Formulation and evaluation of bioadhesive buccal Films of Domperidone co-crystals by using Tamarind kernel powder as mucoadhesive polymer

  • Sailaja Rongali Assistant professor, Department of pharmaceutics, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India-53662 https://orcid.org/0009-0001-5645-826X
  • Jagadeesh Panda Principal, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662
  • Kala Jyotsna Bankuru Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662 https://orcid.org/0009-0005-8577-7701
  • Hanumanth Badri Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662 https://orcid.org/0009-0004-4405-5131
  • Manju Priya Bonela Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662 https://orcid.org/0009-0005-5341-9045
  • Bhavya Gonthupalli Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662 https://orcid.org/0009-0007-4515-3456
Keywords: cocrystals, mucoadhesive, solvent casting, modified physical balance method, buccal films

Abstract

As solubility plays key role in drug dissolution and bioavailability lots of techniques to enhance solubility are evolved. One of the techniques is co crystallization. The main aim of the work is to enhance the solubility of domperidone by co crystallization using coformers like Para amino benzoic acid and succinic acid. The cocrystals were evaluated for melting point and solubility enhancement.  these cocrystals were used to prepare buccal films by solvent casting method. In the preparation of buccal films Tamarind kernel powder obtained from the seeds of Tamarind is used as mucoadhesive polymer and Hydroxy propyl methyl cellulose as film former, Polyethylene glycol 6000 as plasticizer, dehydrated banana powder as super disintegrant, sodium saccharin as sweetener and mixture of ethanol and water as solvents. The mucoadhesive strength of Tamarind kernel powder was determined using modified physical balance method. Four buccal films were prepared in which PDBF1 and PDBF2 are the two buccal films prepared using cocrystals of domperidone and Para amino benzoic acid and other two buccal films SDBF1 and SDBF2 with cocrystals of domperidone and Succinic acid. The buccal films were evaluated for different tests like folding endurance, swelling index and Surface pH. In vitro diffusion studies were conducted by Franz diffusion cell using egg membrane as semipermeable membrane and phosphate buffer of pH 7.4. The buccal films prepared with cocrystals of domperidone and succinic acid at weight ratio 1:2 has shown 86%drug release. The work has concluded that there is fold increase in aqueous solubility of Domperidone and the optimized formula is SDBF2 and Tamarind kernel powder can be used as mucoadhesive polymer in novel drug delivery systems.

Keywords: co crystals, solvent evaporation, muco adhesive, buccal films, solvent evaporation

Downloads

Download data is not yet available.

Author Biographies

Sailaja Rongali, Assistant professor, Department of pharmaceutics, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India-53662

Assistant professor, Department of pharmaceutics, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India-53662

Jagadeesh Panda, Principal, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Principal, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Kala Jyotsna Bankuru, Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Hanumanth Badri, Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Manju Priya Bonela, Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Bhavya Gonthupalli, Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

Students, Raghu college of pharmacy, Visakhapatnam, Andhra Pradesh, India -53662

References

Peltonen L, Practical guidelines for characterization and quality control of pure drug nano particles and nano-crystals in the pharmaceutical industry, Advanced drug delivery rev, 2018;13(1):101-115. https://doi.org/10.1016/j.addr.2018.06.009 PMid:29920294

Sarfaraz Md, Sushil Kumar, Doddayya H, Fabrication and evaluation of mouth-dissolving films of domperidone, International Journal of Current Pharmaceutical research, 2023;15(2): 36-43. https://doi.org/10.22159/ijcpr.2023v15i2.2088

Thorat KV, Khade P, Kakade S,Bhosale A, Formulation and evaluation of fast dissolving mouth film of domperdone, World Journal of Pharmaceutical sciences,2021;10( 12) :2104-2121.

Khobragade DS, Goud UB, Prakash JSV, Pranav Kumar A.V.R, Reddy GRS, Potbhre M, Formulation and evaluation of polymer based, rapid onset, patient friendly, oral film of Domperidone maleate, World Journal of Pharmaceutical sciences , 2016; 4(1): 115-122.

chawanorasest K, saengtongdee P, kaemchantuek P, Extraction and characterization of Tamarind (Tamarind indica L.) Seed polysaccharides from three different sources, molecules, 2016 ;21(6): 775. https://doi.org/10.3390/molecules21060775 PMid:27314322 PMCid:PMC6274079

Pandekal MS, Tegginmat PK, Formulation and evaluation of bioadhesive patch for buccal delivery of Tizanidine, Acta pharmaceutica sinica B, 2012;2(3): 318-324. https://doi.org/10.1016/j.apsb.2011.12.012

Jassim ZE, Al-Kinani KK, Alwan ZS, Preparation and evaluation Pharmaceutical Cocrystals for Solubility Enhancement of Dextromethorphan HBr, International journal of drug delivery and technology,2021;11(4):1342-1349.

Dhakar RC, Maurya SD, Sagar BPS, Bhagat S, Prajapati SK, Jain CP, Variables influencing the drug entrapment efficiency of microspheres: A pharmaceutical review, Der Pharmacia Lettre, 2010;2(5):102-116

Natevschul thesis, Jan-dav henck. Role of co crystals in the pharmaceutical development continuum. In:Wouters J, Quere L, editors. Pharmaceutical salts and co-crystals. Cambridge: The royal society of chemistry; 2012.p.110-125. https://doi.org/10.1039/9781849733502-00110

Brittain HG. Co-crystals systems of pharmaceutical interest, Cryst growth des 2012;12(2):1046-54. https://doi.org/10.1021/cg201510n

Blagden N, de Matas M. Gavan PT, York, P crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates, Advanced Drug delivery Revison ,2007;59(7):617-630. https://doi.org/10.1016/j.addr.2007.05.011 PMid:17597252

Izutsu KI Koide T, Takata N, Ikeda Y, Ono M and Inoue M, Characterization and quality control of pharmaceutical co-crystals, Chemical and pharmaceutical bulletin, 2016 ;64(10):1421-1430. https://doi.org/10.1248/cpb.c16-00233 PMid:27319284

Douroumis, D, Ross SA, Nokhodchi A, Advanced methodologies for co-crystal synthesis. Advanced drug delivery Reviews, 2017;11(7):178-95. https://doi.org/10.1016/j.addr.2017.07.008 PMid:28712924

Stoler E. Warner JC, Non-covalent derivatives co-crystals and eutectics molecules 2015:20(8);14833-48. https://doi.org/10.3390/molecules200814833 PMid:26287141 PMCid:PMC6332263

Kotak U, Prajapati VD, Solanki HK , Jani GK Jha p, Co crystallization tech its rationale and recent progress, world Journal of Pharmaceutical sciences, 2015;(2):484-508 .

Aboutaleb A.E., Abdel-Rahman S.I., Ahmed M.O, Younis M.A, Design and evaluation of domperidone sublingual tablets, International journal of Pharmaceutical . Sciences, 2016;8:195-201.

Ali M.S., Vijendar C., Sudheer Kumar C., Krishnaveni J, Formulation and evaluation of fast dissolving oral films of diazepam. Journal of Pharmacovigiance,2016;4(3):1000210. https://doi.org/10.4172/2329-6887.1000210

Alim M., Karna S., Chaturvedi S, Agrawal V.K, Validated UV spectrophotometric method for estimation of domperidone for dissolution study, Der Pharmacia Lettre,. 2015;7:53-58.

Alipour S., Akbari S., Ahmadi F, Development and in vitro evaluation of fast-dissolving oral films of ondansetron hydrochloride, Trends in Pharmacological sciences, 2015;1:25-30

Almeida N.M.G., Lima R, Alves T.F.R, Rebelo M.A, Severino P, Chaud M.V,A novel dosage form for buccal administration of bupropion, Brazilian Journal of Pharmaceutical Sciences, 2015;51:91-100. https://doi.org/10.1590/S1984-82502015000100010

Arya A, Chandra A, Sharma V, Pathak K, Fast dissolving oral films an innovative drug delivery system and dosage form, International. Journal of ChemTech Research, 2010;2:576-583

Tong X, Pan W, Su T, et al, 2020. Recent advances in natural polymer-based drug delivery systems, Reactive & FunctionalPolymers,148;104501. https://doi.org/10.1016/j.reactfunctpolym.2020.104501

Kumar GA, Wadood SA, Maurya SD, Ramchand D, Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation, Asian Journal of Pharmaceutics-October-December 2010; 179-184 https://doi.org/10.4103/0973-8398.76738

Prasanthi N, Krishna CS, Gupta ME, Manikiran SS, Rama Rao N. "Design and Development of Sublingual Fast Dissolving Films for an Antiasthmatic Drug, Scholars Research Library, 2011.

Goel H, Rai P, Rana V, Ashok K Tiwary K, Orally disintegrting systems: Innovations in formulation and technology, Recent patents on drugdelivery and formulation, 2008; 2(3) : 258-274. https://doi.org/10.2174/187221108786241660 PMid:19075912

Srujana S, Anjamma M, Alimuddin, Singh B, Dhakar RC, Natarajan S, Hechhu R. A Comprehensive Study on the Synthesis and Characterization of TiO2 Nanoparticles Using Aloe vera Plant Extract and Their Photocatalytic Activity against MB Dye. Adsorption Science & Technology. 2022;2022 https://doi.org/10.1155/2022/7244006

Arya A, Chandra A, Sharma V, Pathak K. Fast Dissolving Oral Films: An Innovative Drug delivery System and dosage Form, International Journal of ChemTech Research, 2010;2: 576-583.

Apoorva M, Neha C, Geeta A, Formulation and characterization of fast dissolving buccal films: a review, Der Pharmacia Lettre, 2011; 3(1):152-165.

Published
2024-08-15
How to Cite
1.
Rongali S, Panda J, Bankuru KJ, Badri H, Bonela MP, Gonthupalli B. Formulation and evaluation of bioadhesive buccal Films of Domperidone co-crystals by using Tamarind kernel powder as mucoadhesive polymer. JDDT [Internet]. 15Aug.2024 [cited 8Sep.2024];14(8):123-9. Available from: https://jddtonline.info/index.php/jddt/article/view/6647