Experimental animal models for gastric ulcer / peptic ulcer: An overview

  • Trilochan Satapathy Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India
  • Kalpana Sen Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India
  • Shailesh Sahu Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India
  • Bharti Pradhan Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India
  • Ayushi Gupta Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India
  • Md. Altaf Khan Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India
  • Dheeraj Kumar University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India
  • Abinash Satapathy College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, C.G.
  • Neha Yadav College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, C.G.

Abstract

In the present study we have discussed around sixteen different animal models used worldwide for the scientific research and new drug discovery.  The main aim of the using experimental animal models in drug discovery is to establish and provide evidence for non-clinical 'proof-of-concept' for the safety, efficacy, and target of interest for specific drug molecules. Experimental preparations developed in one species for the purpose of studying phenomena occurring in another species. The use of experimental animal models serves to better understand the origins, pathology, and the overall nature of comparable diseases of humans being. Similarly, animal models perform duties for in the development of safe and effective treatments and cures of such diseases and/or associated symptoms. Experimental animal models for drug discovery and development have played a major role in the characterization of the pathophysiology of diseases and associated mechanisms of injury, drug target identification, and evaluation of novel therapeutic agents for toxicity, pharmacokinetics and pharmacodynamics activity. Through animal model researchers can perform experiments that would be impractical or ethically prohibited with humans. There are various animal models used for screening of uncountable therapeutic activities, in this review our main focus is animal models used for peptic ulcer. Peptic ulcer is one of the worldwide diseases where 10% of adults are affected by peptic ulcer once in their lifetime. The antiulcer models for drug development against gastric and duodenal ulcer studies are limited in number that has hindered the progress of targeted therapy in this field. Therefore, it is necessary to review the literature on experimental animal models that are used to screen agents with potential anti-gastric ulcer activity and describe their biochemical basis in order to facilitate their use in the development of new preventive and curative antiulcer drugs. There are many models used to induce ulcer such as pylorus ligation or it can be chemically induced by ethanol, NSAIDs (e.g. indomethacin) or many more. In this review paper, current in-vivo animal models of ulcers and the pathophysiological mechanisms underlying their induction, their drawbacks, as well as the challenges associated with their use have been discussed.

Keywords: animal models, peptic ulcer, ethanol, NSAIDs, indomethacin, pylorus ligation

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Author Biographies

Trilochan Satapathy, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Kalpana Sen, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Shailesh Sahu, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Bharti Pradhan, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Ayushi Gupta, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Md. Altaf Khan, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111, C.G., India

Dheeraj Kumar, University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

University College of Pharmacy Raipur, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, 492001, India

Abinash Satapathy, College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, C.G.

College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, C.G.

Neha Yadav, College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, C.G.

College of Veterinary Science and Animal Husbandry, Anjora- 491001, Durg, C.G.

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Satapathy T, Sen K, Sahu S, Pradhan B, Gupta A, Khan MA, Kumar D, Satapathy A, Yadav N. Experimental animal models for gastric ulcer / peptic ulcer: An overview. JDDT [Internet]. 15Jan.2024 [cited 25Feb.2024];14(1):182-9. Available from: https://jddtonline.info/index.php/jddt/article/view/6258

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