Formulation and evaluation of bioadhesive buccal Films of Domperidone co-crystals by using Tamarind kernel powder as mucoadhesive polymer
Abstract
As solubility plays key role in drug dissolution and bioavailability lots of techniques to enhance solubility are evolved. One of the techniques is co crystallization. The main aim of the work is to enhance the solubility of domperidone by co crystallization using coformers like Para amino benzoic acid and succinic acid. The cocrystals were evaluated for melting point and solubility enhancement. these cocrystals were used to prepare buccal films by solvent casting method. In the preparation of buccal films Tamarind kernel powder obtained from the seeds of Tamarind is used as mucoadhesive polymer and Hydroxy propyl methyl cellulose as film former, Polyethylene glycol 6000 as plasticizer, dehydrated banana powder as super disintegrant, sodium saccharin as sweetener and mixture of ethanol and water as solvents. The mucoadhesive strength of Tamarind kernel powder was determined using modified physical balance method. Four buccal films were prepared in which PDBF1 and PDBF2 are the two buccal films prepared using cocrystals of domperidone and Para amino benzoic acid and other two buccal films SDBF1 and SDBF2 with cocrystals of domperidone and Succinic acid. The buccal films were evaluated for different tests like folding endurance, swelling index and Surface pH. In vitro diffusion studies were conducted by Franz diffusion cell using egg membrane as semipermeable membrane and phosphate buffer of pH 7.4. The buccal films prepared with cocrystals of domperidone and succinic acid at weight ratio 1:2 has shown 86%drug release. The work has concluded that there is fold increase in aqueous solubility of Domperidone and the optimized formula is SDBF2 and Tamarind kernel powder can be used as mucoadhesive polymer in novel drug delivery systems.
Keywords: co crystals, solvent evaporation, muco adhesive, buccal films, solvent evaporation
Downloads
References
Peltonen L, Practical guidelines for characterization and quality control of pure drug nano particles and nano-crystals in the pharmaceutical industry, Advanced drug delivery rev, 2018;13(1):101-115. https://doi.org/10.1016/j.addr.2018.06.009 PMid:29920294
Sarfaraz Md, Sushil Kumar, Doddayya H, Fabrication and evaluation of mouth-dissolving films of domperidone, International Journal of Current Pharmaceutical research, 2023;15(2): 36-43. https://doi.org/10.22159/ijcpr.2023v15i2.2088
Thorat KV, Khade P, Kakade S,Bhosale A, Formulation and evaluation of fast dissolving mouth film of domperdone, World Journal of Pharmaceutical sciences,2021;10( 12) :2104-2121.
Khobragade DS, Goud UB, Prakash JSV, Pranav Kumar A.V.R, Reddy GRS, Potbhre M, Formulation and evaluation of polymer based, rapid onset, patient friendly, oral film of Domperidone maleate, World Journal of Pharmaceutical sciences , 2016; 4(1): 115-122.
chawanorasest K, saengtongdee P, kaemchantuek P, Extraction and characterization of Tamarind (Tamarind indica L.) Seed polysaccharides from three different sources, molecules, 2016 ;21(6): 775. https://doi.org/10.3390/molecules21060775 PMid:27314322 PMCid:PMC6274079
Pandekal MS, Tegginmat PK, Formulation and evaluation of bioadhesive patch for buccal delivery of Tizanidine, Acta pharmaceutica sinica B, 2012;2(3): 318-324. https://doi.org/10.1016/j.apsb.2011.12.012
Jassim ZE, Al-Kinani KK, Alwan ZS, Preparation and evaluation Pharmaceutical Cocrystals for Solubility Enhancement of Dextromethorphan HBr, International journal of drug delivery and technology,2021;11(4):1342-1349.
Dhakar RC, Maurya SD, Sagar BPS, Bhagat S, Prajapati SK, Jain CP, Variables influencing the drug entrapment efficiency of microspheres: A pharmaceutical review, Der Pharmacia Lettre, 2010;2(5):102-116
Natevschul thesis, Jan-dav henck. Role of co crystals in the pharmaceutical development continuum. In:Wouters J, Quere L, editors. Pharmaceutical salts and co-crystals. Cambridge: The royal society of chemistry; 2012.p.110-125. https://doi.org/10.1039/9781849733502-00110
Brittain HG. Co-crystals systems of pharmaceutical interest, Cryst growth des 2012;12(2):1046-54. https://doi.org/10.1021/cg201510n
Blagden N, de Matas M. Gavan PT, York, P crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates, Advanced Drug delivery Revison ,2007;59(7):617-630. https://doi.org/10.1016/j.addr.2007.05.011 PMid:17597252
Izutsu KI Koide T, Takata N, Ikeda Y, Ono M and Inoue M, Characterization and quality control of pharmaceutical co-crystals, Chemical and pharmaceutical bulletin, 2016 ;64(10):1421-1430. https://doi.org/10.1248/cpb.c16-00233 PMid:27319284
Douroumis, D, Ross SA, Nokhodchi A, Advanced methodologies for co-crystal synthesis. Advanced drug delivery Reviews, 2017;11(7):178-95. https://doi.org/10.1016/j.addr.2017.07.008 PMid:28712924
Stoler E. Warner JC, Non-covalent derivatives co-crystals and eutectics molecules 2015:20(8);14833-48. https://doi.org/10.3390/molecules200814833 PMid:26287141 PMCid:PMC6332263
Kotak U, Prajapati VD, Solanki HK , Jani GK Jha p, Co crystallization tech its rationale and recent progress, world Journal of Pharmaceutical sciences, 2015;(2):484-508 .
Aboutaleb A.E., Abdel-Rahman S.I., Ahmed M.O, Younis M.A, Design and evaluation of domperidone sublingual tablets, International journal of Pharmaceutical . Sciences, 2016;8:195-201.
Ali M.S., Vijendar C., Sudheer Kumar C., Krishnaveni J, Formulation and evaluation of fast dissolving oral films of diazepam. Journal of Pharmacovigiance,2016;4(3):1000210. https://doi.org/10.4172/2329-6887.1000210
Alim M., Karna S., Chaturvedi S, Agrawal V.K, Validated UV spectrophotometric method for estimation of domperidone for dissolution study, Der Pharmacia Lettre,. 2015;7:53-58.
Alipour S., Akbari S., Ahmadi F, Development and in vitro evaluation of fast-dissolving oral films of ondansetron hydrochloride, Trends in Pharmacological sciences, 2015;1:25-30
Almeida N.M.G., Lima R, Alves T.F.R, Rebelo M.A, Severino P, Chaud M.V,A novel dosage form for buccal administration of bupropion, Brazilian Journal of Pharmaceutical Sciences, 2015;51:91-100. https://doi.org/10.1590/S1984-82502015000100010
Arya A, Chandra A, Sharma V, Pathak K, Fast dissolving oral films an innovative drug delivery system and dosage form, International. Journal of ChemTech Research, 2010;2:576-583
Tong X, Pan W, Su T, et al, 2020. Recent advances in natural polymer-based drug delivery systems, Reactive & FunctionalPolymers,148;104501. https://doi.org/10.1016/j.reactfunctpolym.2020.104501
Kumar GA, Wadood SA, Maurya SD, Ramchand D, Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation, Asian Journal of Pharmaceutics-October-December 2010; 179-184 https://doi.org/10.4103/0973-8398.76738
Prasanthi N, Krishna CS, Gupta ME, Manikiran SS, Rama Rao N. "Design and Development of Sublingual Fast Dissolving Films for an Antiasthmatic Drug, Scholars Research Library, 2011.
Goel H, Rai P, Rana V, Ashok K Tiwary K, Orally disintegrting systems: Innovations in formulation and technology, Recent patents on drugdelivery and formulation, 2008; 2(3) : 258-274. https://doi.org/10.2174/187221108786241660 PMid:19075912
Srujana S, Anjamma M, Alimuddin, Singh B, Dhakar RC, Natarajan S, Hechhu R. A Comprehensive Study on the Synthesis and Characterization of TiO2 Nanoparticles Using Aloe vera Plant Extract and Their Photocatalytic Activity against MB Dye. Adsorption Science & Technology. 2022;2022 https://doi.org/10.1155/2022/7244006
Arya A, Chandra A, Sharma V, Pathak K. Fast Dissolving Oral Films: An Innovative Drug delivery System and dosage Form, International Journal of ChemTech Research, 2010;2: 576-583.
Apoorva M, Neha C, Geeta A, Formulation and characterization of fast dissolving buccal films: a review, Der Pharmacia Lettre, 2011; 3(1):152-165.
Copyright (c) 2024 Sailaja Rongali, Jagadeesh Panda, Kala Jyotsna Bankuru, Hanumanth Badri, Manju Priya Bonela, Bhavya Gonthupalli
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
. 