Formulation Development of Medicated Chewing Gum by Direct Compression utilizing the SeDeM Diagram Expert System

Authors

Abstract

The main objective of this study was to prepare and characterize the MCG of Ondan HCl which helps to improve the effectivity of the drug and to investigate the applicability of the SeDeM system for the formulation of MCG. The Ondan HCl was formulated into directly compressed MCG utilizing the SeDeM Diagram Expert System. The MCG was optimized using 32 factorial design. Performance evaluation was carried out by evaluating different parameters. Statistical analysis showed that micromeritic properties were improved after inclusion of appropriate excipient in optimum amount. In-vitro drug release study showed 90.01% drug release whereas ex vivo buccal permeation study exhibited significant drug permeation within 15 min indicating its potential for increasing bioavailability. It was concluded that various characteristics of powder material at pre formulation level can be successfully predicted by SeDeM diagram expert system. The developed medicated chewing gum is more effective than mouth dissolving and conventional tablet formulation.

Keywords: Ondansetron HCl; Medicated chewing gum; direct compression; SeDeM diagram expert system.

Keywords:

Ondansetron HCl, Medicated chewing gum, direct compression, SeDeM diagram expert system

DOI

https://doi.org/10.22270/jddt.v14i4.6545

Author Biographies

Preeti Gajendra Karade, Appasaheb Birnale College of Pharmacy Sangli

Appasaheb Birnale College of Pharmacy, Sangli, India

Sonal Jadhav (Mali), Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India

Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India

Rohit Ramesh Shah, Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India

Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India

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Published

15-04-2024
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How to Cite

1.
Karade PG, Jadhav (Mali) S, Shah RR. Formulation Development of Medicated Chewing Gum by Direct Compression utilizing the SeDeM Diagram Expert System. J. Drug Delivery Ther. [Internet]. 2024 Apr. 15 [cited 2025 Feb. 13];14(4):59-68. Available from: https://jddtonline.info/index.php/jddt/article/view/6545

How to Cite

1.
Karade PG, Jadhav (Mali) S, Shah RR. Formulation Development of Medicated Chewing Gum by Direct Compression utilizing the SeDeM Diagram Expert System. J. Drug Delivery Ther. [Internet]. 2024 Apr. 15 [cited 2025 Feb. 13];14(4):59-68. Available from: https://jddtonline.info/index.php/jddt/article/view/6545