Evaluation of Some Hormones Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women attending the gynecology Clinic at Nnewi

Hormones, Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women

Authors

  • Augustine Chinedu Ihim Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria; https://orcid.org/0000-0001-9991-0714
  • Charles Chinedum Onyenekwe Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;
  • Nkiruka Nwamaka Eze Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria; https://orcid.org/0009-0008-4028-2205
  • Patrick Chinedu Obi Department of Internal Medicine, Federal University Teaching Hospital Owerri, Imo State, Nigeria. https://orcid.org/0000-0003-2218-9206
  • Nosakhare Osakue Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria; https://orcid.org/0000-0002-3964-5223
  • Joseph Chimezie Awalu Department of Medical Laboratory Science, Evangel Akaeze Ebonyi State, Nigeria https://orcid.org/0000-0001-9457-8249
  • Tochukwu Anthony Ikwelle Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria; https://orcid.org/0009-0007-0014-8637

Abstract

Polycystic ovarian syndrome (PCOS), marked by oxidative stress and hormonal imbalances, causes infertility, insulin resistance, and diverse health problems. It not only affects physical health but also can strain marriages and lead to divorce, posing a notable societal issue. The levels of hormones (Estradiol (E2), Dihydroepiandrosterone sulfate (DHEA), luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (PROG) Testosterone (TEST)), total antioxidant capacity (TAC) and Malondialdehyde (MDA) in PCOS Women attending the gynecology Clinic at Nnewi were investigated. This cross-sectional study had 45 participants with PCOS as a test group and 45 participants without PCOS as the control group between the ages of 18-50 recruited. All the biochemical parameters were determined by enzyme-linked immunoassay technique. Data was expressed as Mean ± standard deviation. The differences in parameters studied between the PCOS group (test) and the control group were evaluated using an independent t-test. Statistical significance was set at p-value < 0.05. Result showed significant higher differences in the mean serum levels of DHEA (87.40±65.90), LH (34.7±36.1), FSH (19.61±14.73) and Testosterone (3.04±1.36) in women with PCOS compared with the control (1.035±0.54),( 20.76±18.1), (13.2±10.19), and (3.04±1.36)(p< 0.05) respectively. A higher significant difference exists in the mean serum MDA values of the test group (women with PCOS compared with the control group(p<0.05). This study concluded that oxidative stress and hormone imbalance occurred among participants with PCOS attending the gynecology clinic of Nnamdi Azikiwe University Teaching Hospital in Nnewi. 

Keywords: PCOS, Estradiol, DHEA, luteinizing hormone, FSH, progesterone, Testosterone, TAC

Keywords:

PCOS, Estradiol , DHEA , luteinizing hormone , FSH, progesterone, Testosterone, TAC

DOI

https://doi.org/10.22270/jddt.v14i5.6539

Author Biographies

Augustine Chinedu Ihim, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Charles Chinedum Onyenekwe, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Nkiruka Nwamaka Eze, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Patrick Chinedu Obi, Department of Internal Medicine, Federal University Teaching Hospital Owerri, Imo State, Nigeria.

Department of Internal Medicine, Federal University Teaching Hospital Owerri, Imo State, Nigeria.

Nosakhare Osakue, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Joseph Chimezie Awalu, Department of Medical Laboratory Science, Evangel Akaeze Ebonyi State, Nigeria

Department of Medical Laboratory Science, Evangel Akaeze Ebonyi State, Nigeria

Tochukwu Anthony Ikwelle, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka Anambra, Nigeria;

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Published

15-05-2024
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How to Cite

1.
Ihim AC, Onyenekwe CC, Eze NN, Obi PC, Osakue N, Awalu JC, et al. Evaluation of Some Hormones Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women attending the gynecology Clinic at Nnewi: Hormones, Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women. J. Drug Delivery Ther. [Internet]. 2024 May 15 [cited 2025 Jan. 17];14(5):108-12. Available from: https://jddtonline.info/index.php/jddt/article/view/6539

How to Cite

1.
Ihim AC, Onyenekwe CC, Eze NN, Obi PC, Osakue N, Awalu JC, et al. Evaluation of Some Hormones Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women attending the gynecology Clinic at Nnewi: Hormones, Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women. J. Drug Delivery Ther. [Internet]. 2024 May 15 [cited 2025 Jan. 17];14(5):108-12. Available from: https://jddtonline.info/index.php/jddt/article/view/6539

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