Formulation and Evaluation of Pulsatile drug delivery of Albuterol sulphate and Theophylline drugs using modified Pulsincap technology

Authors

  • Govinda Reddy G. Research Scholar, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan
  • Rakesh Kumar Jat Research Guide, Professor, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan
  • K M Manjanna Research Co Guide Professor, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

Abstract

Albuterol Sulphate and Theophylline are used as anti-asthma agents. The objective of the present investigation was to design develop and evaluate a modified pulsincap drug delivery system of Albuterol Sulphate and Theophylline for the treatment of Asthma. The body of capsule was made insoluble with water by cross linking with formaldehyde. This modified capsule was completely filled with drug with polymer such as HPMCK15M, HPMC K 100M, PVPK-30 to expel the drug after predetermined lag time. A hydrogel plug was inserted in the body of a capsule to obtain desired drug release after a lag time for chronotherapy of asthma. Untreated capsule was attached to the treated body and was released. The drug was exerted to precompression parameter such as Angle of repose, Bulk density, Tapped density, Car’s index Hassner’s ratio. These capsules were subjected to further post formulation studies such as weight variation, drug content, invitro dissolution studies separately. The pre and post formulation parameters were found to be within permissible limit. The mere compatibility of drug, polymer and excipients were determined by Fourier transform infrared analysis (FTIR) and UV-Visible spectroscopy (UV). The results showed that drug was completely compatible with polymer and excipients. In vitro dissolution were carried out by using pH 6 .8 and pH 7.4 buffers. Based on the result obtained F5 Formulation shows good dissolution profile. Higuchi, Hixson crowell. Koresmeyer peppas to evaluate the kinetics and drug release. The drug release follows first order kinetics and the mechanism was found to be NON FICKS DIFFUSION.

Keywords: Albuterol Sulphate, Theophylline, modified pulsincap drug delivery system, FTIR, Dissolution

Keywords:

Albuterol Sulphate, Theophylline, modified pulsincap drug delivery system, FTIR, Dissolution

DOI

https://doi.org/10.22270/jddt.v14i2.6383

Author Biographies

Govinda Reddy G., Research Scholar, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

Research Scholar, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

Rakesh Kumar Jat, Research Guide, Professor, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

Research Guide, Professor, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

K M Manjanna, Research Co Guide Professor, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

Research Co Guide  Professor, Institute of Pharmacy, Shri JJT University, Jhunjhunu, Rajasthan

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Published

15-02-2024
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How to Cite

1.
Reddy G. G, Jat RK, Manjanna KM. Formulation and Evaluation of Pulsatile drug delivery of Albuterol sulphate and Theophylline drugs using modified Pulsincap technology. J. Drug Delivery Ther. [Internet]. 2024 Feb. 15 [cited 2025 Feb. 19];14(2):127-33. Available from: https://jddtonline.info/index.php/jddt/article/view/6383

How to Cite

1.
Reddy G. G, Jat RK, Manjanna KM. Formulation and Evaluation of Pulsatile drug delivery of Albuterol sulphate and Theophylline drugs using modified Pulsincap technology. J. Drug Delivery Ther. [Internet]. 2024 Feb. 15 [cited 2025 Feb. 19];14(2):127-33. Available from: https://jddtonline.info/index.php/jddt/article/view/6383

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