Formulation and Evaluation of Moxifloxacin Hydrochloride Loaded Cubosomal Gel for Ocular Delivery

  • A Bhageerathy Associate Professor, Department of Pharmaceutics, Mount Zion College of Pharmaceutical Sciences and Research. Chayalode PO Ezhamkulam, Adoor, Pathanamthitta, Kerala – 691556, India. https://orcid.org/0009-0000-1971-5995
  • V V Prasanth Professor, Department of Pharmaceutics, Mount Zion College of Pharmaceutical Sciences and Research. Chayalode PO Ezhamkulam, Adoor, Pathanamthitta, Kerala – 691556, India.

Abstract

This study aimed to develop and evaluate an ocular, prolonged-release cubogel formulation of moxifloxacin hydrochloride (MX) to treat conjunctivitis. Using glycerol monooleate and poloxamer 407 in varying concentrations, a cubosome containing the antibiotic MX was developed using a top-down approach. Further, by dispersing optimized cubosomes in a cold in-situ gelling system, MX cubogels were prepared.  Following Higuchi's release kinetic model, formulations MA4, MA8, MA11, and MA14 released 95.84, 95.77, 97.45, and 97.68% of MX after 12 hours. The in-vitro corneal permeation study showed that the goat cornea absorbed 81% of MX cubogel than conventional formulations. From the results of antibacterial and histopathological studies, the selected formulations were safe for ocular administration. This study concluded that MX cubogel may be a suitable alternative to conventional eye drops due to its increased permeability and sustained release characteristics.


Keywords: Conjunctivitis, Cubosome, Glycerol monooleate, Moxifloxacin hydrochloride Poloxamer 407

Keywords: Conjunctivitis, Cubosome, Glycerol monooleate, Moxifloxacin hydrochloride, oloxamer 407

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Author Biographies

A Bhageerathy, Associate Professor, Department of Pharmaceutics, Mount Zion College of Pharmaceutical Sciences and Research. Chayalode PO Ezhamkulam, Adoor, Pathanamthitta, Kerala – 691556, India.

Research Scholar, Department of Pharmaceutical Science, Shri Jagdishprasad Jhabarmal Tibrewala University, Rajasthan, India.

V V Prasanth, Professor, Department of Pharmaceutics, Mount Zion College of Pharmaceutical Sciences and Research. Chayalode PO Ezhamkulam, Adoor, Pathanamthitta, Kerala – 691556, India.

Professor, Department of Pharmaceutics, Mount Zion College of Pharmaceutical Sciences and Research. Chayalode PO Ezhamkulam, Adoor, Pathanamthitta, Kerala – 691556, India.

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Bhageerathy A, Prasanth VV. Formulation and Evaluation of Moxifloxacin Hydrochloride Loaded Cubosomal Gel for Ocular Delivery. JDDT [Internet]. 15Mar.2024 [cited 19Apr.2024];14(3):88-9. Available from: https://jddtonline.info/index.php/jddt/article/view/6464