-90.
Karanth, K.S., Haridas, K.K., Gunasundari, S. and Guruswami, M.N. Effect of Celastrus paniculatus on learning process. J. Arogya. 1980; 6: 137-139.
Gattu M., Pauly JR, Boss KL, Summers JB, Buccafusco JJ. Cognitive impairment in spontaneously hypertensive rats: Role of central nicotinic receptors. Part I. Brain Res., 1997; 771:89-103. https://doi.org/10.1016/S0006-8993(97)00793-2 PMid:9383012
Fatema tuz zohera, comparative antioxidant potential of different extract of c. paniculatus willd.seed,S.J.Pharm.sci.3(1):68-74. https://doi.org/10.3329/sjps.v3i1.6802
Saini, kamal, effect of c.paniculatus on learing, memory and serum biochemistry of aging albino rats,indian joural of gernontology;2006;20(4): 310.
S.S Gatinode BB, Raiker KP, Shroff FN, Patel JR. Pharmacological studies with malkanguni, an indigenous tranquilizing drug (preliminary report). Current Practice,1957; 1: 619-621.
Russo A, Izzo AA, Cardile V, Borrelli F, Vanella A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomed. 2001;8(2): 125-132, (2001). https://doi.org/10.1078/0944-7113-00021 PMid:11315755
Kulkarni YA, Agarwal S, Garud MS. Effects of Jyotishmati (Celastrus paniculatus) seeds in animal model of pain and inflammation. J Ayur Integr Med. 2015; 2:82-8. https://doi.org/10.4103/0975-9476.146540 PMid:26166997 PMCid:PMC4484053
Singh S, Srivastava R, Choudhary S. Antifungal activity and HPLC analysis of crude extracts of Acorus calamus, Tinospora cordifolia and Celastrus paniculatus. J Agric-Tech. 2010; 1:149-58.
Copyright (c) 2024 Rayees Ahmad Mir, Farheen Zehra, Mohd Nayab, Abdul Nasir Ansari
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).