Platelet-Rich Plasma Therapy for Chronic Low Back Pain with Neuropathic Component in a Pain Medicine Clinic in Mexico: Retrospective Study

Authors

Abstract

Introduction: Low back pain is a common problem affecting millions worldwide. Even after surgical treatment some patients do not improve; others suffer from persistent radiculopathy. We define Complex Chronic Low Back Pain (CCLBP) as any low back pain that has lasted for at least three months and has at least two triggering pain mechanisms. Objective: To describe our experience with platelet-rich plasma (PRP) therapy in managing CCLBP with a neuropathic component Methods: Quantitative, retrospective analysis from 57 medical records of patients treated with PRP for CCLBP. We used IBM-SPSS 21 to obtain descriptive statistics, Chi-square, Student T and Odds-Ratio. Results: The mean age of our sample was 59.8 (±14.4) years, with 6.51 (±8.7) years of pain and a follow-up of 9 (±12.2) months. 33.3% had lumbar surgery, 29.8% had lumbar trauma, 31.6% used a walking aid, 56.7% had MODIC changes on MRI, and 42% of them received intraosseous-PRP technic. 84.2% reported severe pain (VAS 8-10). The results showed that 96.5% of patients experienced some improvement after PRP treatment. Additionally, 10.5% experienced pain suppression. No significant differences in age, lumbar trauma, lumbar surgery, diseases, or the use of walking aids between patients who benefited from PRP treatment and those who did not. VAS after treatment shows significance (p<0.01) with 5.36±2.6 points. Subjects with less than five years of radicular pain had an improvement greater than 3 points on VAS (OR 7.38, IC95% 1.72-31.7). Conclusion: Autologous platelet-rich plasma injections for chronic low back pain with a neuropathic component are an effective alternative to address CCLBP’s current challenge. New studies with greater statistical power are necessary to make a statement of efficacy, but with the data obtained, it seems a promising option.

Keywords: Platelet-Rich Plasma, Low Back Pain, Radiculopathy, Intraosseous

Keywords:

Platelet-Rich Plasma, Low Back Pain, Radiculopathy, Intraosseous

DOI

https://doi.org/10.22270/jddt.v14i4.6541

Author Biographies

César Amescua-García, Algologist, Hospital Ángeles Tijuana, México

Algologist, Hospital Ángeles Tijuana, México

María del Rocío Guillén-Núñez, Algologist, Hospital Ángeles Tijuana, México

Algologist, Hospital Ángeles Tijuana, México

Alfredo Martínez-Alvarado, MPH, Hospital Ángeles Tijuana, México

MPH, Hospital Ángeles Tijuana, México

Fernando Izquierdo-Moncayo, Orthopedist, Hospital Ángeles Tijuana, México

Orthopedist, Hospital Ángeles Tijuana, México

Luis Rujana-Galaviz, Interventional algologist, Hospital Ángeles Tijuana, México

Interventional algologist, Hospital Ángeles Tijuana, México

Daniela Hernández-Rodríguez, Algologist, Hospital Ángeles Tijuana, México

Algologist, Hospital Ángeles Tijuana, México

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Published

15-04-2024
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How to Cite

1.
Amescua-García C, Guillén-Núñez M del R, Martínez-Alvarado A, Izquierdo-Moncayo F, Rujana-Galaviz L, Hernández-Rodríguez D. Platelet-Rich Plasma Therapy for Chronic Low Back Pain with Neuropathic Component in a Pain Medicine Clinic in Mexico: Retrospective Study. J. Drug Delivery Ther. [Internet]. 2024 Apr. 15 [cited 2025 Feb. 13];14(4):165-9. Available from: https://jddtonline.info/index.php/jddt/article/view/6541

How to Cite

1.
Amescua-García C, Guillén-Núñez M del R, Martínez-Alvarado A, Izquierdo-Moncayo F, Rujana-Galaviz L, Hernández-Rodríguez D. Platelet-Rich Plasma Therapy for Chronic Low Back Pain with Neuropathic Component in a Pain Medicine Clinic in Mexico: Retrospective Study. J. Drug Delivery Ther. [Internet]. 2024 Apr. 15 [cited 2025 Feb. 13];14(4):165-9. Available from: https://jddtonline.info/index.php/jddt/article/view/6541

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