Liquid Chromatography-Mass Spectrometry: A Review

  • Tadikonda Rama Rao Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India https://orcid.org/0000-0003-1746-2167
  • Thangadipalli Yashwanth Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India
  • Banuri Usha Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

Abstract

The analytical technique known as liquid chromatography-mass spectrometry is incredibly precise and sensitive. It's a really powerful tool. Detection, identification, and mass determination of components in the presence of additional components are carried out by mass spectrometry using sample eluents from liquid chromatography and mass spectrometry. Liquid chromatography is used to identify pharmaceutical medication components, intermediates, and related compounds for both quantitative and qualitative applications. Liquid chromatography is mostly used in-vitro dissolution, bioequivalence, bioavailability, and metabolite research. Liquid chromatography mass spectrometry is also used in forensic labs, agrochemical firms, fundamental research, and the food industry. Applications, instrumentation, and the liquid chromatography-mass spectrometry principle are covered in this review.


Keywords: Liquid Chromatography, Mass Spectrometry, High Performance Liquid Chromatography, Bioequivalence, Metabolite research.

Keywords: Liquid Chromatography, Mass Spectrometry, High Performance Liquid Chromatography, Bioequivalence, Metabolite research

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Author Biographies

Tadikonda Rama Rao, Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

Thangadipalli Yashwanth, Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

Banuri Usha, Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad, India

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Rama Rao T, Yashwanth T, Usha B. Liquid Chromatography-Mass Spectrometry: A Review. JDDT [Internet]. 15Jun.2024 [cited 17Jul.2024];14(6):298-04. Available from: https://jddtonline.info/index.php/jddt/article/view/6669