Phytochemical investigation and evaluation of antihyperglycemic activity of Praecitrullus fistulosus fruits

Authors

  • Shivani Singh Senger Dr. A. P. J. Abdul Kalam Technical University, Vistar Yojna, AKTU CDRI Rd, Naya Khera, Jankipuram, Lucknow, UP, 226031
  • Anjali Singh Aryan College of Pharmacy, Ghaziabad, UP, 201002
  • Megha Jha Manager (R&D), Pinnacle Biomedical Research Institute (PBRI), Near, Bharat Scout and Guides Campus, Shanti Marg, Shyamla Hills Road, Depot Chouraha, Bhopal, MP, 462003
  • Deepak Kumar Jain Chetana College of Pharmacy, Infront of New Police Station, RLM Campus, Rithore, Khurai, Dist-Sagar, MP, 470117 https://orcid.org/0000-0001-9139-7717

Abstract

Diabetes mellitus [antihyperglycemic] is the endocrine metabolic disorder characterized by raised glucose level in the sanguine liquid of body i.e. blood serum due to disturbance of carbohydrate metabolism. In Diabetes mellitus extent of glucose is maintained by well know endocrine pancreatic secreted hormone fuel called insulin which help in metabolizing the glucose level by muscular utilization and other organ pathological activity. When the levels of insulin fall below the body desire it can to hyperglycemic condition. Antihyperglycemic therapeutic plant has an ability to restore abnormal pancreatic condition by increase of insulin, enhancement of body carbohydrate utilization. There are more than 400 reported plant species used an antihyperglycemic and antihyperlipidemic. Praecitrullus fistulosus is reported to contain polyphenols, flavonoids, ascorbic acid, tannin, alkaloid, saponin, phytosterol, diterpines, thiamin, and carotene that possess antidiabetic, antioxidative and anthelmintic activity. On investigation and understanding the cause of diabetes mellitus, had opened the large view for the treatment. Phytomedicine has considerably taken the prominent position for the treatment of many metabolic disorders. Biochemical studies concluded that Praecitrullus fistulosus  extract shows alteration in blood glucose level and also Praecitrullus fistulosus improved the lipid profile and showed positive aspect on different parameter in diabetic control rats and it was noted that Praecitrullus fistulosus drug extract was effective and helped in controlling the BG level in Albino Wistar Rat Praecitrullus fistulosus is reported to contain polyphenols, flavonoids, ascorbic acid, tannin, alkaloid, saponin, Phytosterol, diterpines, thiamin, and carotene that possess antidiabetic, antioxidative properties. The aim of research is to evaluate and investigate the anti-hyperglycemic activity of Praecitrullus fistulosus fruit extract on Streptozotocin (STZ)-Nicotinamide induced diabetic rat.

Keywords:  Antihyperglycemic, Praecitrullus fistulosus, Phytochemicals, Phytomedicine

Keywords:

Antihyperglycemic, Praecitrullus fistulosus, Phytochemicals, Phytomedicine

DOI

https://doi.org/10.22270/jddt.v14i2.6332

Author Biographies

Shivani Singh Senger, Dr. A. P. J. Abdul Kalam Technical University, Vistar Yojna, AKTU CDRI Rd, Naya Khera, Jankipuram, Lucknow, UP, 226031

Dr. A. P. J. Abdul Kalam Technical University, Vistar Yojna, AKTU CDRI Rd, Naya Khera, Jankipuram, Lucknow, UP, 226031

Anjali Singh, Aryan College of Pharmacy, Ghaziabad, UP, 201002

Aryan College of Pharmacy, Ghaziabad, UP, 201002

Megha Jha, Manager (R&D), Pinnacle Biomedical Research Institute (PBRI), Near, Bharat Scout and Guides Campus, Shanti Marg, Shyamla Hills Road, Depot Chouraha, Bhopal, MP, 462003

Manager (R&D), Pinnacle Biomedical Research Institute (PBRI), Near, Bharat Scout and Guides Campus, Shanti Marg, Shyamla Hills Road, Depot Chouraha, Bhopal, MP, 462003

Deepak Kumar Jain, Chetana College of Pharmacy, Infront of New Police Station, RLM Campus, Rithore, Khurai, Dist-Sagar, MP, 470117

Chetana College of Pharmacy, Infront of New Police Station, RLM Campus, Rithore, Khurai, Dist-Sagar, MP, 470117

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Published

15-02-2024
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How to Cite

1.
Senger SS, Singh A, Jha M, Jain DK. Phytochemical investigation and evaluation of antihyperglycemic activity of Praecitrullus fistulosus fruits. J. Drug Delivery Ther. [Internet]. 2024 Feb. 15 [cited 2025 Feb. 18];14(2):66-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6332

How to Cite

1.
Senger SS, Singh A, Jha M, Jain DK. Phytochemical investigation and evaluation of antihyperglycemic activity of Praecitrullus fistulosus fruits. J. Drug Delivery Ther. [Internet]. 2024 Feb. 15 [cited 2025 Feb. 18];14(2):66-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6332

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