Glanzmann’s Thrombocytopenia: A Case Report
Abstract
Glanzmann’s thrombocytopenia is a platelet disorder in which platelets have qualitative or quantitative deficiencies of the fibrinogen receptor α2bβ3. Most cases are hereditary but can be acquired also. This disorder in named after Dr.Eduard Glanzmann, who first described it in 1918. Its global prevalence is estimated to be one in a million with higher prevalence rate in population where consanguinity marriage is common. It has good prognosis with proper supportive care.
Case Summary: A 17-year male patient had come with complaint of severe epistaxis randomly for hours in a known case of Glanzmann’s thrombocytopenia which was diagnosed 10 years ago. With epistaxis he also had complaints of weakness in upper limbs and gastrocnemius muscle
Diagnosis: Glanzmann’s thrombocytopenia
Treatment: Inj. Etamsylate 500mg BD, Inj. Hemocoagulase 1IU OD, Inj. Tranexamic acid 500mg OD, Tab. Vitamin C BD, Tab. Calcium gluconate 500mg BD, Syp. Vitamin D3 and was transfused with PCV (A+) total 12 pint (200ml) and platelets 2 pint (200ml)
Keywords: Glanzmann’s thrombocytopenia, Epistaxis, Tranexamic acid, Congenital, Platelet Disorder.
Keywords:
Glanzmann’s thrombocytopenia, Epistaxis, Tranexamic acid, Congenital, Platelet DisorderDOI
https://doi.org/10.22270/jddt.v14i6.6654References
Swathi J, Gowrishankar A, Jayakumar SA, Jain K. A rare case of bleeding disorder: Glanzmann's thrombasthenia. Ann Afr Med. 2017 Oct-Dec;16(4):196-198. https://doi.org/10.4103/aam.aam_59_16 PMid:29063905 PMCid:PMC5676411 https://medlineplus.gov/genetics/condition/glanzmann-thrombasthenia/#description
Sebastiano C, Bromberg M, Breen K, Hurford MT. Glanzmann's thrombasthenia: report of a case and review of the literature. Int J Clin Exp Pathol. 2010 Apr 25;3(4):443-7. PMID: 20490335; PMCID: PMC2872751.
Krause KA, Graham BC. Glanzmann Thrombasthenia. [Updated 2022 May 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
https://emedicine.medscape.com/article/200311-overview?src=mbl_msp_android&ref=share
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