Effects of oxycodone hydrochloride on reproductive functions in male wistar rats

  • Landry Martial Miguel Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Herman Akassa Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Archange Emmanuel Mboungou Malonga Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Anne Loïs Nkanga Samba Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Destin Mbemba Bahamboula Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Choupette Ravelle Dobhat-Doukakini Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Didier Gesril NJILO TCHATCHOUANG Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Childérick Lékana Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Donatien Moukassa Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
  • Ange Antoine Abena Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
Keywords: oxycodone hydrochloide, spermatic and hormonal parameters, gonads, rat

Abstract

Drug iatrogenicity is a constantly evolving phenomenon, affecting several therapeutic classes. The aim of the present study was to investigate the effects of prolonged administration of oxycodone hydrochloride, a central analgesic, on reproductive functions in male rats. Materials and methods: three groups of 5 rats each were created; distilled water 0.5 ml/100g, oxycodone hydrochloride 5 and 10 mg/kg. The different products were administered orally daily for 30 days. The variables studied were: animal behaviour, prostate, testicular and epididymal weights, spermogram parameters and hormonal biomarkers (FSH, LH and testosterone levels).

Results: behaviorally and morphologically, the results obtained show that oxycodone hydrochloride at doses of 5 and 10 mg/kg causes stiffness of the animals' tails, priaprism and atrophy of the prostate, testicles and epididymis, of which intensity was dose-dependent. On spermogram parameters, oxycodone hydrochloride caused a significant decrease in sperm motility (p<0.001) and in the number of normal spermatozoa (p<0.05). Administration of oxycodone hydrochloride to rats significantly decreased testosterone levels (p<0.05) and an increase in LH levels.

Conclusion: Oxycodone hydrochloride, administered to animals at doses of 5 and 10 mg/kg, causes morphological disturbances of the gonads and related structures, spermogram parameters and gonadal hormones.

Keywords: oxycodone hydrochloide, spermatic and hormonal parameters, gonads, rat

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Author Biographies

Landry Martial Miguel, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Herman Akassa, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Archange Emmanuel Mboungou Malonga, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Anne Loïs Nkanga Samba, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Destin Mbemba Bahamboula, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Choupette Ravelle Dobhat-Doukakini, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Dénis Sassou-N’Guesso University, Kintélé, Republic of Congo

Didier Gesril NJILO TCHATCHOUANG, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Dénis Sassou-N’Guesso University, Kintélé, Republic of Congo

Childérick Lékana, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Dénis Sassou-N’Guesso University, Kintélé, Republic of Congo

Donatien Moukassa, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Ange Antoine Abena, Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

Dénis Sassou-N’Guesso University, Kintélé, Republic of Congo

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Published
2024-08-15
How to Cite
1.
Miguel LM, Akassa H, Mboungou Malonga AE, Nkanga Samba AL, Mbemba Bahamboula D, Dobhat-Doukakini CR, NJILO TCHATCHOUANG DG, Lékana C, Moukassa D, Abena AA. Effects of oxycodone hydrochloride on reproductive functions in male wistar rats. JDDT [Internet]. 15Aug.2024 [cited 8Sep.2024];14(8):5-. Available from: https://jddtonline.info/index.php/jddt/article/view/6643