A Review on Microspheres as a Promising Drug Carrier
Abstract
The targeted drug delivery is designed for endeavouring to concentrate the drug in the tissues of curiosity while reducing relative concentration of medication in the remaining tissues. There for drug is localized on the targeted site. Hence, surrounding tissues are not affected by the drug. Controlled drug delivery systems can overcome the issues associated with conventional medication therapy and improve a drug's therapeutic efficacy. Microspheres are free-flowing powders made of proteins or synthetic polymers with particle sizes ranging from 1 to 1000 µm. The multiplicity of techniques for preparing microspheres provides numerous chances to manage elements of drug administration and improve the therapeutic efficacy of a certain medicine. There are several techniques for delivering a medicinal chemical to the target region in a prolonged controlled release manner. Microspheres contain a drug encased in a unique polymeric membrane, making them ideal for novel drug delivery strategies such as diseased cell sorting, diagnostics, gene and genetic materials, safe and effective in vivo delivery, and supplements as miniature versions of diseased organs and tissues.
Keywords: Microspheres, Controlled release Therapeutic effectiveness, novel medication delivery.
Keywords:
Microspheres, Controlled release Therapeutic effectiveness, novel medication deliveryDOI
https://doi.org/10.22270/jddt.v14i7.6656References
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4. Ahmad W, Quazi J, Khan R, Ahmad N, Ansari N, A Comprehensive Review on Microspheres, Asian Journal of Pharmacy and Technology, 2022; 12 (2): 136-140. https://doi.org/10.52711/2231-5713.2022.00023
5. Dhakar RC, Maurya SD, Saluja V, From formulation variables to drug entrapment efficiency of microspheres: a technical review, Journal of Drug Delivery and Therapeutics, 2012;2(6):128-133 https://doi.org/10.22270/jddt.v2i6.160
6. Nguyen Thi Thanh Uyen, Zuratul Ain Abdul Hamid, Fabrication of alginate microspheres for drug delivery, International journal of biological macromolecules, 2020; 153: 1035-1046. https://doi.org/10.1016/j.ijbiomac.2019.10.233 PMid:31794824
7. Dhamapurkar SP, Desai DM, A review on microsphere for novel drug delivery system, World Journal of Advanced Research and Reviews, 2022, 16(03), 529-538. https://doi.org/10.30574/wjarr.2022.16.3.1368
8. Khalid, M Gautam A, Microsphere A Novel Drug Delivery System - A Review, International Journal of Scientific Research in Science and Technology,2023;10:406-411. https://doi.org/10.32628/IJSRST2310155
9. Wong CY, Al-Salami H, Crispin R Dass, Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin, International journal of pharmaceutics, 2018; 537(1-2): 223-244. https://doi.org/10.1016/j.ijpharm.2017.12.036 PMid:29288095
10. Lengyel M, Kállai-Szabó N, Antal V, Laki AJ, Antal I, Microparticles, microspheres, and microcapsules for advanced drug delivery, Scientia Pharmaceutica, 2019; 87(3):20. https://doi.org/10.3390/scipharm87030020
11. Kumar T, Ingle G, Pande SD, Sawarkar R, Padole D, The Current Trends in Microspheres: A Review, Journal of Drug Delivery and Therapeutics, 2023; 13(1):183-194. https://doi.org/10.22270/jddt.v13i1.5915
12. Yawalkar AN, Pawar MA, Vavia PR, Microspheres for targeted drug delivery-A review on recent applications, Journal of Drug Delivery Science and Technology, 2022; 75:103659. https://doi.org/10.1016/j.jddst.2022.103659
13. Dastidar DG, Saha S, Chowdhury M, Porous microspheres: Synthesis, characterisation and applications in pharmaceutical & medical fields, International journal of pharmaceutics, 2018; 548(1): 34-48. https://doi.org/10.1016/j.ijpharm.2018.06.015 PMid:29940297
14. Gavali KV, Kengar MD, Chavan KV, Anekar VP, Khan NI, A Review on Microsphere and it's Application, Asian Journal of Pharmaceutical Research, 2019;9(2):123-129. https://doi.org/10.5958/2231-5691.2019.00020.0
15. Doucet J, Kiri L, Advances in degradable embolic microspheres: a state of the art review, Journal of functional biomaterials, 2018; 9(1): 14. https://doi.org/10.3390/jfb9010014 PMid:29373510 PMCid:PMC5872100
16. Yang C, Zhang Z, Gan L, Zhang L, Yang L, Wu P, Application of biomedical microspheres in wound healing, International Journal of Molecular Sciences, 2023; 24(8): 7319. https://doi.org/10.3390/ijms24087319 PMid:37108482 PMCid:PMC10138683
17. Shi W, Ching Y, Chuah CH, Preparation of aerogel beads and microspheres based on chitosan and cellulose for drug delivery, International journal of biological macromolecules, 2021; 170: 751-767. https://doi.org/10.1016/j.ijbiomac.2020.12.214 PMid:33412201
18. Chadalawada P.K, Lavanya.P., Umashankar. D, Formulation and evaluation of sustained release saxagliptin microspheres by ionotropic gelation method. International Journal of Bioassays. 2017; 5328- 5333. https://doi.org/10.21746/ijbio.2017.03.0010
19. Lian Ruan, Mengrong Su, Xinyun Qin, Qingting Ruan, Wen Lang, Minhui Wu, Yujie Chen, Progress in the application of sustained-release drug microspheres in tissue engineering, Materials Today Bio, 2022; 16: 100394. https://doi.org/10.1016/j.mtbio.2022.100394 PMid:36042853 PMCid:PMC9420381
20. Yafei Gao, Jianmin Zhang, Jia Liang, Dongming Yuan, Weizhen Zhao, Research progress of poly (methyl methacrylate) microspheres: preparation, functionalization and application, European Polymer Journal, 2022; 175: 111379. https://doi.org/10.1016/j.eurpolymj.2022.111379
21. Shraddha Prashant Dhamapurkar, Deepa Mahendra Desai, A review on microsphere for novel drug delivery system, World Journal of Advanced Research and Reviews, 2022; 16(3): 529-538. https://doi.org/10.30574/wjarr.2022.16.3.1368
22. Yadav R, Bhowmick M, Rathi V, Rathi J, Design and characterization of floating microspheres for rheumatoid arthritis, Journal of Drug Delivery and Therapeutics 2019; 9(2):76-81.
23. Saini S, Kumar S, Choudhary M, Nitesh, Budhwar V. Microspheres as controlled drug delivery system: an updated review. International journal of pharmaceutical sciences and research. 2018;9(5):1760-8. Doi:10.13040/IJPSR.0975-8232.9(5).1760-68. https://doi.org/10.13040/IJPSR.0975-8232.9(5).1760-68
24. Nigam J, Pandey P; Mishra MK. Formulation and evaluation of anti- emetic microspheres for nasal drug delivery system. Indian J Novel Drug Delivery 2017: 9:44-53.
25. Singh S, Devi A, Sharma S, Sabharwal S, Sharma S, Dhiman S, Chauhan S, A Review on Microspheres and Its Role in Different Drug Delivery System as a Novel Approach, International Journal of Pharmaceutical Sciences,2024;(2)6:1112-1126.
26. Thundimadathil J, Peptide therapeutics: strategy and tactics for chemistry manufacturing and controls. In: Srivastava V. editor. Formulations of microspheres and nanoparticles for peptide delivery. 1st edition. Cryodon: Royal Society of Chemistry; 2019: 503-30. https://doi.org/10.1039/9781788016445-00503
27. Gavhane P, Deshmukh M, Khopade AN, Kunjir VV, Shete RV. A review on microsphere. Journal of Drug Delivery and Therapeutics. 2021; 11(1):188-94. https://doi.org/10.22270/jddt.v11i1.4501
28. Rise Desnita, Eka Noviana, Khadijah Zai, Teuku Nanda Saifullah Sulaiman, An Up-To-Date Review: Microspheres As A New Drug Delivery System, International Journal of Applied Pharmaceutics, 2023;15(6):82-89. https://doi.org/10.22159/ijap.2023v15i6.49120
29. Liu W, Borrell MA, Venerus DC, Mieler WF, Kang Mieler JJ. Characterization of biodegradable microsphere-hydrogel ocular drug delivery system for controlled and extended release of ranibizumab. Curr Eye Res 2018; 44:264-74. https://doi.org/10.1080/02713683.2018.1533983 PMid:30295090 PMCid:PMC7216294
30. Choudhary P, Yadav S, Asija R, A review on natural polymer-based microsphere, World Journal of Biology Pharmacy and Health Sciences, 2022, 12(03), 088-093. https://doi.org/10.30574/wjbphs.2022.12.3.0230
31. Usha Lakshmi P, Tejaswini K, Hemalatha B, Padmalatha K, Microspheres: A Comprehensive Review, Asian Journal of research in pharmaceutical sciences, 2023;13(3):235-0. https://doi.org/10.52711/2231-5659.2023.00041
32. Jadhav AP, Kedar TR, Jagtap RN. Formulation and Evaluation of Microspheres: A Review. International Journal for Research Trends and Innovation. 2022; 7(6): 311 - 315.
33. Chauhan P, Paliwal H, Ganugula SK, Chauhan CS, Paliwal A. Recent Advancements of Microspheres for The Management of Diabetes. Research Journal of Pharmacy and Technology 2023; 16(2):924-0. https://doi.org/10.52711/0974-360X.2023.00155
34. Shallu, Review on Microspheres, International Journal of Health and Clinical Research, 2023;6(3):4-9.
35. Joshi V, Velhal A, Patil S, Redasani VK, Raut P, Bhosale N, An Overview on Novel Drug Delivery System of Microsphere and its Types, Materials, Method of Preparation, Asian Journal of Pharmaceutical Research and Development,2023;11(4)106-114.
36. Xuebing Li, Luohuizi Li, ta Dehui Wang, Jun Zhang, Kangfeng Yi, Yucai Su, Jing Luo, a Xu Deng, Fabrication of polymeric microspheres for biomedical applications, Materials Horizons,2024;(11)2820-2855. https://doi.org/10.1039/D3MH01641B PMid:38567423
37. Singh P, Gilhotra RM, Formulation and evaluation of guar gum based matrix tableted glibenclamide microspheres, International Journal of Research in Pharmaceutical Sciences, 2020;11(2): 2445-2457. https://doi.org/10.26452/ijrps.v11i2.2238
38. Pradhan NC, Agarwal S, Singhal N, Garg YK. Kumar J, Microspheres: A Short Overall Review, International Journal of Allied Medical Sciences and Clinical Research,2020;8(4)795-796.
39. Dhakar RC, Maurya SD, Aggarwal S, Kumar G, Tilak VK, Design and Evaluation of SRM Microspheres of Metformin Hydrochloride, Pharmacie Globale (IJCP), 2010;1(07).
40. Lachman LA, Liberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. Varghese Publishing House, Mumbai, India: (3);414-415.
2. Dhadde Gurunath S, Mali Hanmant S., Raut Indrayani D., Nitalikar Manoj M., Bhutkar Mangesh A, A Review on Microspheres: Types, Method of Preparation, Characterization and Application, Asian Journal of Pharmacy and Technology,2021:11(2):1-7. https://doi.org/10.52711/2231-5713.2021.00025
3. Rastogi Vaibhav, Shukla Shiv Satya, Singh Roop, Niharika Lal, Yadav Pragya, Microspheres A Promising Drug Carrier, Journal of Drug Delivery and Therapeutics, 2016; 6(3):18-26. https://doi.org/10.22270/jddt.v6i3.1196
4. Ahmad W, Quazi J, Khan R, Ahmad N, Ansari N, A Comprehensive Review on Microspheres, Asian Journal of Pharmacy and Technology, 2022; 12 (2): 136-140. https://doi.org/10.52711/2231-5713.2022.00023
5. Dhakar RC, Maurya SD, Saluja V, From formulation variables to drug entrapment efficiency of microspheres: a technical review, Journal of Drug Delivery and Therapeutics, 2012;2(6):128-133 https://doi.org/10.22270/jddt.v2i6.160
6. Nguyen Thi Thanh Uyen, Zuratul Ain Abdul Hamid, Fabrication of alginate microspheres for drug delivery, International journal of biological macromolecules, 2020; 153: 1035-1046. https://doi.org/10.1016/j.ijbiomac.2019.10.233 PMid:31794824
7. Dhamapurkar SP, Desai DM, A review on microsphere for novel drug delivery system, World Journal of Advanced Research and Reviews, 2022, 16(03), 529-538. https://doi.org/10.30574/wjarr.2022.16.3.1368
8. Khalid, M Gautam A, Microsphere A Novel Drug Delivery System - A Review, International Journal of Scientific Research in Science and Technology,2023;10:406-411. https://doi.org/10.32628/IJSRST2310155
9. Wong CY, Al-Salami H, Crispin R Dass, Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin, International journal of pharmaceutics, 2018; 537(1-2): 223-244. https://doi.org/10.1016/j.ijpharm.2017.12.036 PMid:29288095
10. Lengyel M, Kállai-Szabó N, Antal V, Laki AJ, Antal I, Microparticles, microspheres, and microcapsules for advanced drug delivery, Scientia Pharmaceutica, 2019; 87(3):20. https://doi.org/10.3390/scipharm87030020
11. Kumar T, Ingle G, Pande SD, Sawarkar R, Padole D, The Current Trends in Microspheres: A Review, Journal of Drug Delivery and Therapeutics, 2023; 13(1):183-194. https://doi.org/10.22270/jddt.v13i1.5915
12. Yawalkar AN, Pawar MA, Vavia PR, Microspheres for targeted drug delivery-A review on recent applications, Journal of Drug Delivery Science and Technology, 2022; 75:103659. https://doi.org/10.1016/j.jddst.2022.103659
13. Dastidar DG, Saha S, Chowdhury M, Porous microspheres: Synthesis, characterisation and applications in pharmaceutical & medical fields, International journal of pharmaceutics, 2018; 548(1): 34-48. https://doi.org/10.1016/j.ijpharm.2018.06.015 PMid:29940297
14. Gavali KV, Kengar MD, Chavan KV, Anekar VP, Khan NI, A Review on Microsphere and it's Application, Asian Journal of Pharmaceutical Research, 2019;9(2):123-129. https://doi.org/10.5958/2231-5691.2019.00020.0
15. Doucet J, Kiri L, Advances in degradable embolic microspheres: a state of the art review, Journal of functional biomaterials, 2018; 9(1): 14. https://doi.org/10.3390/jfb9010014 PMid:29373510 PMCid:PMC5872100
16. Yang C, Zhang Z, Gan L, Zhang L, Yang L, Wu P, Application of biomedical microspheres in wound healing, International Journal of Molecular Sciences, 2023; 24(8): 7319. https://doi.org/10.3390/ijms24087319 PMid:37108482 PMCid:PMC10138683
17. Shi W, Ching Y, Chuah CH, Preparation of aerogel beads and microspheres based on chitosan and cellulose for drug delivery, International journal of biological macromolecules, 2021; 170: 751-767. https://doi.org/10.1016/j.ijbiomac.2020.12.214 PMid:33412201
18. Chadalawada P.K, Lavanya.P., Umashankar. D, Formulation and evaluation of sustained release saxagliptin microspheres by ionotropic gelation method. International Journal of Bioassays. 2017; 5328- 5333. https://doi.org/10.21746/ijbio.2017.03.0010
19. Lian Ruan, Mengrong Su, Xinyun Qin, Qingting Ruan, Wen Lang, Minhui Wu, Yujie Chen, Progress in the application of sustained-release drug microspheres in tissue engineering, Materials Today Bio, 2022; 16: 100394. https://doi.org/10.1016/j.mtbio.2022.100394 PMid:36042853 PMCid:PMC9420381
20. Yafei Gao, Jianmin Zhang, Jia Liang, Dongming Yuan, Weizhen Zhao, Research progress of poly (methyl methacrylate) microspheres: preparation, functionalization and application, European Polymer Journal, 2022; 175: 111379. https://doi.org/10.1016/j.eurpolymj.2022.111379
21. Shraddha Prashant Dhamapurkar, Deepa Mahendra Desai, A review on microsphere for novel drug delivery system, World Journal of Advanced Research and Reviews, 2022; 16(3): 529-538. https://doi.org/10.30574/wjarr.2022.16.3.1368
22. Yadav R, Bhowmick M, Rathi V, Rathi J, Design and characterization of floating microspheres for rheumatoid arthritis, Journal of Drug Delivery and Therapeutics 2019; 9(2):76-81.
23. Saini S, Kumar S, Choudhary M, Nitesh, Budhwar V. Microspheres as controlled drug delivery system: an updated review. International journal of pharmaceutical sciences and research. 2018;9(5):1760-8. Doi:10.13040/IJPSR.0975-8232.9(5).1760-68. https://doi.org/10.13040/IJPSR.0975-8232.9(5).1760-68
24. Nigam J, Pandey P; Mishra MK. Formulation and evaluation of anti- emetic microspheres for nasal drug delivery system. Indian J Novel Drug Delivery 2017: 9:44-53.
25. Singh S, Devi A, Sharma S, Sabharwal S, Sharma S, Dhiman S, Chauhan S, A Review on Microspheres and Its Role in Different Drug Delivery System as a Novel Approach, International Journal of Pharmaceutical Sciences,2024;(2)6:1112-1126.
26. Thundimadathil J, Peptide therapeutics: strategy and tactics for chemistry manufacturing and controls. In: Srivastava V. editor. Formulations of microspheres and nanoparticles for peptide delivery. 1st edition. Cryodon: Royal Society of Chemistry; 2019: 503-30. https://doi.org/10.1039/9781788016445-00503
27. Gavhane P, Deshmukh M, Khopade AN, Kunjir VV, Shete RV. A review on microsphere. Journal of Drug Delivery and Therapeutics. 2021; 11(1):188-94. https://doi.org/10.22270/jddt.v11i1.4501
28. Rise Desnita, Eka Noviana, Khadijah Zai, Teuku Nanda Saifullah Sulaiman, An Up-To-Date Review: Microspheres As A New Drug Delivery System, International Journal of Applied Pharmaceutics, 2023;15(6):82-89. https://doi.org/10.22159/ijap.2023v15i6.49120
29. Liu W, Borrell MA, Venerus DC, Mieler WF, Kang Mieler JJ. Characterization of biodegradable microsphere-hydrogel ocular drug delivery system for controlled and extended release of ranibizumab. Curr Eye Res 2018; 44:264-74. https://doi.org/10.1080/02713683.2018.1533983 PMid:30295090 PMCid:PMC7216294
30. Choudhary P, Yadav S, Asija R, A review on natural polymer-based microsphere, World Journal of Biology Pharmacy and Health Sciences, 2022, 12(03), 088-093. https://doi.org/10.30574/wjbphs.2022.12.3.0230
31. Usha Lakshmi P, Tejaswini K, Hemalatha B, Padmalatha K, Microspheres: A Comprehensive Review, Asian Journal of research in pharmaceutical sciences, 2023;13(3):235-0. https://doi.org/10.52711/2231-5659.2023.00041
32. Jadhav AP, Kedar TR, Jagtap RN. Formulation and Evaluation of Microspheres: A Review. International Journal for Research Trends and Innovation. 2022; 7(6): 311 - 315.
33. Chauhan P, Paliwal H, Ganugula SK, Chauhan CS, Paliwal A. Recent Advancements of Microspheres for The Management of Diabetes. Research Journal of Pharmacy and Technology 2023; 16(2):924-0. https://doi.org/10.52711/0974-360X.2023.00155
34. Shallu, Review on Microspheres, International Journal of Health and Clinical Research, 2023;6(3):4-9.
35. Joshi V, Velhal A, Patil S, Redasani VK, Raut P, Bhosale N, An Overview on Novel Drug Delivery System of Microsphere and its Types, Materials, Method of Preparation, Asian Journal of Pharmaceutical Research and Development,2023;11(4)106-114.
36. Xuebing Li, Luohuizi Li, ta Dehui Wang, Jun Zhang, Kangfeng Yi, Yucai Su, Jing Luo, a Xu Deng, Fabrication of polymeric microspheres for biomedical applications, Materials Horizons,2024;(11)2820-2855. https://doi.org/10.1039/D3MH01641B PMid:38567423
37. Singh P, Gilhotra RM, Formulation and evaluation of guar gum based matrix tableted glibenclamide microspheres, International Journal of Research in Pharmaceutical Sciences, 2020;11(2): 2445-2457. https://doi.org/10.26452/ijrps.v11i2.2238
38. Pradhan NC, Agarwal S, Singhal N, Garg YK. Kumar J, Microspheres: A Short Overall Review, International Journal of Allied Medical Sciences and Clinical Research,2020;8(4)795-796.
39. Dhakar RC, Maurya SD, Aggarwal S, Kumar G, Tilak VK, Design and Evaluation of SRM Microspheres of Metformin Hydrochloride, Pharmacie Globale (IJCP), 2010;1(07).
40. Lachman LA, Liberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. Varghese Publishing House, Mumbai, India: (3);414-415.
Published
15-07-2024
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Yadav M, Mandhare TA, Jadhav V, Otari K. A Review on Microspheres as a Promising Drug Carrier. J. Drug Delivery Ther. [Internet]. 2024 Jul. 15 [cited 2025 Feb. 18];14(7):120-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6656
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How to Cite
1.
Yadav M, Mandhare TA, Jadhav V, Otari K. A Review on Microspheres as a Promising Drug Carrier. J. Drug Delivery Ther. [Internet]. 2024 Jul. 15 [cited 2025 Feb. 18];14(7):120-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6656
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