Investigation of the Efficacy of Zonisamide in Alcohol Induced Hepatotoxicity

  • Nilüfer Dönmezdil Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey https://orcid.org/0000-0001-5543-1762
  • Selçuk Tunik Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey
  • Fırat Aşır Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey https://orcid.org/0000-0002-6384-9146
  • Senem Çetin Duran Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey
  • Dilara Akinci Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey
  • Enis Duran Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey
  • Eda Yıldızhan Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey
  • Nurullah Peker Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey
  • Mehmet Obut Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey https://orcid.org/0000-0002-6925-4784

Abstract

Subject: This research aims to evaluate the histological changes in liver tissue induced by alcohol consumption and to assess the effectiveness of zonisamide in treating alcohol-related hepatotoxicity.


Materials and Methods: The study utilized 40 adult Wistar albino rats, divided into four groups: a control (sham), an ethanol group, a zonisamide group, and a combination of ethanol and zonisamide (ethanol+zonisamide). Each group underwent a four-day binge drinking protocol to mimic excessive alcohol intake observed in humans. Zonisamide was administered at a dose of 100 mg/kg daily. Post-treatment, the liver tissues were collected, stained with hematoxylin and eosin, and examined for histopathological changes.


Results: The control and zonisamide-only groups showed no abnormal liver or vascular alterations, indicating zonisamide's safety. In contrast, the ethanol group displayed significant liver damage, including vascular dilatation, congestion, and extensive cellular degeneration. Conversely, the ethanol+zonisamide group exhibited substantial histological improvements with noticeable reductions in vascular impairments and signs of hepatocyte regeneration, suggesting that zonisamide mitigates the detrimental effects of alcohol on the liver.


Conclusion: The study concludes that zonisamide has a protective effect against alcohol-induced liver damage. It appears to preserve the structural integrity of hepatocytes and supports cellular survival, potentially through its anti-inflammatory and antioxidant properties. These promising results advocate for further exploration of zonisamide as a therapeutic option for managing liver injuries associated with alcohol abuse. This study contributes significant insights into the therapeutic potential of zonisamide, encouraging more comprehensive investigations into its clinical applications in hepatology.


Keywords: Alcohol, Zonisamide, Hepatotoxicity

Keywords: Alcohol, Zonisamide, Hepatotoxicity

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Author Biographies

Nilüfer Dönmezdil, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Selçuk Tunik, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Fırat Aşır, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Senem Çetin Duran, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Dilara Akinci, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Enis Duran, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Eda Yıldızhan, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Nurullah Peker, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Mehmet Obut, Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır, Turkey

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Dönmezdil N, Tunik S, Aşır F, Duran S Çetin, Akinci D, Duran E, Yıldızhan E, Peker N, Obut M. Investigation of the Efficacy of Zonisamide in Alcohol Induced Hepatotoxicity. JDDT [Internet]. 15May2024 [cited 17May2024];14(5):64-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6594

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