Formulation and evaluation of sustained release floating tablets of venlafaxine using natural polymers

  • Niraj Kumar Yadav Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India
  • Nilesh Gupta Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India
  • Umesh Kumar Jain Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Abstract

Over the past three decades, oral controlled-release dosage forms have been developed due to their therapeutic advantages, such as ease of administration, patient compliance, and flexibility in formulation. However, this approach has faced physiological difficulties, such as the inability to contain and position the controlled drug delivery system within the desired region of the gastrointestinal tract (GIT) due to variable gastric emptying and motility. Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Gastroretentive dosage forms can stay in the gastric region for several hours and significantly prolong the gastric residence time of drugs. Natural materials have been extensively used in drug delivery because they are readily available, cost-effective, eco-friendly, capable of many chemical modifications, potentially degradable, and compatible due to their natural origin.


Keywords: Sustained Release Floating Tablets, Venlafaxine,

Keywords: Sustained Release, Floating Tablets, Venlafaxine

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Author Biographies

Niraj Kumar Yadav, Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Nilesh Gupta, Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Umesh Kumar Jain, Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

Bhopal Institute of Technology and Science – Pharmacy, Bhopal, M.P., India

References

1. Singh B.N. and Kim K.H., Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release, 2000; 63: 235-259. https://doi.org/10.1016/S0168-3659(99)00204-7 PMid:10601721
2. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv. 2006; 3 (2): 217-233. https://doi.org/10.1517/17425247.3.2.217 PMid:16506949
3. Dhakar RC, Maurya SD, Aggarwal S, Kumar G, Tilak VK, Design and evaluation of SRM microspheres of metformin hydrochloride, Pharmacie Globale (IJCP), 2010;1(07);
4. Kawashima, Y., Niwa, T., Takeuchi, H., Hino, T., and Ito, Y. Preparation of multiple unit hollow microspheres (micro ballons) with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behavior (in vivo). J. Control. Rel. 1991;16: 279-290. https://doi.org/10.1016/0168-3659(91)90004-W
5. Gharti KP, Budhathoki U, Thapa P, Bhargava A. Formulation in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug. Journal of Young Pharmacists. 2012 Oct 1;4(4):201-8. https://doi.org/10.4103/0975-1483.104363 PMid:23493037 PMCid:PMC3573371
6. Fu J, Yin H, Yu X, Xie C, Jiang H, Jin Y, Sheng F. Combination of 3D printing technologies and compressed tablets for preparation of riboflavin floating tablet-in-device (TiD) systems. International journal of pharmaceutics. 2018 Oct 5;549(1-2):370-9. https://doi.org/10.1016/j.ijpharm.2018.08.011 PMid:30107218
7. Patel VF, Patel NM, Yeole PG. Studies on formulation and evaluation of ranitidine floating tablets. Indian journal of pharmaceutical sciences. 2005;67(6):703.
8. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems.Trop. J Pharm Res 2008; 7(3): 1055-66. https://doi.org/10.4314/tjpr.v7i3.14691
9. Lin X, Fu H, Hou Z, Si Y, Shan W, Yang Y. Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material. International Journal of Pharmaceutics. 2021; 15; 603:120674. https://doi.org/10.1016/j.ijpharm.2021.120674 PMid:33964341
10. Rouge N, Buri P, Voelker E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int J Pharma. 1996; 136:117-139. https://doi.org/10.1016/0378-5173(96)85200-8
11. Emara LH, Abdou AR, El-Ashmawy AA, Mursi NM. Preparation and evaluation of metronidazole sustained release floating tablets. Int J Pharm Pharm Sci. 2014;6(9):198-204.
12. Kumar PD, Rathnam G, Prakash CR, Saravanan G, Karthick V, Selvam TP. Formulation and characterization of bilayer floating tablets of ranitidine. Rasayan J. Chem. 2010;3(2):368-74.
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Yadav NK, Gupta N, Jain UK. Formulation and evaluation of sustained release floating tablets of venlafaxine using natural polymers. JDDT [Internet]. 15Jun.2024 [cited 17Jul.2024];14(6):125-30. Available from: https://jddtonline.info/index.php/jddt/article/view/6611