Formulation and In Vitro Evaluation of Niosomal Gel for The Topical Administration of Losartan Potassium

  • Ruthika Ratna Veni Marri Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India
  • Mandati Nithisha Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India
  • Mamidipalli Apurva Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India
  • Raghavarapu Prasanthi Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India
  • Tirunagari Mamatha Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Abstract

This study aims to develop and test a topical drug delivery system for antihypertensive activity using Losartan potassium-loaded niosomes. The niosomes were created using the traditional ether injection approach, with four formulations made using cholesterol as the lipid and varying quantities of surfactants such as span 80 and span 60. The different formulations underwent testing for FTIR, particle size, zeta potential, drug content, entrapment efficiency, and in vitro release. FTIR analysis revealed that the medication was incompatible with excipients. The study concludes by highlighting current obstacles and future possibilities for the development of niosomes as effective vehicles. Overall, this analysis provides insight into the potential of niosomes in medication delivery and encourages further research in this field.


Keywords: Losartan potassium, Antihypertensive, Niosomes, Tween 80 and Span 20

Keywords: Losartan potassium, Antihypertensive, Niosomes, Tween 80, Span 20

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Author Biographies

Ruthika Ratna Veni Marri, Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Mandati Nithisha, Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Mamidipalli Apurva, Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Raghavarapu Prasanthi, Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Tirunagari Mamatha, Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

Department of Pharmaceutical Quality Assurance, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Secunderabad, Telangana, India

References

1. Aparajay, P.; Dev, A. Functionalised Niosomes as a Smart Delivery Device in Cancer and Fungal Infection. Eur. J. Pharm. Sci. 2022; 168:106052. https://doi.org/10.1016/j.ejps.2021.106052 PMid:34740786
2. Pawar, S. D.; Pawar, R. G.; Kodag, P. P.; Waghmare, A. S.; Gadhave, M. V.; Jadhav, S. L.; Gaikwad, D. D. Niosomes:a Novel Drug Delivery. IJBPAS 2012; 1 (3):406-416.
3. Baillie, A. J.; Coombs, G. H.; Dolan, T. F.; Laurie, J. Nonionic Surfactant Vesicles Niosomes as Delivery System for the Anti-leishmanial Drug Sodium Stilbogluconate. J. Pharm. Pharmacol. 1986; 38 (4):502-505. https://doi.org/10.1111/j.2042-7158.1986.tb04623.x PMid:2875149
4. Bini, K. B.; Akhilesh, D.; Prabhakar, P. Development and Characterization of NonIonic Surfactant Vesicles (Niosomes) for Oral Delivery of Lornoxicam. Int. J. Drug Dev. Res. 2012; 4(3):147-154.
5. Rogerson, A.; Cummings, J.; Willmott, N.; Florence, A. T. The Distribution of Doxorubicin in Mice Following Administration in Niosomes. J. Pharm. Pharmacol. 1988; 40(5):337-342. https://doi.org/10.1111/j.2042-7158.1988.tb05263.x PMid:2899629
6. Biju, S. S.; Talegaonkar, S.; Misra, P. R.; Khar, R. K. Vesicular Systems: An Overview. Indian J. Pharm. Sci. 2006; 68(4):141-153. https://doi.org/10.4103/0250-474X.25707
7. Chen, S.; Hanning, S.; Falconer, J.; Locke, M.; Wen, J. Recent Advances in Non-ionic Surfactant Vesicles(Niosomes): Fabrication, Characterization, Pharmaceutical and Cosmetic Applications. Eur. J. Pharm. Biopharm. 2019; 144:18-39. https://doi.org/10.1016/j.ejpb.2019.08.015 PMid:31446046
8. Gieringer, D. H. The Safety and Efficacy of New Drug Approval. Cato J. 1985; 5 (1):177-201.
9. Masjedi, M.; Montahaei, T. An Illustration Review on Nonionic Surfactant Vesicles (Niosomes) as an Approach in Modern Drug Delivery: Fabrication, Characterization, Pharmaceutical and Cosmetic Applications. J. Drug Deliv. Sci. Technol. 2021; 15:102234. https://doi.org/10.1016/j.jddst.2020.102234
10. Verma, S.; Singh, S. K.; Navneet, S.; Mathur, P.; Valecha, V. Nanoparticle Vesicular Systems: A Versatile Tool for Drug Delivery. J. Chem. Pharm. Res. 2010; 2(5):496-509.
11. Mahale, N. B.; Thakkar, P. D.; al Mali, R. G.; Walunj, D. R.; Chaudhari, S. R. Niosomes: Novel Sustained Release Non Ionic Stable Vesicular Systems- An Overview. Adv. Colloid Interface Sci. 2012; 183-184:46-54. https://doi.org/10.1016/j.cis.2012.08.002 PMid:22947187
12. Nasseri, B.; Florence, A. T. Some Properties of Extruded Nonionic Surfactant Micro-tubes. Int. J. Pharm. 2003; 254(1):11-16. https://doi.org/10.1016/S0378-5173(02)00669-5 PMid:12615401
13. Nayak, A. S.; Chodisetti, S. G.; Gadag, S.; Nayak, U. Y.; Govindan, S.; Raval, K. Tailoring Solulan C24 Based Niosomes for Transdermal Delivery of Donepezil: In Vitro Characterization, Evaluation of pH Sensitivity and Microneedle-Assisted Ex Vivo Permeation Studies. J. Drug Deliv. Sci. Technol. 2020; 60:101945. https://doi.org/10.1016/j.jddst.2020.101945
14. Rasul, A.; Imran Khan, M.; Ur Rehman, M.; Abbas, G.; Aslam, N.; Ahmad, S.; Abbas, K.; Akhtar Shah, P.; Iqbal, M.; Ahmed Al Subari, A. M.; Shaheer, T.; Shah, S. In Vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug. Int. J. Nanomedicine 2020; 15:7937-7949. https://doi.org/10.2147/IJN.S268846 PMid:33116510 PMCid:PMC7569247
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1.
Marri RRV, Nithisha M, Apurva M, Prasanthi R, Mamatha T. Formulation and In Vitro Evaluation of Niosomal Gel for The Topical Administration of Losartan Potassium. JDDT [Internet]. 15Jan.2024 [cited 25Feb.2024];14(1):41-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6366