Exploring the Neuroprotective Effects of Intermittent Fasting: A Comprehensive Review on its Impact on Neurological Diseases

  • Marudhachalam jeevitha Department of Pharmacy Practice*, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India
  • R Shanmuga Sundhram Department of Pharmacology, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India
  • R Sambath Kumar Department of Pharmaceutics, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India


Background: Intermittent fasting has various benefits for brain health, owing to the physiological alterations occurring in the human body during intervals of fasting. Fasting induces a metabolic condition that improves neuronal bioenergetics, plasticity, and resilience, potentially counteracting a variety of neurological disorders.

Objectives: In the current research, we reveal the impact of IF (Intermittent Fasting)on neurological diseases.

Methodology: A literature review was conducted to create recent studies on how IF impacts neurological illnesses, including neurodegenerative diseases and Central Nervous System (CNS) disorders.

Results: Fasting decreases the production of inflammatory mediators including homocysteine, IL6, and C-reactive protein which could reduce the creation of plaques that lead to atherosclerosis, which is the primary cause of stroke in individuals. IF and ketogenic diets involve significant mechanisms, including enhanced beta-hydroxybutyrate, that have been linked with improved seizure management in certain studies, as well as the induction of other systems that work together to sustain synaptic activity. IF may also improve health and QoL (Quality Of Life)  for those who have relapsing-remitting Multiple Sclerosis. IF could prove to be a beneficial dietary treatment for the prevention and/or deceleration of dementia progression.

Conclusion: The creation of a self-empowering, affordable, and effective treatment alternative for a range of neurological issues in a time of rising medical costs and a rise in neurological diseases. In the future, if these studies are given priority, fasting regimens will be advised in addition to medication-based strategies, leading to the development of a single metabolic strategy that can alter the course and symptoms of the most prevalent and impairing neurological disorders that currently exist.

Keywords: Intermittent Fasting, Neurological disease, Brain health.

Keywords: Intermittent Fasting, Neurological disease, Brain health


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Author Biographies

Marudhachalam jeevitha, Department of Pharmacy Practice*, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

Department of Pharmacy Practice*, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

R Shanmuga Sundhram, Department of Pharmacology, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

Department of Pharmacology, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

R Sambath Kumar, Department of Pharmaceutics, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India

Department of Pharmaceutics, J.K.K.Nattraja College of Pharmacy, Kumarapalayam-638183, Tamil Nadu, India


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jeevitha M, Shanmuga Sundhram R, Sambath Kumar R. Exploring the Neuroprotective Effects of Intermittent Fasting: A Comprehensive Review on its Impact on Neurological Diseases. JDDT [Internet]. 15Mar.2024 [cited 19Apr.2024];14(3):174-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6486