Formulation and evaluation of sustained release floating tablets of venlafaxine using natural polymers

Authors

  • Niraj Kumar Yadav Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India
  • Nilesh Gupta Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India
  • Umesh Kumar Jain Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Abstract

Over the past three decades, oral controlled-release dosage forms have been developed due to their therapeutic advantages, such as ease of administration, patient compliance, and flexibility in formulation. However, this approach has faced physiological difficulties, such as the inability to contain and position the controlled drug delivery system within the desired region of the gastrointestinal tract (GIT) due to variable gastric emptying and motility. Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Gastroretentive dosage forms can stay in the gastric region for several hours and significantly prolong the gastric residence time of drugs. Natural materials have been extensively used in drug delivery because they are readily available, cost-effective, eco-friendly, capable of many chemical modifications, potentially degradable, and compatible due to their natural origin.

Keywords: Sustained Release Floating Tablets, Venlafaxine,

Keywords:

Sustained Release, Floating Tablets, Venlafaxine

DOI

https://doi.org/10.22270/jddt.v14i6.6611

Author Biographies

Niraj Kumar Yadav, Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Nilesh Gupta, Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Umesh Kumar Jain, Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

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Published

15-06-2024
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How to Cite

1.
Yadav NK, Gupta N, Jain UK. Formulation and evaluation of sustained release floating tablets of venlafaxine using natural polymers. J. Drug Delivery Ther. [Internet]. 2024 Jun. 15 [cited 2025 Jan. 21];14(6):125-30. Available from: https://jddtonline.info/index.php/jddt/article/view/6611

How to Cite

1.
Yadav NK, Gupta N, Jain UK. Formulation and evaluation of sustained release floating tablets of venlafaxine using natural polymers. J. Drug Delivery Ther. [Internet]. 2024 Jun. 15 [cited 2025 Jan. 21];14(6):125-30. Available from: https://jddtonline.info/index.php/jddt/article/view/6611