The Impact of the Antimicrobial Stewardship Program on Antibiotic Use, Resistance Patterns, and Cost in Madinat Zayed Hospital

Authors

  • Ashraf ALakkad Department of Internal Medicine, Madinat Zayed Hospital, AL Dhafra Region, UAE https://orcid.org/0000-0002-4083-2800
  • Yazan Ayaad Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE
  • Zill Huma Hussain Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE
  • Egbal Mohmed Suleimen Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE
  • Anas Alhomran Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE
  • Hesham Abdalla Department of Internal Medicine, Madinat Zayed Hospital, AL Dhafra Region, UAE

Abstract

Antimicrobial resistance and excessive antibiotic usage are a growing public health concern. Antimicrobial Stewardship Programs (ASPs) aim to optimize antibiotic use and curb resistance. This retro-respective study evaluated the impact of an ASP at Madinat Zayed Hospital, Abu Dhabi (January 2021-December 2022). It analyzed electronic health records to assess the ASP's impact on antibiotic consumption, resistance patterns, and economic outcomes. Patients from intensive care units, medical wards, and outpatient settings were included, though patients admitted to obstetrics/gynaecology, paediatrics, neonatal intensive care, and surgical wards were excluded. The primary objective of this study was to report on the ASP experience and measure the prescribing appropriateness percentage of empirical antibiotic therapy along with the de-escalation of broad-spectrum antimicrobials, after ASP implementation at Madinat Zayed Hospital in Al Dhafra Region, United Arab Emirates. The secondary objectives were to reflect on the rate of Multidrug-Resistant Organisms (MDROs), total utilization using defined daily dose, and the total direct cost of antibiotics. Descriptive analysis, proportions, mean values, and percentage changes were employed for data analysis. The ASP achieved high compliance rates with restricted antibiotics (>90%) and approved guidelines (inpatient 97-100%, outpatient 93-98%). Antibiotic de-escalation rates were also high (>80%).  Significant reductions in use were observed for cefixime (91.3%), levofloxacin (46.3%), and several others. Notably, cefepime use increased (1137.5%). Direct antibiotic expenditure decreased by 2% (saving Dhs2.6 million), and resistance decreased in some bacteria. However, a concerning rise in ceftazidime resistance against Pseudomonas aeruginosa was identified. This study concluded that the implementation of a new Antimicrobial Stewardship Program at Madinat Zayed Hospital demonstrated effectiveness in promoting responsible antibiotic use. The program achieved high compliance with restricted antibiotic use and approved guidelines, leading to significant reductions in overall antibiotic consumption.

Keywords: Antimicrobial, resistance, Multidrug-Resistant Organisms, de-escalation, consumption

Keywords:

Antimicrobial, resistance, Multidrug-Resistant Organisms, de-escalation, consumption

DOI

https://doi.org/10.22270/jddt.v14i6.6553

Author Biographies

Ashraf ALakkad, Department of Internal Medicine, Madinat Zayed Hospital, AL Dhafra Region, UAE

Department of Internal Medicine, Madinat Zayed Hospital, AL Dhafra Region, UAE

Yazan Ayaad, Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Zill Huma Hussain, Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Egbal Mohmed Suleimen, Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Anas Alhomran, Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Department of Pharmacy, Madinat Zayed Hospital, AL Dhafra Region, UAE

Hesham Abdalla, Department of Internal Medicine, Madinat Zayed Hospital, AL Dhafra Region, UAE

Department of Internal Medicine, Madinat Zayed Hospital, AL Dhafra Region, UAE

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Published

15-06-2024
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How to Cite

1.
ALakkad A, Ayaad Y, Hussain ZH, Suleimen EM, Alhomran A, Abdalla H. The Impact of the Antimicrobial Stewardship Program on Antibiotic Use, Resistance Patterns, and Cost in Madinat Zayed Hospital. J. Drug Delivery Ther. [Internet]. 2024 Jun. 15 [cited 2025 Feb. 19];14(6):51-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6553

How to Cite

1.
ALakkad A, Ayaad Y, Hussain ZH, Suleimen EM, Alhomran A, Abdalla H. The Impact of the Antimicrobial Stewardship Program on Antibiotic Use, Resistance Patterns, and Cost in Madinat Zayed Hospital. J. Drug Delivery Ther. [Internet]. 2024 Jun. 15 [cited 2025 Feb. 19];14(6):51-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6553

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