The Evolution of Nanocrystalline Drug Delivery System

Abstract

Developing nanocrystalline drug delivery technologies is a noteworthy advancement in pharmaceutical science. The nanocrystalline formulations aim to improve therapeutic efficacy, pharmaceutical solubility, and bioavailability. We develop many methods for their fabrication, with top-down, bottom-up, and combination procedures, beginning with reasoning behind nanocrystalline approaches. In this type of review, we focused on the progress of nanocrystalline drug delivery systems in various years by applying different techniques which started in 1990 and what dosage forms are still made by this technology. It is found that various other techniques are also there manufacturing of drug Nanocrystals through years of investigation made by specialists. The researchers found methods such as Top-down, bottom-up, combination, solvent displacement technology, fluidised bed technology, freeze drying, spray drying, electrodynamic technique, and melt emulsification. Every process has advantages and disadvantages, therefore selecting the proper technology is critical to produce drug nanocrystals successfully.


Keywords: Nanocrysyals, CT, Bottom-up, Top-Down, HPH, Nanocarriers

Keywords: Nanocrysyals, CT, Bottom-up, Top-Down, HPH, Nanocarriers

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Author Biographies

Bhushan Nikumbhe, Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Rajveer Bhaskar, Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Monika Ola, Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Pratiksha Pagar, Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Prajkta Sawarkar, Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

Department of Industrial Pharmacy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule Maharashtra, India 425405.

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Nikumbhe B, Bhaskar R, Ola M, Pagar P, Sawarkar P. The Evolution of Nanocrystalline Drug Delivery System. JDDT [Internet]. 15Jun.2024 [cited 17Jul.2024];14(6):214-22. Available from: https://jddtonline.info/index.php/jddt/article/view/6628